Networks of fibers and factors: regulation of capsule formation in Cryptococcus neoformans [version 1; referees: 5 approved]
The ability of the pathogenic fungus Cryptococcus neoformans to cause life-threatening meningoencephalitis in immunocompromised individuals is due in large part to elaboration of a capsule consisting of polysaccharide fibers. The size of the cell-associated capsule is remarkably responsive to a vari...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2016-07-01
|
| Series: | F1000Research |
| Subjects: | |
| Online Access: | http://f1000research.com/articles/5-1786/v1 |
| _version_ | 1828190629955371008 |
|---|---|
| author | Hao Ding François L. Mayer Eddy Sánchez-León Glauber R. de S. Araújo Susana Frases James W. Kronstad |
| author_facet | Hao Ding François L. Mayer Eddy Sánchez-León Glauber R. de S. Araújo Susana Frases James W. Kronstad |
| author_sort | Hao Ding |
| collection | DOAJ |
| description | The ability of the pathogenic fungus Cryptococcus neoformans to cause life-threatening meningoencephalitis in immunocompromised individuals is due in large part to elaboration of a capsule consisting of polysaccharide fibers. The size of the cell-associated capsule is remarkably responsive to a variety of environmental and host conditions, but the mechanistic details of the regulation, synthesis, trafficking, and attachment of the polysaccharides are poorly understood. Recent studies reveal a complex network of transcription factors that influence capsule elaboration in response to several different signals of relevance to disease (e.g., iron deprivation). The emerging complexity of the network is consistent with the diversity of conditions that influence the capsule and illustrates the responsiveness of the fungus to both the environment and mammalian hosts. |
| first_indexed | 2024-04-12T08:25:46Z |
| format | Article |
| id | doaj.art-ca2bad1959e245b7819ba05d754438da |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-12T08:25:46Z |
| publishDate | 2016-07-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-ca2bad1959e245b7819ba05d754438da2022-12-22T03:40:25ZengF1000 Research LtdF1000Research2046-14022016-07-01510.12688/f1000research.8854.19529Networks of fibers and factors: regulation of capsule formation in Cryptococcus neoformans [version 1; referees: 5 approved]Hao Ding0François L. Mayer1Eddy Sánchez-León2Glauber R. de S. Araújo3Susana Frases4James W. Kronstad5Michael Smith Laboratories, University of British Columbia, Vancouver, CanadaMichael Smith Laboratories, University of British Columbia, Vancouver, CanadaMichael Smith Laboratories, University of British Columbia, Vancouver, CanadaLaboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, CanadaThe ability of the pathogenic fungus Cryptococcus neoformans to cause life-threatening meningoencephalitis in immunocompromised individuals is due in large part to elaboration of a capsule consisting of polysaccharide fibers. The size of the cell-associated capsule is remarkably responsive to a variety of environmental and host conditions, but the mechanistic details of the regulation, synthesis, trafficking, and attachment of the polysaccharides are poorly understood. Recent studies reveal a complex network of transcription factors that influence capsule elaboration in response to several different signals of relevance to disease (e.g., iron deprivation). The emerging complexity of the network is consistent with the diversity of conditions that influence the capsule and illustrates the responsiveness of the fungus to both the environment and mammalian hosts.http://f1000research.com/articles/5-1786/v1Antimicrobials & Drug ResistanceCellular Microbiology & PathogenesisEpidemiologyFungal InfectionsInfectious Diseases of the Nervous SystemMedical MicrobiologyMicrobial Evolution & GenomicsMicrobial Physiology & Metabolism |
| spellingShingle | Hao Ding François L. Mayer Eddy Sánchez-León Glauber R. de S. Araújo Susana Frases James W. Kronstad Networks of fibers and factors: regulation of capsule formation in Cryptococcus neoformans [version 1; referees: 5 approved] F1000Research Antimicrobials & Drug Resistance Cellular Microbiology & Pathogenesis Epidemiology Fungal Infections Infectious Diseases of the Nervous System Medical Microbiology Microbial Evolution & Genomics Microbial Physiology & Metabolism |
| title | Networks of fibers and factors: regulation of capsule formation in Cryptococcus neoformans [version 1; referees: 5 approved] |
| title_full | Networks of fibers and factors: regulation of capsule formation in Cryptococcus neoformans [version 1; referees: 5 approved] |
| title_fullStr | Networks of fibers and factors: regulation of capsule formation in Cryptococcus neoformans [version 1; referees: 5 approved] |
| title_full_unstemmed | Networks of fibers and factors: regulation of capsule formation in Cryptococcus neoformans [version 1; referees: 5 approved] |
| title_short | Networks of fibers and factors: regulation of capsule formation in Cryptococcus neoformans [version 1; referees: 5 approved] |
| title_sort | networks of fibers and factors regulation of capsule formation in cryptococcus neoformans version 1 referees 5 approved |
| topic | Antimicrobials & Drug Resistance Cellular Microbiology & Pathogenesis Epidemiology Fungal Infections Infectious Diseases of the Nervous System Medical Microbiology Microbial Evolution & Genomics Microbial Physiology & Metabolism |
| url | http://f1000research.com/articles/5-1786/v1 |
| work_keys_str_mv | AT haoding networksoffibersandfactorsregulationofcapsuleformationincryptococcusneoformansversion1referees5approved AT francoislmayer networksoffibersandfactorsregulationofcapsuleformationincryptococcusneoformansversion1referees5approved AT eddysanchezleon networksoffibersandfactorsregulationofcapsuleformationincryptococcusneoformansversion1referees5approved AT glauberrdesaraujo networksoffibersandfactorsregulationofcapsuleformationincryptococcusneoformansversion1referees5approved AT susanafrases networksoffibersandfactorsregulationofcapsuleformationincryptococcusneoformansversion1referees5approved AT jameswkronstad networksoffibersandfactorsregulationofcapsuleformationincryptococcusneoformansversion1referees5approved |