Paternal Occupational Exposure to Heavy Metals and Welding Fumes and Testicular Germ Cell Tumours in Sons in France
Testicular cancer is the most common cancer in young men. Its causes are largely unknown, although prenatal occupational and environmental exposures have been suggested. We investigated paternal occupational exposure to heavy metals and welding fumes and the risk of testicular germ cell tumors (TGCT...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/19/4962 |
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| author | Shukrullah Ahmadi Margot Guth Astrid Coste Liacine Bouaoun Aurélie Danjou Marie Lefevre Brigitte Dananché Delphine Praud Martie Van Tongeren Louis Bujan Olivia Pérol Joachim Schüz Barbara Charbotel Béatrice Fervers Ann Olsson the TESTIS Study Group |
| author_facet | Shukrullah Ahmadi Margot Guth Astrid Coste Liacine Bouaoun Aurélie Danjou Marie Lefevre Brigitte Dananché Delphine Praud Martie Van Tongeren Louis Bujan Olivia Pérol Joachim Schüz Barbara Charbotel Béatrice Fervers Ann Olsson the TESTIS Study Group |
| author_sort | Shukrullah Ahmadi |
| collection | DOAJ |
| description | Testicular cancer is the most common cancer in young men. Its causes are largely unknown, although prenatal occupational and environmental exposures have been suggested. We investigated paternal occupational exposure to heavy metals and welding fumes and the risk of testicular germ cell tumors (TGCT) in their offspring. A total of 454 cases and 670 controls were included from a French nationwide case–control study. The INTEROCC job exposure matrix was used to assign occupational exposures (cadmium, chromium, iron, nickel, lead, and welding fumes) to the fathers’ jobs. Odds ratios (ORs) for TGCT were estimated using conditional logistic regression models for frequency-matched sets. Three complementary analytical approaches were used: (1) single-agent analysis, (2) analysis by groups, and (3) principal component analysis (PCA). The proportion of paternal exposure to different heavy metals and welding fumes ranged from 0.7% (cadmium) to 11.3% (lead). Based on PCA, three principal components explained 93.5% of the cumulative variance. No associations were found between heavy metals or welding fumes and TGCT. In this study, paternal occupational exposure to heavy metals or welding fumes was not associated with TGCT development in their sons. |
| first_indexed | 2024-03-09T21:55:07Z |
| format | Article |
| id | doaj.art-ca3a9aa741f345d89d8383df0402a021 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T21:55:07Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ca3a9aa741f345d89d8383df0402a0212023-11-23T19:59:35ZengMDPI AGCancers2072-66942022-10-011419496210.3390/cancers14194962Paternal Occupational Exposure to Heavy Metals and Welding Fumes and Testicular Germ Cell Tumours in Sons in FranceShukrullah Ahmadi0Margot Guth1Astrid Coste2Liacine Bouaoun3Aurélie Danjou4Marie Lefevre5Brigitte Dananché6Delphine Praud7Martie Van Tongeren8Louis Bujan9Olivia Pérol10Joachim Schüz11Barbara Charbotel12Béatrice Fervers13Ann Olsson14the TESTIS Study GroupEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer IARC/WHO, 150 cours Albert Thomas, CEDEX 08, 69372 Lyon, FranceUMRESTTE, UMR T 9405, IFSTTAR, Lyon 1 University, Eiffel University, 69008 Lyon, FranceDépartement Prévention, Cancer et Environnement, Centre Léon Bérard, 69008 Lyon, FranceEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer IARC/WHO, 150 cours Albert Thomas, CEDEX 08, 69372 Lyon, FranceEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer IARC/WHO, 150 cours Albert Thomas, CEDEX 08, 69372 Lyon, FranceUMRESTTE, UMR T 9405, IFSTTAR, Lyon 1 University, Eiffel University, 69008 Lyon, FranceINSERM UMR1296 Radiation: Defense, Health, Environment, 69008 Lyon, FranceDépartement Prévention, Cancer et Environnement, Centre Léon Bérard, 69008 Lyon, FranceCentre for Human Exposure Science, Institute of Occupational Medicine (IOM), Research Avenue North, Riccarton, Edinburgh EH14 4AP, UKDEFE (Développement Embryonnaire, Fertilité, Environnement) INSERM 1203, Universités Montpellier et Toulouse 3, 31000 Toulouse, FranceDépartement Prévention, Cancer et Environnement, Centre Léon Bérard, 69008 Lyon, FranceEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer IARC/WHO, 150 cours Albert Thomas, CEDEX 08, 69372 Lyon, FranceUMRESTTE, UMR T 9405, IFSTTAR, Lyon 1 University, Eiffel University, 69008 Lyon, FranceDépartement Prévention, Cancer et Environnement, Centre Léon Bérard, 69008 Lyon, FranceEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer IARC/WHO, 150 cours Albert Thomas, CEDEX 08, 69372 Lyon, FranceTesticular cancer is the most common cancer in young men. Its causes are largely unknown, although prenatal occupational and environmental exposures have been suggested. We investigated paternal occupational exposure to heavy metals and welding fumes and the risk of testicular germ cell tumors (TGCT) in their offspring. A total of 454 cases and 670 controls were included from a French nationwide case–control study. The INTEROCC job exposure matrix was used to assign occupational exposures (cadmium, chromium, iron, nickel, lead, and welding fumes) to the fathers’ jobs. Odds ratios (ORs) for TGCT were estimated using conditional logistic regression models for frequency-matched sets. Three complementary analytical approaches were used: (1) single-agent analysis, (2) analysis by groups, and (3) principal component analysis (PCA). The proportion of paternal exposure to different heavy metals and welding fumes ranged from 0.7% (cadmium) to 11.3% (lead). Based on PCA, three principal components explained 93.5% of the cumulative variance. No associations were found between heavy metals or welding fumes and TGCT. In this study, paternal occupational exposure to heavy metals or welding fumes was not associated with TGCT development in their sons.https://www.mdpi.com/2072-6694/14/19/4962paternal occupational exposureheavy metalswelding fumestesticular germ cell tumorscase–control study |
| spellingShingle | Shukrullah Ahmadi Margot Guth Astrid Coste Liacine Bouaoun Aurélie Danjou Marie Lefevre Brigitte Dananché Delphine Praud Martie Van Tongeren Louis Bujan Olivia Pérol Joachim Schüz Barbara Charbotel Béatrice Fervers Ann Olsson the TESTIS Study Group Paternal Occupational Exposure to Heavy Metals and Welding Fumes and Testicular Germ Cell Tumours in Sons in France Cancers paternal occupational exposure heavy metals welding fumes testicular germ cell tumors case–control study |
| title | Paternal Occupational Exposure to Heavy Metals and Welding Fumes and Testicular Germ Cell Tumours in Sons in France |
| title_full | Paternal Occupational Exposure to Heavy Metals and Welding Fumes and Testicular Germ Cell Tumours in Sons in France |
| title_fullStr | Paternal Occupational Exposure to Heavy Metals and Welding Fumes and Testicular Germ Cell Tumours in Sons in France |
| title_full_unstemmed | Paternal Occupational Exposure to Heavy Metals and Welding Fumes and Testicular Germ Cell Tumours in Sons in France |
| title_short | Paternal Occupational Exposure to Heavy Metals and Welding Fumes and Testicular Germ Cell Tumours in Sons in France |
| title_sort | paternal occupational exposure to heavy metals and welding fumes and testicular germ cell tumours in sons in france |
| topic | paternal occupational exposure heavy metals welding fumes testicular germ cell tumors case–control study |
| url | https://www.mdpi.com/2072-6694/14/19/4962 |
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