Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management
Sepsis has evolved as an enormous health issue amongst critically ill patients. It is a major risk factor that results in multiple organ failure and shock. Acute kidney injury (AKI) is one of the most frequent complications underlying sepsis, which portends a heavy burden of mortality and morbidity....
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223009745 |
| _version_ | 1797744091433271296 |
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| author | Acharya Balkrishna Sugandh Sinha Ashwani Kumar Vedpriya Arya Ajay Kumar Gautam Martin Valis Kamil Kuca Dinesh Kumar Ryszard Amarowicz |
| author_facet | Acharya Balkrishna Sugandh Sinha Ashwani Kumar Vedpriya Arya Ajay Kumar Gautam Martin Valis Kamil Kuca Dinesh Kumar Ryszard Amarowicz |
| author_sort | Acharya Balkrishna |
| collection | DOAJ |
| description | Sepsis has evolved as an enormous health issue amongst critically ill patients. It is a major risk factor that results in multiple organ failure and shock. Acute kidney injury (AKI) is one of the most frequent complications underlying sepsis, which portends a heavy burden of mortality and morbidity. Thus, the present review is aimed to provide an insight into the recent progression in the molecular mechanisms targeting dysregulated immune response and cellular dysfunction involved in the development of sepsis-associated AKI, accentuating the phytoconstituents as eligible candidates for attenuating the onset and progression of sepsis-associated AKI. The pathogenesis of sepsis-mediated AKI entails a complicated mechanism and is likely to involve a distinct constellation of hemodynamic, inflammatory, and immune mechanisms. Novel biomarkers like neutrophil gelatinase-associated lipocalin, soluble triggering receptor expressed on myeloid cells 1, procalcitonin, alpha-1-microglobulin, and presepsin can help in a more sensitive diagnosis of sepsis-associated AKI. Many bioactive compounds like curcumin, resveratrol, baicalin, quercetin, and polydatin are reported to play an important role in the prevention and management of sepsis-associated AKI by decreasing serum creatinine, blood urea nitrogen, cystatin C, lipid peroxidation, oxidative stress, IL-1β, TNF-α, NF-κB, and increasing the activity of antioxidant enzymes and level of PPARγ. The plant bioactive compounds could be developed into a drug-developing candidate in managing sepsis-mediated acute kidney injury after detailed follow-up studies. Lastly, the gut-kidney axis may be a more promising therapeutic target against the onset of septic AKI, but a deeper understanding of the molecular pathways is still required. |
| first_indexed | 2024-03-12T15:04:45Z |
| format | Article |
| id | doaj.art-ca2e603e349a4618809f36e782a00111 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T15:04:45Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-ca2e603e349a4618809f36e782a001112023-08-13T04:52:55ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-09-01165115183Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its managementAcharya Balkrishna0Sugandh Sinha1Ashwani Kumar2Vedpriya Arya3Ajay Kumar Gautam4Martin Valis5Kamil Kuca6Dinesh Kumar7Ryszard Amarowicz8Patanjali Herbal Research Department, Patanjali Research Institute, Haridwar, IndiaPatanjali Herbal Research Department, Patanjali Research Institute, Haridwar, IndiaPatanjali Herbal Research Department, Patanjali Research Institute, Haridwar, India; Corresponding author.Patanjali Herbal Research Department, Patanjali Research Institute, Haridwar, IndiaPatanjali Herbal Research Department, Patanjali Research Institute, Haridwar, IndiaDepartment of Neurology, Charles University in Prague, Faculty of Medicine in Hradec Králové and University Hospital, Hradec Králové, Czech RepublicDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital in Hradec Kralove, Sokolska 581, Hradec Kralove, Czech Republic; Corresponding author at: Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.School of Bioengineering and Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan, IndiaInstitute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, PolandSepsis has evolved as an enormous health issue amongst critically ill patients. It is a major risk factor that results in multiple organ failure and shock. Acute kidney injury (AKI) is one of the most frequent complications underlying sepsis, which portends a heavy burden of mortality and morbidity. Thus, the present review is aimed to provide an insight into the recent progression in the molecular mechanisms targeting dysregulated immune response and cellular dysfunction involved in the development of sepsis-associated AKI, accentuating the phytoconstituents as eligible candidates for attenuating the onset and progression of sepsis-associated AKI. The pathogenesis of sepsis-mediated AKI entails a complicated mechanism and is likely to involve a distinct constellation of hemodynamic, inflammatory, and immune mechanisms. Novel biomarkers like neutrophil gelatinase-associated lipocalin, soluble triggering receptor expressed on myeloid cells 1, procalcitonin, alpha-1-microglobulin, and presepsin can help in a more sensitive diagnosis of sepsis-associated AKI. Many bioactive compounds like curcumin, resveratrol, baicalin, quercetin, and polydatin are reported to play an important role in the prevention and management of sepsis-associated AKI by decreasing serum creatinine, blood urea nitrogen, cystatin C, lipid peroxidation, oxidative stress, IL-1β, TNF-α, NF-κB, and increasing the activity of antioxidant enzymes and level of PPARγ. The plant bioactive compounds could be developed into a drug-developing candidate in managing sepsis-mediated acute kidney injury after detailed follow-up studies. Lastly, the gut-kidney axis may be a more promising therapeutic target against the onset of septic AKI, but a deeper understanding of the molecular pathways is still required.http://www.sciencedirect.com/science/article/pii/S0753332223009745SepsisAcute kidney injuryPyroptosisBiomarkersPlant bioactive compoundsGut-kidney axis |
| spellingShingle | Acharya Balkrishna Sugandh Sinha Ashwani Kumar Vedpriya Arya Ajay Kumar Gautam Martin Valis Kamil Kuca Dinesh Kumar Ryszard Amarowicz Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management Biomedicine & Pharmacotherapy Sepsis Acute kidney injury Pyroptosis Biomarkers Plant bioactive compounds Gut-kidney axis |
| title | Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management |
| title_full | Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management |
| title_fullStr | Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management |
| title_full_unstemmed | Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management |
| title_short | Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management |
| title_sort | sepsis mediated renal dysfunction pathophysiology biomarkers and role of phytoconstituents in its management |
| topic | Sepsis Acute kidney injury Pyroptosis Biomarkers Plant bioactive compounds Gut-kidney axis |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223009745 |
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