Malus Domestica Peel Extract Counters Carboplatin Induced Fall in Red Blood Cell Count and Bone Marrow Erythroid Cell Percentage in Mice
Introduction: The Chemotherapy-Induced Anemia (CIA) is a complex phenomenon impacted by many treatments and patient related variables. Some variations within CIA are type of chemotherapeutic agent, dose and schedule of administration of agent, type as well as stage of cancer, time of intervention, a...
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Shaikh Zayed Medical Complex, Lahore
2021-06-01
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| Series: | Proceedings |
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| Online Access: | https://proceedings-szmc.org.pk/index.php/szmc/article/view/135 |
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| author | Abdul Mudabbir Rehan Fariha Ahmad Khan Qudsia Umaira Khan Rabia Naseer Khan Zoobia Irum Sehrish Zaffar Sadia Chiragh |
| author_facet | Abdul Mudabbir Rehan Fariha Ahmad Khan Qudsia Umaira Khan Rabia Naseer Khan Zoobia Irum Sehrish Zaffar Sadia Chiragh |
| author_sort | Abdul Mudabbir Rehan |
| collection | DOAJ |
| description | Introduction: The Chemotherapy-Induced Anemia (CIA) is a complex phenomenon impacted by many treatments and patient related variables. Some variations within CIA are type of chemotherapeutic agent, dose and schedule of administration of agent, type as well as stage of cancer, time of intervention, age, gender, nutritional status and renal function. The variety of patient presentation and symptomatology in CIA is very thought-provoking while setting up widespread measures to oversee ideal administration of treatments. This study will be focused on protective role of apple peel extract (APPE) on carboplatin induced fall in blood RBC count bone marrow erythroid cell percentage in mice.
Aims & Objective: To evaluate the protective effect of Malus domestica peel extract on carboplatin induced fall in red blood cell count and bone marrow erythroid cell percentage in mice.
Place and duration of study: The study was conducted at Pharmacology Department of Postgraduate Medical institute, Lahore in June 2016. The total duration of study was 1 month.
Material & Methods: Forty adult male mice were randomly divided into 5 groups (n=8) and maintained on standard diet and water adlibitum. Group A was negative control. Group B was disease control wherein each animal received one dose of 125mg/kg carboplatin intraperitoneally. Group C, D & E experimental groups were administered same dose carboplatin followed by the ethanolic apple peel extract in three different single oral doses of 25, 50 & 75mg/kg respectively for 7 days. Blood & tissue sampling was done on the 8th day. Data was analyzed using Graf Pad prism 7.
Results: Acute Carboplatin anaemia resulted in 4.01±0.851012/L RBC Count & 21.6±1.06% bone marrow erythroid cell percentage in Disease Control Group B. Subsequent Apple peel extract administration in a dose of 25, 50 and 75mg/kg\ countered carboplatin induced fall in Groups C, D & E, simultaneously raising RBC counts & bone marrow erythroid cell percentage to (6.19±0.70×1012/L & 21.3±1.28%) (6.56±0.37×1012/L & 25.3±1.04%) and (6.26±0.74×1012/L & 23.5±1.41%.) respectively. The increase in RBC as well as erythroid cell counts was most significant with the dose of 50mg/kg and nearing that of healthy control levels (Group A)
Conclusion: Apple Peel Extract effectively prevented carboplatin induced fall in RBC count and erythroid cell
percentage and produced most significant results in a dose of 50 mg/kg. |
| first_indexed | 2024-04-11T10:09:58Z |
| format | Article |
| id | doaj.art-ca3b65f49621413baae85fd44cbadc2e |
| institution | Directory Open Access Journal |
| issn | 1815-4905 2518-203X |
| language | English |
| last_indexed | 2024-04-11T10:09:58Z |
| publishDate | 2021-06-01 |
| publisher | Shaikh Zayed Medical Complex, Lahore |
| record_format | Article |
| series | Proceedings |
| spelling | doaj.art-ca3b65f49621413baae85fd44cbadc2e2022-12-22T04:30:07ZengShaikh Zayed Medical Complex, LahoreProceedings1815-49052518-203X2021-06-01353172310.47489/PSZMC-803-35-3-17-23135Malus Domestica Peel Extract Counters Carboplatin Induced Fall in Red Blood Cell Count and Bone Marrow Erythroid Cell Percentage in MiceAbdul Mudabbir Rehan0Fariha Ahmad Khan1Qudsia Umaira Khan2Rabia Naseer Khan3Zoobia Irum4Sehrish Zaffar5Sadia Chiragh6Department of Pharmacology, D.G. Khan Medical College, Dera Ghazi Khan.Department of Pharmacology, Akhtar Saeed Medical and Dental College, Lahore.Department of Physiology, CMH Medical College, Lahore.Department of Pathology, Shahida Islam Medical and Dental College, Lodhran.Department of Pharmacology, CMH Institute of Medical Sciences, Bahawalpur.Department of Physiology, CMH Medical College, Lahore.Department of Pharmacology, Al-Aleem Medical College, Lahore.Introduction: The Chemotherapy-Induced Anemia (CIA) is a complex phenomenon impacted by many treatments and patient related variables. Some variations within CIA are type of chemotherapeutic agent, dose and schedule of administration of agent, type as well as stage of cancer, time of intervention, age, gender, nutritional status and renal function. The variety of patient presentation and symptomatology in CIA is very thought-provoking while setting up widespread measures to oversee ideal administration of treatments. This study will be focused on protective role of apple peel extract (APPE) on carboplatin induced fall in blood RBC count bone marrow erythroid cell percentage in mice. Aims & Objective: To evaluate the protective effect of Malus domestica peel extract on carboplatin induced fall in red blood cell count and bone marrow erythroid cell percentage in mice. Place and duration of study: The study was conducted at Pharmacology Department of Postgraduate Medical institute, Lahore in June 2016. The total duration of study was 1 month. Material & Methods: Forty adult male mice were randomly divided into 5 groups (n=8) and maintained on standard diet and water adlibitum. Group A was negative control. Group B was disease control wherein each animal received one dose of 125mg/kg carboplatin intraperitoneally. Group C, D & E experimental groups were administered same dose carboplatin followed by the ethanolic apple peel extract in three different single oral doses of 25, 50 & 75mg/kg respectively for 7 days. Blood & tissue sampling was done on the 8th day. Data was analyzed using Graf Pad prism 7. Results: Acute Carboplatin anaemia resulted in 4.01±0.851012/L RBC Count & 21.6±1.06% bone marrow erythroid cell percentage in Disease Control Group B. Subsequent Apple peel extract administration in a dose of 25, 50 and 75mg/kg\ countered carboplatin induced fall in Groups C, D & E, simultaneously raising RBC counts & bone marrow erythroid cell percentage to (6.19±0.70×1012/L & 21.3±1.28%) (6.56±0.37×1012/L & 25.3±1.04%) and (6.26±0.74×1012/L & 23.5±1.41%.) respectively. The increase in RBC as well as erythroid cell counts was most significant with the dose of 50mg/kg and nearing that of healthy control levels (Group A) Conclusion: Apple Peel Extract effectively prevented carboplatin induced fall in RBC count and erythroid cell percentage and produced most significant results in a dose of 50 mg/kg.https://proceedings-szmc.org.pk/index.php/szmc/article/view/135chemotherapy induced anemia (cia), carboplatin, malus domestica, erythroid cell percentage. |
| spellingShingle | Abdul Mudabbir Rehan Fariha Ahmad Khan Qudsia Umaira Khan Rabia Naseer Khan Zoobia Irum Sehrish Zaffar Sadia Chiragh Malus Domestica Peel Extract Counters Carboplatin Induced Fall in Red Blood Cell Count and Bone Marrow Erythroid Cell Percentage in Mice Proceedings chemotherapy induced anemia (cia), carboplatin, malus domestica, erythroid cell percentage. |
| title | Malus Domestica Peel Extract Counters Carboplatin Induced Fall in Red Blood Cell Count and Bone Marrow Erythroid Cell Percentage in Mice |
| title_full | Malus Domestica Peel Extract Counters Carboplatin Induced Fall in Red Blood Cell Count and Bone Marrow Erythroid Cell Percentage in Mice |
| title_fullStr | Malus Domestica Peel Extract Counters Carboplatin Induced Fall in Red Blood Cell Count and Bone Marrow Erythroid Cell Percentage in Mice |
| title_full_unstemmed | Malus Domestica Peel Extract Counters Carboplatin Induced Fall in Red Blood Cell Count and Bone Marrow Erythroid Cell Percentage in Mice |
| title_short | Malus Domestica Peel Extract Counters Carboplatin Induced Fall in Red Blood Cell Count and Bone Marrow Erythroid Cell Percentage in Mice |
| title_sort | malus domestica peel extract counters carboplatin induced fall in red blood cell count and bone marrow erythroid cell percentage in mice |
| topic | chemotherapy induced anemia (cia), carboplatin, malus domestica, erythroid cell percentage. |
| url | https://proceedings-szmc.org.pk/index.php/szmc/article/view/135 |
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