Recent Achievements in the Heterogeneity of Mammalian and Human Retinal Pigment Epithelium: In Search of a Stem Cell
Retinal pigment epithelium (RPE) cells are important fundamentally for the development and function of the retina. In this regard, the study of the morphological and molecular properties of RPE cells, as well as their regenerative capabilities, is of particular importance for biomedicine. However, t...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/3/281 |
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| author | Lyubov A. Rzhanova Yuliya V. Markitantova Maria A. Aleksandrova |
| author_facet | Lyubov A. Rzhanova Yuliya V. Markitantova Maria A. Aleksandrova |
| author_sort | Lyubov A. Rzhanova |
| collection | DOAJ |
| description | Retinal pigment epithelium (RPE) cells are important fundamentally for the development and function of the retina. In this regard, the study of the morphological and molecular properties of RPE cells, as well as their regenerative capabilities, is of particular importance for biomedicine. However, these studies are complicated by the fact that, despite the external morphological similarity of RPE cells, the RPE is a population of heterogeneous cells, the molecular genetic properties of which have begun to be revealed by sequencing methods only in recent years. This review carries out an analysis of the data from morphological and molecular genetic studies of the heterogeneity of RPE cells in mammals and humans, which reveals the individual differences in the subpopulations of RPE cells and the possible specificity of their functions. Particular attention is paid to discussing the properties of “stemness,” proliferation, and plasticity in the RPE, which may be useful for uncovering the mechanisms of retinal diseases associated with pathologies of the RPE and finding new ways of treating them. |
| first_indexed | 2024-03-08T04:00:00Z |
| format | Article |
| id | doaj.art-ca2ae3bf8d1f47afb66821467ad9d7fe |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-08T04:00:00Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-ca2ae3bf8d1f47afb66821467ad9d7fe2024-02-09T15:09:52ZengMDPI AGCells2073-44092024-02-0113328110.3390/cells13030281Recent Achievements in the Heterogeneity of Mammalian and Human Retinal Pigment Epithelium: In Search of a Stem CellLyubov A. Rzhanova0Yuliya V. Markitantova1Maria A. Aleksandrova2Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, 26 Vavilov Street, 119334 Moscow, RussiaKoltzov Institute of Developmental Biology of the Russian Academy of Sciences, 26 Vavilov Street, 119334 Moscow, RussiaKoltzov Institute of Developmental Biology of the Russian Academy of Sciences, 26 Vavilov Street, 119334 Moscow, RussiaRetinal pigment epithelium (RPE) cells are important fundamentally for the development and function of the retina. In this regard, the study of the morphological and molecular properties of RPE cells, as well as their regenerative capabilities, is of particular importance for biomedicine. However, these studies are complicated by the fact that, despite the external morphological similarity of RPE cells, the RPE is a population of heterogeneous cells, the molecular genetic properties of which have begun to be revealed by sequencing methods only in recent years. This review carries out an analysis of the data from morphological and molecular genetic studies of the heterogeneity of RPE cells in mammals and humans, which reveals the individual differences in the subpopulations of RPE cells and the possible specificity of their functions. Particular attention is paid to discussing the properties of “stemness,” proliferation, and plasticity in the RPE, which may be useful for uncovering the mechanisms of retinal diseases associated with pathologies of the RPE and finding new ways of treating them.https://www.mdpi.com/2073-4409/13/3/281retinal pigment epitheliumRPEmorphometry mapheterogeneitycell subpopulationRPE stem cells (RPESCs) |
| spellingShingle | Lyubov A. Rzhanova Yuliya V. Markitantova Maria A. Aleksandrova Recent Achievements in the Heterogeneity of Mammalian and Human Retinal Pigment Epithelium: In Search of a Stem Cell Cells retinal pigment epithelium RPE morphometry map heterogeneity cell subpopulation RPE stem cells (RPESCs) |
| title | Recent Achievements in the Heterogeneity of Mammalian and Human Retinal Pigment Epithelium: In Search of a Stem Cell |
| title_full | Recent Achievements in the Heterogeneity of Mammalian and Human Retinal Pigment Epithelium: In Search of a Stem Cell |
| title_fullStr | Recent Achievements in the Heterogeneity of Mammalian and Human Retinal Pigment Epithelium: In Search of a Stem Cell |
| title_full_unstemmed | Recent Achievements in the Heterogeneity of Mammalian and Human Retinal Pigment Epithelium: In Search of a Stem Cell |
| title_short | Recent Achievements in the Heterogeneity of Mammalian and Human Retinal Pigment Epithelium: In Search of a Stem Cell |
| title_sort | recent achievements in the heterogeneity of mammalian and human retinal pigment epithelium in search of a stem cell |
| topic | retinal pigment epithelium RPE morphometry map heterogeneity cell subpopulation RPE stem cells (RPESCs) |
| url | https://www.mdpi.com/2073-4409/13/3/281 |
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