Newborn colonization and antibiotic susceptibility patterns of Streptococcus agalactiae at the University of Gondar Referral Hospital, Northwest Ethiopia
Abstract Background Group B Streptococcus (GBS) that asymptomatically colonizing the recto-vaginal area of women is the most important cause of neonatal colonization. There is paucity of evidence about newborn colonization with GBS in Ethiopia. Thus, this study was aimed to determine the prevalence...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-11-01
|
| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12887-018-1350-1 |
| _version_ | 1818889021672128512 |
|---|---|
| author | Mucheye Gizachew Moges Tiruneh Feleke Moges Mulat Adefris Zemene Tigabu Belay Tessema |
| author_facet | Mucheye Gizachew Moges Tiruneh Feleke Moges Mulat Adefris Zemene Tigabu Belay Tessema |
| author_sort | Mucheye Gizachew |
| collection | DOAJ |
| description | Abstract Background Group B Streptococcus (GBS) that asymptomatically colonizing the recto-vaginal area of women is the most important cause of neonatal colonization. There is paucity of evidence about newborn colonization with GBS in Ethiopia. Thus, this study was aimed to determine the prevalence of newborn colonization with GBS, antibiotic susceptibility patterns of the isolates and associated risk factors at the University of Gondar Referral Hospital in Northwest Ethiopia Methods A prospective cross sectional study was conducted from December 2016 to November 2017. A total of 1,155 swabs from nasal, ear and umbilical areas of the newborns were collected from the 385 newborns. Identifications of the isolates and antibiotic susceptibility testing were done by using conventional methods. Results Sixty two (16.1%, 95% CI: 12.2% - 20%) of the newborns were colonized by GBS. Seven percent of the total specimens were positive for GBS. The antibiotics susceptibility rates of GBS (average of the three body sites tested) were 95.1%, 89.6%, 88.9%, 85.7%, 85.3%, 81.3%, 76.9%, 76.1%, 73.8%, and 34.4% to ampicillin, penicillin, ciprofloxacin, chloramphenicol, vancomycin, azitromycin, erythromycin, clindamycin, ceftriaxone, and tetracycline, respectively. A multilogistic regression analyses were shown that the newborns that were from mothers whose education status was below tertiary level, and newborns from mothers who were: being employed, being nullipara and multigravida were at risk for colonization with GBS. Conclusion Prevalence of neonatal colonization with GBS was higher than it was reported in three decades ago in Ethiopia. Ciprofloxacin, chloramphenicol, vancomycin and azithromycin were identified as the drug of choice next to ampicillin and penicillin. |
| first_indexed | 2024-12-19T17:02:24Z |
| format | Article |
| id | doaj.art-ca33b7fdae4d425382592796b27ceb53 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-19T17:02:24Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-ca33b7fdae4d425382592796b27ceb532022-12-21T20:13:17ZengBMCBMC Pediatrics1471-24312018-11-0118111110.1186/s12887-018-1350-1Newborn colonization and antibiotic susceptibility patterns of Streptococcus agalactiae at the University of Gondar Referral Hospital, Northwest EthiopiaMucheye Gizachew0Moges Tiruneh1Feleke Moges2Mulat Adefris3Zemene Tigabu4Belay Tessema5Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of GondarDepartment of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of GondarDepartment of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of GondarDepartment of Gynecology and Obstetrics, School of Medicine, College of Medicine and Health Sciences, University of GondarDepartment of Pediatrics, School of Medicine, College of Medicine and Health Sciences, University of GondarDepartment of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of GondarAbstract Background Group B Streptococcus (GBS) that asymptomatically colonizing the recto-vaginal area of women is the most important cause of neonatal colonization. There is paucity of evidence about newborn colonization with GBS in Ethiopia. Thus, this study was aimed to determine the prevalence of newborn colonization with GBS, antibiotic susceptibility patterns of the isolates and associated risk factors at the University of Gondar Referral Hospital in Northwest Ethiopia Methods A prospective cross sectional study was conducted from December 2016 to November 2017. A total of 1,155 swabs from nasal, ear and umbilical areas of the newborns were collected from the 385 newborns. Identifications of the isolates and antibiotic susceptibility testing were done by using conventional methods. Results Sixty two (16.1%, 95% CI: 12.2% - 20%) of the newborns were colonized by GBS. Seven percent of the total specimens were positive for GBS. The antibiotics susceptibility rates of GBS (average of the three body sites tested) were 95.1%, 89.6%, 88.9%, 85.7%, 85.3%, 81.3%, 76.9%, 76.1%, 73.8%, and 34.4% to ampicillin, penicillin, ciprofloxacin, chloramphenicol, vancomycin, azitromycin, erythromycin, clindamycin, ceftriaxone, and tetracycline, respectively. A multilogistic regression analyses were shown that the newborns that were from mothers whose education status was below tertiary level, and newborns from mothers who were: being employed, being nullipara and multigravida were at risk for colonization with GBS. Conclusion Prevalence of neonatal colonization with GBS was higher than it was reported in three decades ago in Ethiopia. Ciprofloxacin, chloramphenicol, vancomycin and azithromycin were identified as the drug of choice next to ampicillin and penicillin.http://link.springer.com/article/10.1186/s12887-018-1350-1Antibiotic susceptibility patternColonizationGroup B StreptococcusNewborns |
| spellingShingle | Mucheye Gizachew Moges Tiruneh Feleke Moges Mulat Adefris Zemene Tigabu Belay Tessema Newborn colonization and antibiotic susceptibility patterns of Streptococcus agalactiae at the University of Gondar Referral Hospital, Northwest Ethiopia BMC Pediatrics Antibiotic susceptibility pattern Colonization Group B Streptococcus Newborns |
| title | Newborn colonization and antibiotic susceptibility patterns of Streptococcus agalactiae at the University of Gondar Referral Hospital, Northwest Ethiopia |
| title_full | Newborn colonization and antibiotic susceptibility patterns of Streptococcus agalactiae at the University of Gondar Referral Hospital, Northwest Ethiopia |
| title_fullStr | Newborn colonization and antibiotic susceptibility patterns of Streptococcus agalactiae at the University of Gondar Referral Hospital, Northwest Ethiopia |
| title_full_unstemmed | Newborn colonization and antibiotic susceptibility patterns of Streptococcus agalactiae at the University of Gondar Referral Hospital, Northwest Ethiopia |
| title_short | Newborn colonization and antibiotic susceptibility patterns of Streptococcus agalactiae at the University of Gondar Referral Hospital, Northwest Ethiopia |
| title_sort | newborn colonization and antibiotic susceptibility patterns of streptococcus agalactiae at the university of gondar referral hospital northwest ethiopia |
| topic | Antibiotic susceptibility pattern Colonization Group B Streptococcus Newborns |
| url | http://link.springer.com/article/10.1186/s12887-018-1350-1 |
| work_keys_str_mv | AT mucheyegizachew newborncolonizationandantibioticsusceptibilitypatternsofstreptococcusagalactiaeattheuniversityofgondarreferralhospitalnorthwestethiopia AT mogestiruneh newborncolonizationandantibioticsusceptibilitypatternsofstreptococcusagalactiaeattheuniversityofgondarreferralhospitalnorthwestethiopia AT felekemoges newborncolonizationandantibioticsusceptibilitypatternsofstreptococcusagalactiaeattheuniversityofgondarreferralhospitalnorthwestethiopia AT mulatadefris newborncolonizationandantibioticsusceptibilitypatternsofstreptococcusagalactiaeattheuniversityofgondarreferralhospitalnorthwestethiopia AT zemenetigabu newborncolonizationandantibioticsusceptibilitypatternsofstreptococcusagalactiaeattheuniversityofgondarreferralhospitalnorthwestethiopia AT belaytessema newborncolonizationandantibioticsusceptibilitypatternsofstreptococcusagalactiaeattheuniversityofgondarreferralhospitalnorthwestethiopia |