Radioprotective profile of Urtica dioica L. seed extract on oxidative DNA-damage in liver tissue and whole blood of radiation-administered rats
It was aimed to investigate the radioprotective activity of Urtica dioica L. seed extract (UDSE) in the whole blood and liver of radiation-administered rats, both biochemically and immunohistochemically. 32 rats were divided into 4 groups (n:8). Control group (C): no administration for 10 days. Radi...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2020-04-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100558&tlng=en |
| _version_ | 1811271372835389440 |
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| author | Tahir Çakır Kenan Yıldızhan Zübeyir Huyut Ahmet Uyar Okan Arıhan |
| author_facet | Tahir Çakır Kenan Yıldızhan Zübeyir Huyut Ahmet Uyar Okan Arıhan |
| author_sort | Tahir Çakır |
| collection | DOAJ |
| description | It was aimed to investigate the radioprotective activity of Urtica dioica L. seed extract (UDSE) in the whole blood and liver of radiation-administered rats, both biochemically and immunohistochemically. 32 rats were divided into 4 groups (n:8). Control group (C): no administration for 10 days. Radiation group (IR): fed pellets for 10 days after exposure to radiation. Radiation + UDSE (IR+UDSE) group: exposed to radiation and fed UDSE for 10 days. UDSE group (UDSE): fed UDSE for 10 days. Radiation (5Gy) was given as a single fraction. 8-hydroxy-2-deoxyguanosine (8-OHdG) and deoxyguanosine (dG) levels were analyzed by biochemical method and glutathione peroxidase 1 (GPx-1) analyses were performed by immunohistochemical method in the liver and blood tissues of the rats. The increased 8-OHdG rates and decreased GPx-1 immunoreactivity was observed in the IR group. Those parameters were ameliorated in the IR+UDSE group when compared to the IR group. UDSE is likely to be a valuable radioprotector against the harmful effects of radiation. |
| first_indexed | 2024-04-12T22:20:02Z |
| format | Article |
| id | doaj.art-ca378cced67d40959050c2be35972edc |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-12T22:20:02Z |
| publishDate | 2020-04-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-ca378cced67d40959050c2be35972edc2022-12-22T03:14:25ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902020-04-015610.1590/s2175-97902019000318382Radioprotective profile of Urtica dioica L. seed extract on oxidative DNA-damage in liver tissue and whole blood of radiation-administered ratsTahir Çakırhttps://orcid.org/0000-0003-0080-6605Kenan Yıldızhanhttps://orcid.org/0000-0002-6585-4010Zübeyir Huyuthttps://orcid.org/0000-0002-7623-1492Ahmet Uyarhttps://orcid.org/0000-0003-4345-6756Okan Arıhanhttps://orcid.org/0000-0001-6201-7383It was aimed to investigate the radioprotective activity of Urtica dioica L. seed extract (UDSE) in the whole blood and liver of radiation-administered rats, both biochemically and immunohistochemically. 32 rats were divided into 4 groups (n:8). Control group (C): no administration for 10 days. Radiation group (IR): fed pellets for 10 days after exposure to radiation. Radiation + UDSE (IR+UDSE) group: exposed to radiation and fed UDSE for 10 days. UDSE group (UDSE): fed UDSE for 10 days. Radiation (5Gy) was given as a single fraction. 8-hydroxy-2-deoxyguanosine (8-OHdG) and deoxyguanosine (dG) levels were analyzed by biochemical method and glutathione peroxidase 1 (GPx-1) analyses were performed by immunohistochemical method in the liver and blood tissues of the rats. The increased 8-OHdG rates and decreased GPx-1 immunoreactivity was observed in the IR group. Those parameters were ameliorated in the IR+UDSE group when compared to the IR group. UDSE is likely to be a valuable radioprotector against the harmful effects of radiation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100558&tlng=enRadioprotectiveDNA damageAntioxidantUrtica |
| spellingShingle | Tahir Çakır Kenan Yıldızhan Zübeyir Huyut Ahmet Uyar Okan Arıhan Radioprotective profile of Urtica dioica L. seed extract on oxidative DNA-damage in liver tissue and whole blood of radiation-administered rats Brazilian Journal of Pharmaceutical Sciences Radioprotective DNA damage Antioxidant Urtica |
| title | Radioprotective profile of Urtica dioica L. seed extract on oxidative DNA-damage in liver tissue and whole blood of radiation-administered rats |
| title_full | Radioprotective profile of Urtica dioica L. seed extract on oxidative DNA-damage in liver tissue and whole blood of radiation-administered rats |
| title_fullStr | Radioprotective profile of Urtica dioica L. seed extract on oxidative DNA-damage in liver tissue and whole blood of radiation-administered rats |
| title_full_unstemmed | Radioprotective profile of Urtica dioica L. seed extract on oxidative DNA-damage in liver tissue and whole blood of radiation-administered rats |
| title_short | Radioprotective profile of Urtica dioica L. seed extract on oxidative DNA-damage in liver tissue and whole blood of radiation-administered rats |
| title_sort | radioprotective profile of urtica dioica l seed extract on oxidative dna damage in liver tissue and whole blood of radiation administered rats |
| topic | Radioprotective DNA damage Antioxidant Urtica |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100558&tlng=en |
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