Maternal Ureaplasma/Mycoplasma colonization during pregnancy and neurodevelopmental outcomes for preterm infants
IntroductionUreaplasma (U.) and Mycoplasma (M.) species have been related to pregnancy complications (including preterm birth) and worse neonatal outcomes. The aim of our work is to evaluate neurodevelopmental outcomes in preterm infants born to mothers with Ureaplasma/Mycoplasma colonization during...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.893812/full |
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| author | Francesca Gallini Francesca Gallini Domenico Umberto De Rose Domenico Umberto De Rose Maria Coppola Maria Sofia Pelosi Francesco Cota Francesco Cota Anthea Bottoni Daniela Ricci Daniela Ricci Domenico Marco Romeo Domenico Marco Romeo Teresa Spanu Teresa Spanu Luca Maggio Luca Maggio Eugenio Mercuri Eugenio Mercuri Giovanni Vento Giovanni Vento |
| author_facet | Francesca Gallini Francesca Gallini Domenico Umberto De Rose Domenico Umberto De Rose Maria Coppola Maria Sofia Pelosi Francesco Cota Francesco Cota Anthea Bottoni Daniela Ricci Daniela Ricci Domenico Marco Romeo Domenico Marco Romeo Teresa Spanu Teresa Spanu Luca Maggio Luca Maggio Eugenio Mercuri Eugenio Mercuri Giovanni Vento Giovanni Vento |
| author_sort | Francesca Gallini |
| collection | DOAJ |
| description | IntroductionUreaplasma (U.) and Mycoplasma (M.) species have been related to pregnancy complications (including preterm birth) and worse neonatal outcomes. The aim of our work is to evaluate neurodevelopmental outcomes in preterm infants born to mothers with Ureaplasma/Mycoplasma colonization during pregnancy.MethodsPreterm infants with gestational age (GA) of ≤ 30 weeks were included in a retrospective follow-up study. To evaluate the effects of maternal vaginal colonization, we divided preterm infants into two groups: exposed and unexposed infants. All infants were assessed at 24 ± 3 months of age using Griffith’s Mental Developmental Scales (GMDS).ResultsAmong 254 preterm infants, only 32 infants (12.6%) were exposed to U. /M. colonization during pregnancy. Exposed infants and unexposed ones had a similar Griffith′s Developmental Quotient (106 ± 27.2 vs. 108.9 ± 19.5, respectively), without significant differences (p = 0.46). However, exposed infants had a significantly poorer outcome than their unexposed peers in terms of locomotor abilities (100.7 ± 28.3 exposed vs. 111.5 ± 26.1 unexposed, p = 0.03).ConclusionFor visual and hearing impairment, exposed and unexposed infants had similar incidences of cognitive and motor impairment. However, exposed infants had significantly lower locomotor scores than unexposed peers. |
| first_indexed | 2024-12-10T19:49:45Z |
| format | Article |
| id | doaj.art-ca34aaeb5602496dabd11dc77b8e2eb4 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-10T19:49:45Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-ca34aaeb5602496dabd11dc77b8e2eb42022-12-22T01:35:48ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-08-011010.3389/fped.2022.893812893812Maternal Ureaplasma/Mycoplasma colonization during pregnancy and neurodevelopmental outcomes for preterm infantsFrancesca Gallini0Francesca Gallini1Domenico Umberto De Rose2Domenico Umberto De Rose3Maria Coppola4Maria Sofia Pelosi5Francesco Cota6Francesco Cota7Anthea Bottoni8Daniela Ricci9Daniela Ricci10Domenico Marco Romeo11Domenico Marco Romeo12Teresa Spanu13Teresa Spanu14Luca Maggio15Luca Maggio16Eugenio Mercuri17Eugenio Mercuri18Giovanni Vento19Giovanni Vento20Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario “Agostino Gemelli” Istituto di Ricovero e Cura a Carattere Scientifico, Rome, ItalyUniversità Cattolica del Sacro Cuore, Milan, ItalyNeonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario “Agostino Gemelli” Istituto di Ricovero e Cura a Carattere Scientifico, Rome, ItalyNeonatal Intensive Care Unit, Medical and Surgical Department of Fetus—Newborn—Infant, “Bambino Gesù” Children’s Hospital Istituto di Ricovero e Cura a Carattere Scientifico, Rome, ItalyNeonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario “Agostino Gemelli” Istituto di Ricovero e Cura a Carattere Scientifico, Rome, ItalyNeonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario “Agostino Gemelli” Istituto di Ricovero e Cura a Carattere Scientifico, Rome, ItalyNeonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario “Agostino Gemelli” Istituto di Ricovero e Cura a Carattere Scientifico, Rome, ItalyUniversità Cattolica del Sacro Cuore, Milan, ItalyNeonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario “Agostino Gemelli” Istituto di Ricovero e Cura a Carattere Scientifico, Rome, ItalyNational Centre of Services and Research for the Prevention of Blindness and Rehabilitation of Low Vision Patients–International Agency for the Prevention of Blindness (IAPB) Italia Onlus, Rome, ItalyPediatric Neurology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario “Agostino Gemelli” Istituto di Ricovero e Cura a Carattere Scientifico, Rome, ItalyUniversità Cattolica del Sacro Cuore, Milan, ItalyPediatric Neurology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario “Agostino Gemelli” Istituto di Ricovero e Cura a Carattere Scientifico, Rome, ItalyUniversità Cattolica del Sacro Cuore, Milan, ItalyDepartment of Laboratory and Infectious Sciences, Fondazione Policlinico Universitario “Agostino Gemelli” Istituto di Ricovero e Cura a Carattere Scientifico, Rome, ItalyUniversità Cattolica del Sacro Cuore, Milan, ItalyNeonatology Unit, S. Camillo—Forlanini Hospital, Rome, ItalyUniversità Cattolica del Sacro Cuore, Milan, ItalyPediatric Neurology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario “Agostino Gemelli” Istituto di Ricovero e Cura a Carattere Scientifico, Rome, ItalyNeonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario “Agostino Gemelli” Istituto di Ricovero e Cura a Carattere Scientifico, Rome, ItalyUniversità Cattolica del Sacro Cuore, Milan, ItalyIntroductionUreaplasma (U.) and Mycoplasma (M.) species have been related to pregnancy complications (including preterm birth) and worse neonatal outcomes. The aim of our work is to evaluate neurodevelopmental outcomes in preterm infants born to mothers with Ureaplasma/Mycoplasma colonization during pregnancy.MethodsPreterm infants with gestational age (GA) of ≤ 30 weeks were included in a retrospective follow-up study. To evaluate the effects of maternal vaginal colonization, we divided preterm infants into two groups: exposed and unexposed infants. All infants were assessed at 24 ± 3 months of age using Griffith’s Mental Developmental Scales (GMDS).ResultsAmong 254 preterm infants, only 32 infants (12.6%) were exposed to U. /M. colonization during pregnancy. Exposed infants and unexposed ones had a similar Griffith′s Developmental Quotient (106 ± 27.2 vs. 108.9 ± 19.5, respectively), without significant differences (p = 0.46). However, exposed infants had a significantly poorer outcome than their unexposed peers in terms of locomotor abilities (100.7 ± 28.3 exposed vs. 111.5 ± 26.1 unexposed, p = 0.03).ConclusionFor visual and hearing impairment, exposed and unexposed infants had similar incidences of cognitive and motor impairment. However, exposed infants had significantly lower locomotor scores than unexposed peers.https://www.frontiersin.org/articles/10.3389/fped.2022.893812/fullneonatenewbornneurodevelopmentcognitivepregnantprematurity—risk assessment and prevention |
| spellingShingle | Francesca Gallini Francesca Gallini Domenico Umberto De Rose Domenico Umberto De Rose Maria Coppola Maria Sofia Pelosi Francesco Cota Francesco Cota Anthea Bottoni Daniela Ricci Daniela Ricci Domenico Marco Romeo Domenico Marco Romeo Teresa Spanu Teresa Spanu Luca Maggio Luca Maggio Eugenio Mercuri Eugenio Mercuri Giovanni Vento Giovanni Vento Maternal Ureaplasma/Mycoplasma colonization during pregnancy and neurodevelopmental outcomes for preterm infants Frontiers in Pediatrics neonate newborn neurodevelopment cognitive pregnant prematurity—risk assessment and prevention |
| title | Maternal Ureaplasma/Mycoplasma colonization during pregnancy and neurodevelopmental outcomes for preterm infants |
| title_full | Maternal Ureaplasma/Mycoplasma colonization during pregnancy and neurodevelopmental outcomes for preterm infants |
| title_fullStr | Maternal Ureaplasma/Mycoplasma colonization during pregnancy and neurodevelopmental outcomes for preterm infants |
| title_full_unstemmed | Maternal Ureaplasma/Mycoplasma colonization during pregnancy and neurodevelopmental outcomes for preterm infants |
| title_short | Maternal Ureaplasma/Mycoplasma colonization during pregnancy and neurodevelopmental outcomes for preterm infants |
| title_sort | maternal ureaplasma mycoplasma colonization during pregnancy and neurodevelopmental outcomes for preterm infants |
| topic | neonate newborn neurodevelopment cognitive pregnant prematurity—risk assessment and prevention |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.893812/full |
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