Dual mechanism of DICER downregulation facilitates cancer metastasis

Dual mechanism of DICER downregulation facilitates cancer metastasis

Although downregulation of DICER – a critical enzyme in microRNA (miRNA) maturation – reportedly promotes cancer metastasis, understanding of its upstream regulators remains limited. Our recent study demonstrated a noncanonical oncogenic effect of hypoxia-inducible factor-1α (HIF-1α), which directly...

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Bibliographic Details
Main Authors: Hui-Huang Lai, Pai-Sheng Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2018-09-01
Series:Molecular & Cellular Oncology
Subjects:
dicer
hif-1α
mirna
metastasis
Online Access:http://dx.doi.org/10.1080/23723556.2018.1472056

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