Relevance of BET Family Proteins in SARS-CoV-2 Infection
The recent pandemic we are experiencing caused by the coronavirus disease 2019 (COVID-19) has put the world’s population on the rack, with more than 191 million cases and more than 4.1 million deaths confirmed to date. This disease is caused by a new type of coronavirus, the severe acute respiratory...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/11/8/1126 |
| _version_ | 1827685814072508416 |
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| author | Nieves Lara-Ureña Mario García-Domínguez |
| author_facet | Nieves Lara-Ureña Mario García-Domínguez |
| author_sort | Nieves Lara-Ureña |
| collection | DOAJ |
| description | The recent pandemic we are experiencing caused by the coronavirus disease 2019 (COVID-19) has put the world’s population on the rack, with more than 191 million cases and more than 4.1 million deaths confirmed to date. This disease is caused by a new type of coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A massive proteomic analysis has revealed that one of the structural proteins of the virus, the E protein, interacts with BRD2 and BRD4 proteins of the Bromodomain and Extra Terminal domain (BET) family of proteins. BETs are essential to cell cycle progression, inflammation and immune response and have also been strongly associated with infection by different types of viruses. The fundamental role BET proteins play in transcription makes them appropriate targets for the propagation strategies of some viruses. Recognition of histone acetylation by BET bromodomains is essential for transcription control. The development of drugs mimicking acetyl groups, and thereby able to displace BET proteins from chromatin, has boosted interest on BETs as attractive targets for therapeutic intervention. The success of these drugs against a variety of diseases in cellular and animal models has been recently enlarged with promising results from SARS-CoV-2 infection studies. |
| first_indexed | 2024-03-10T08:59:46Z |
| format | Article |
| id | doaj.art-ca352750332f4a369d101b0e68aa3612 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T08:59:46Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-ca352750332f4a369d101b0e68aa36122023-11-22T06:55:12ZengMDPI AGBiomolecules2218-273X2021-07-01118112610.3390/biom11081126Relevance of BET Family Proteins in SARS-CoV-2 InfectionNieves Lara-Ureña0Mario García-Domínguez1Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER), CSIC-Universidad de Sevilla-Universidad Pablo de Olavide, Av. Américo Vespucio 24, 41092 Seville, SpainAndalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER), CSIC-Universidad de Sevilla-Universidad Pablo de Olavide, Av. Américo Vespucio 24, 41092 Seville, SpainThe recent pandemic we are experiencing caused by the coronavirus disease 2019 (COVID-19) has put the world’s population on the rack, with more than 191 million cases and more than 4.1 million deaths confirmed to date. This disease is caused by a new type of coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A massive proteomic analysis has revealed that one of the structural proteins of the virus, the E protein, interacts with BRD2 and BRD4 proteins of the Bromodomain and Extra Terminal domain (BET) family of proteins. BETs are essential to cell cycle progression, inflammation and immune response and have also been strongly associated with infection by different types of viruses. The fundamental role BET proteins play in transcription makes them appropriate targets for the propagation strategies of some viruses. Recognition of histone acetylation by BET bromodomains is essential for transcription control. The development of drugs mimicking acetyl groups, and thereby able to displace BET proteins from chromatin, has boosted interest on BETs as attractive targets for therapeutic intervention. The success of these drugs against a variety of diseases in cellular and animal models has been recently enlarged with promising results from SARS-CoV-2 infection studies.https://www.mdpi.com/2218-273X/11/8/1126SARS-CoV-2COVID-19BETBET inhibitorsBRD4BRD2 |
| spellingShingle | Nieves Lara-Ureña Mario García-Domínguez Relevance of BET Family Proteins in SARS-CoV-2 Infection Biomolecules SARS-CoV-2 COVID-19 BET BET inhibitors BRD4 BRD2 |
| title | Relevance of BET Family Proteins in SARS-CoV-2 Infection |
| title_full | Relevance of BET Family Proteins in SARS-CoV-2 Infection |
| title_fullStr | Relevance of BET Family Proteins in SARS-CoV-2 Infection |
| title_full_unstemmed | Relevance of BET Family Proteins in SARS-CoV-2 Infection |
| title_short | Relevance of BET Family Proteins in SARS-CoV-2 Infection |
| title_sort | relevance of bet family proteins in sars cov 2 infection |
| topic | SARS-CoV-2 COVID-19 BET BET inhibitors BRD4 BRD2 |
| url | https://www.mdpi.com/2218-273X/11/8/1126 |
| work_keys_str_mv | AT nieveslaraurena relevanceofbetfamilyproteinsinsarscov2infection AT mariogarciadominguez relevanceofbetfamilyproteinsinsarscov2infection |