Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5.

Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5.

Host resistance to Toxoplasma gondii relies on CD8 T cell IFNγ responses, which if modulated by the host or parasite could influence chronic infection and parasite transmission between hosts. Since host-parasite interactions that govern this response are not fully elucidated, we investigated require...

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Bibliographic Details
Main Authors: Angel K Kongsomboonvech, Felipe Rodriguez, Anh L Diep, Brandon M Justice, Brayan E Castallanos, Ana Camejo, Debanjan Mukhopadhyay, Gregory A Taylor, Masahiro Yamamoto, Jeroen P J Saeij, Michael L Reese, Kirk D C Jensen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008327

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