Improvement Effect of Soyeom Pharmacopuncture on Gout via NLRP3 Inflammasome Regulation
Objectives: Gout is an inflammatory arthritis of the joints and soft tissues occurring due to deposition of monosodium urate (MSU) crystals, which are caused by persistent hyperuricemia. Soyeom pharmacopuncture is one treatment method that has been traditionally used for pain management in Oriental...
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| Format: | Article |
| Language: | English |
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Korean Pharmacopuncture Institute
2022-12-01
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| Series: | Journal of Pharmacopuncture |
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| Online Access: | http://journaleditor.inforang.com/journal/view.html?doi=10.3831/KPI.2022.25.4.396 |
| _version_ | 1797975211251859456 |
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| author | Sung Wook Kim Jun Ho Lee Hyeonjin Kim Seong Hoon Lee Dajeong Jeong Hyuk Soon Kim Cheol-Jung Lee Dae Yong Kim Tae Han Yook Gabsik Yang |
| author_facet | Sung Wook Kim Jun Ho Lee Hyeonjin Kim Seong Hoon Lee Dajeong Jeong Hyuk Soon Kim Cheol-Jung Lee Dae Yong Kim Tae Han Yook Gabsik Yang |
| author_sort | Sung Wook Kim |
| collection | DOAJ |
| description | Objectives: Gout is an inflammatory arthritis of the joints and soft tissues occurring due to deposition of monosodium urate (MSU) crystals, which are caused by persistent hyperuricemia. Soyeom pharmacopuncture is one treatment method that has been traditionally used for pain management in Oriental medicine. However, studies on its effect in reducing gout pain have been insufficient. Therefore, we selected Soyeom pharmacopuncture among natural products used in Korea as the new target of our study.Methods: The effects of Soyeom pharmacopuncture were examined in mouse models of acute gout induced by injection of MSU crystals into footpads. IL-1β, IL-6, and TNF-α production were examined by immunoblotting and enzyme-linked immunosorbent assay as hallmarks of NLRP3 inflammasome and cytokine activation.Results: Soyeom pharmacopuncture reduced foot edema in gout-induced mice, as well as IL-1β, nitrite, IL-6, and TNF-α production. Moreover, Soyeom pharmacopuncture also reduced MSU-induced gout inflammatory gene expressions, specifically those in the NF-kB pathway.Conclusion: Pharmacopuncture may serve as a new solution for other inflammatory diseases as well. Through active follow-up studies, we could thoroughly understand the clinical value of Soyeom pharmacopuncture. |
| first_indexed | 2024-04-11T04:31:54Z |
| format | Article |
| id | doaj.art-ca37467be32648af9c16b26efa18bd39 |
| institution | Directory Open Access Journal |
| issn | 2093-6966 |
| language | English |
| last_indexed | 2024-04-11T04:31:54Z |
| publishDate | 2022-12-01 |
| publisher | Korean Pharmacopuncture Institute |
| record_format | Article |
| series | Journal of Pharmacopuncture |
| spelling | doaj.art-ca37467be32648af9c16b26efa18bd392022-12-29T06:50:17ZengKorean Pharmacopuncture InstituteJournal of Pharmacopuncture2093-69662022-12-0125439640310.3831/KPI.2022.25.4.396KPI.2022.25.4.396Improvement Effect of Soyeom Pharmacopuncture on Gout via NLRP3 Inflammasome RegulationSung Wook Kim0Jun Ho Lee1Hyeonjin Kim2Seong Hoon Lee3Dajeong Jeong4Hyuk Soon Kim5Cheol-Jung Lee6Dae Yong Kim7Tae Han Yook8Gabsik Yang9Department of Korean Medicine, College of Korean Medicine, Woosuk University, Jeonju, Republic of KoreaDepartment of Korean Medicine, College of Korean Medicine, Woosuk University, Jeonju, Republic of KoreaDepartment of Korean Medicine, College of Korean Medicine, Woosuk University, Jeonju, Republic of KoreaDepartment of Korean Medicine, College of Korean Medicine, Woosuk University, Jeonju, Republic of KoreaDepartment of Korean Medicine, College of Korean Medicine, Woosuk University, Jeonju, Republic of KoreaDepartment of Biomedical Sciences, College of Natural Science and Department of Health Sciences, The Graduate School of Dong-A University, Busan, Republic of KoreaResearch Center for Materials Analysis, Korea Basic Science Institute, Daejeon, Republic of KoreaDepartment of Korean Medicine, College of Korean Medicine, Woosuk University, Jeonju, Republic of KoreaDepartment of Korean Medicine, College of Korean Medicine, Woosuk University, Jeonju, Republic of KoreaDepartment of Korean Medicine, College of Korean Medicine, Woosuk University, Jeonju, Republic of KoreaObjectives: Gout is an inflammatory arthritis of the joints and soft tissues occurring due to deposition of monosodium urate (MSU) crystals, which are caused by persistent hyperuricemia. Soyeom pharmacopuncture is one treatment method that has been traditionally used for pain management in Oriental medicine. However, studies on its effect in reducing gout pain have been insufficient. Therefore, we selected Soyeom pharmacopuncture among natural products used in Korea as the new target of our study.Methods: The effects of Soyeom pharmacopuncture were examined in mouse models of acute gout induced by injection of MSU crystals into footpads. IL-1β, IL-6, and TNF-α production were examined by immunoblotting and enzyme-linked immunosorbent assay as hallmarks of NLRP3 inflammasome and cytokine activation.Results: Soyeom pharmacopuncture reduced foot edema in gout-induced mice, as well as IL-1β, nitrite, IL-6, and TNF-α production. Moreover, Soyeom pharmacopuncture also reduced MSU-induced gout inflammatory gene expressions, specifically those in the NF-kB pathway.Conclusion: Pharmacopuncture may serve as a new solution for other inflammatory diseases as well. Through active follow-up studies, we could thoroughly understand the clinical value of Soyeom pharmacopuncture.http://journaleditor.inforang.com/journal/view.html?doi=10.3831/KPI.2022.25.4.396goutmonosodium uratenlrp3inflammasomesoyeompharmacopuncture |
| spellingShingle | Sung Wook Kim Jun Ho Lee Hyeonjin Kim Seong Hoon Lee Dajeong Jeong Hyuk Soon Kim Cheol-Jung Lee Dae Yong Kim Tae Han Yook Gabsik Yang Improvement Effect of Soyeom Pharmacopuncture on Gout via NLRP3 Inflammasome Regulation Journal of Pharmacopuncture gout monosodium urate nlrp3 inflammasome soyeom pharmacopuncture |
| title | Improvement Effect of Soyeom Pharmacopuncture on Gout via NLRP3 Inflammasome Regulation |
| title_full | Improvement Effect of Soyeom Pharmacopuncture on Gout via NLRP3 Inflammasome Regulation |
| title_fullStr | Improvement Effect of Soyeom Pharmacopuncture on Gout via NLRP3 Inflammasome Regulation |
| title_full_unstemmed | Improvement Effect of Soyeom Pharmacopuncture on Gout via NLRP3 Inflammasome Regulation |
| title_short | Improvement Effect of Soyeom Pharmacopuncture on Gout via NLRP3 Inflammasome Regulation |
| title_sort | improvement effect of soyeom pharmacopuncture on gout via nlrp3 inflammasome regulation |
| topic | gout monosodium urate nlrp3 inflammasome soyeom pharmacopuncture |
| url | http://journaleditor.inforang.com/journal/view.html?doi=10.3831/KPI.2022.25.4.396 |
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