Clinical activity is an independent risk factor of ischemic heart and cerebrovascular arterial disease in patients with inflammatory bowel disease.
BACKGROUND AND AIMS:In inflammatory bowel disease (IBD), the impact of established cardiovascular risk factors and disease-related factors on the risk of acute arterial events is still unclear. We aimed to identify risk factors of acute arterial events in patients with IBD. METHODS:All consecutive p...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6118365?pdf=render |
| _version_ | 1818196900876124160 |
|---|---|
| author | Guillaume Le Gall Julien Kirchgesner Mohamed Bejaoui Cécilia Landman Isabelle Nion-Larmurier Anne Bourrier Harry Sokol Philippe Seksik Laurent Beaugerie |
| author_facet | Guillaume Le Gall Julien Kirchgesner Mohamed Bejaoui Cécilia Landman Isabelle Nion-Larmurier Anne Bourrier Harry Sokol Philippe Seksik Laurent Beaugerie |
| author_sort | Guillaume Le Gall |
| collection | DOAJ |
| description | BACKGROUND AND AIMS:In inflammatory bowel disease (IBD), the impact of established cardiovascular risk factors and disease-related factors on the risk of acute arterial events is still unclear. We aimed to identify risk factors of acute arterial events in patients with IBD. METHODS:All consecutive patients followed at Saint-Antoine Hospital between 1996 and 2015 with subsequent occurrence of acute arterial events (acute coronary syndrome or ischemic stroke) were identified. Traditional cardiovascular risk factors, treatment exposure, systemic inflammation (mean serum CRP level greater than or equal to 5 mg/L) and IBD clinical activity were assessed. A nested case-control study was performed including cases and controls without arterial ischemic event, matched on age, gender, and disease extent. RESULTS:A total of 30 patients (median age at acute vascular event occurrence: 42 years (interquartile range: 25-59)) developed acute coronary syndrome (n = 22) or ischemic stroke (n = 8). In univariate analysis, clinical disease activity and the persistence of systemic inflammation, diabetes, dyslipidemia and hypertension were significantly associated with an increased risk of acute arterial events. Neither protective nor aggravating effects associated with treatment exposure were identified. In multivariate analysis, the presence of diabetes (Odds ratio (OR): 14.5, 95% confidence interval (CI): 1.1-184.7) and clinical disease activity (OR: 10.4, 95% CI: 2.1-49.9) remained significantly associated with the risk of acute arterial event. CONCLUSION:Disease activity may have an independent impact on the risk of acute arterial events in patients with IBD. These findings may highlight new potential benefits of optimizing anti-inflammatory treatment in patients with persisting clinical activity. |
| first_indexed | 2024-12-12T01:41:26Z |
| format | Article |
| id | doaj.art-ca30c334bd36411a8bc12c4f921d22ce |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T01:41:26Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ca30c334bd36411a8bc12c4f921d22ce2022-12-22T00:42:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01138e020199110.1371/journal.pone.0201991Clinical activity is an independent risk factor of ischemic heart and cerebrovascular arterial disease in patients with inflammatory bowel disease.Guillaume Le GallJulien KirchgesnerMohamed BejaouiCécilia LandmanIsabelle Nion-LarmurierAnne BourrierHarry SokolPhilippe SeksikLaurent BeaugerieBACKGROUND AND AIMS:In inflammatory bowel disease (IBD), the impact of established cardiovascular risk factors and disease-related factors on the risk of acute arterial events is still unclear. We aimed to identify risk factors of acute arterial events in patients with IBD. METHODS:All consecutive patients followed at Saint-Antoine Hospital between 1996 and 2015 with subsequent occurrence of acute arterial events (acute coronary syndrome or ischemic stroke) were identified. Traditional cardiovascular risk factors, treatment exposure, systemic inflammation (mean serum CRP level greater than or equal to 5 mg/L) and IBD clinical activity were assessed. A nested case-control study was performed including cases and controls without arterial ischemic event, matched on age, gender, and disease extent. RESULTS:A total of 30 patients (median age at acute vascular event occurrence: 42 years (interquartile range: 25-59)) developed acute coronary syndrome (n = 22) or ischemic stroke (n = 8). In univariate analysis, clinical disease activity and the persistence of systemic inflammation, diabetes, dyslipidemia and hypertension were significantly associated with an increased risk of acute arterial events. Neither protective nor aggravating effects associated with treatment exposure were identified. In multivariate analysis, the presence of diabetes (Odds ratio (OR): 14.5, 95% confidence interval (CI): 1.1-184.7) and clinical disease activity (OR: 10.4, 95% CI: 2.1-49.9) remained significantly associated with the risk of acute arterial event. CONCLUSION:Disease activity may have an independent impact on the risk of acute arterial events in patients with IBD. These findings may highlight new potential benefits of optimizing anti-inflammatory treatment in patients with persisting clinical activity.http://europepmc.org/articles/PMC6118365?pdf=render |
| spellingShingle | Guillaume Le Gall Julien Kirchgesner Mohamed Bejaoui Cécilia Landman Isabelle Nion-Larmurier Anne Bourrier Harry Sokol Philippe Seksik Laurent Beaugerie Clinical activity is an independent risk factor of ischemic heart and cerebrovascular arterial disease in patients with inflammatory bowel disease. PLoS ONE |
| title | Clinical activity is an independent risk factor of ischemic heart and cerebrovascular arterial disease in patients with inflammatory bowel disease. |
| title_full | Clinical activity is an independent risk factor of ischemic heart and cerebrovascular arterial disease in patients with inflammatory bowel disease. |
| title_fullStr | Clinical activity is an independent risk factor of ischemic heart and cerebrovascular arterial disease in patients with inflammatory bowel disease. |
| title_full_unstemmed | Clinical activity is an independent risk factor of ischemic heart and cerebrovascular arterial disease in patients with inflammatory bowel disease. |
| title_short | Clinical activity is an independent risk factor of ischemic heart and cerebrovascular arterial disease in patients with inflammatory bowel disease. |
| title_sort | clinical activity is an independent risk factor of ischemic heart and cerebrovascular arterial disease in patients with inflammatory bowel disease |
| url | http://europepmc.org/articles/PMC6118365?pdf=render |
| work_keys_str_mv | AT guillaumelegall clinicalactivityisanindependentriskfactorofischemicheartandcerebrovasculararterialdiseaseinpatientswithinflammatoryboweldisease AT julienkirchgesner clinicalactivityisanindependentriskfactorofischemicheartandcerebrovasculararterialdiseaseinpatientswithinflammatoryboweldisease AT mohamedbejaoui clinicalactivityisanindependentriskfactorofischemicheartandcerebrovasculararterialdiseaseinpatientswithinflammatoryboweldisease AT cecilialandman clinicalactivityisanindependentriskfactorofischemicheartandcerebrovasculararterialdiseaseinpatientswithinflammatoryboweldisease AT isabellenionlarmurier clinicalactivityisanindependentriskfactorofischemicheartandcerebrovasculararterialdiseaseinpatientswithinflammatoryboweldisease AT annebourrier clinicalactivityisanindependentriskfactorofischemicheartandcerebrovasculararterialdiseaseinpatientswithinflammatoryboweldisease AT harrysokol clinicalactivityisanindependentriskfactorofischemicheartandcerebrovasculararterialdiseaseinpatientswithinflammatoryboweldisease AT philippeseksik clinicalactivityisanindependentriskfactorofischemicheartandcerebrovasculararterialdiseaseinpatientswithinflammatoryboweldisease AT laurentbeaugerie clinicalactivityisanindependentriskfactorofischemicheartandcerebrovasculararterialdiseaseinpatientswithinflammatoryboweldisease |