Potential Roles of Melatonin in Doxorubicin-Induced Cardiotoxicity: From Cellular Mechanisms to Clinical Application

Potential Roles of Melatonin in Doxorubicin-Induced Cardiotoxicity: From Cellular Mechanisms to Clinical Application

Doxorubicin is a potent chemotherapeutic drug; however, its clinical application has been limited due to its cardiotoxicity. One of the major mechanisms of doxorubicin-induced cardiotoxicity is the induction of oxidative stress. Evidence from in vitro and in vivo studies demonstrates that melatonin...

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Bibliographic Details
Main Authors: Tanawat Attachaipanich, Siriporn C. Chattipakorn, Nipon Chattipakorn
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
melatonin
doxorubicin
anthracycline
cardiotoxicity
mitochondria
Online Access:https://www.mdpi.com/1999-4923/15/3/785

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