Cannabis use is associated with sexually dimorphic changes in executive control of visuospatial decision-making
When the outcome of a choice is less favorable than expected, humans and animals typically shift to an alternate choice option on subsequent trials. Several lines of evidence indicate that this “lose-shift” responding is an innate sensorimotor response strategy that is normally suppressed by executi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnint.2022.884080/full |
| _version_ | 1811283646410129408 |
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| author | Parker J. Banks Patrick J. Bennett Allison B. Sekuler Allison B. Sekuler Allison B. Sekuler Aaron J. Gruber |
| author_facet | Parker J. Banks Patrick J. Bennett Allison B. Sekuler Allison B. Sekuler Allison B. Sekuler Aaron J. Gruber |
| author_sort | Parker J. Banks |
| collection | DOAJ |
| description | When the outcome of a choice is less favorable than expected, humans and animals typically shift to an alternate choice option on subsequent trials. Several lines of evidence indicate that this “lose-shift” responding is an innate sensorimotor response strategy that is normally suppressed by executive function. Therefore, the lose-shift response provides a covert gauge of cognitive control over choice mechanisms. We report here that the spatial position, rather than visual features, of choice targets drives the lose-shift effect. Furthermore, the ability to inhibit lose-shift responding to gain reward is different among male and female habitual cannabis users. Increased self-reported cannabis use was concordant with suppressed response flexibility and an increased tendency to lose-shift in women, which reduced performance in a choice task in which random responding is the optimal strategy. On the other hand, increased cannabis use in men was concordant with reduced reliance on spatial cues during decision-making, and had no impact on the number of correct responses. These data (63,600 trials from 106 participants) provide strong evidence that spatial-motor processing is an important component of economic decision-making, and that its governance by executive systems is different in men and women who use cannabis frequently. |
| first_indexed | 2024-04-13T02:15:09Z |
| format | Article |
| id | doaj.art-ca3cb94829384e9b92f31cd25715ad0e |
| institution | Directory Open Access Journal |
| issn | 1662-5145 |
| language | English |
| last_indexed | 2024-04-13T02:15:09Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Integrative Neuroscience |
| spelling | doaj.art-ca3cb94829384e9b92f31cd25715ad0e2022-12-22T03:07:11ZengFrontiers Media S.A.Frontiers in Integrative Neuroscience1662-51452022-08-011610.3389/fnint.2022.884080884080Cannabis use is associated with sexually dimorphic changes in executive control of visuospatial decision-makingParker J. Banks0Patrick J. Bennett1Allison B. Sekuler2Allison B. Sekuler3Allison B. Sekuler4Aaron J. Gruber5Vision and Cognitive Neuroscience Lab, Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, ON, CanadaVision and Cognitive Neuroscience Lab, Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, ON, CanadaVision and Cognitive Neuroscience Lab, Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, ON, CanadaRotman Research Institute, Baycrest Centre for Geriatric Care, North York, ON, CanadaDepartment of Psychology, University of Toronto, Toronto, ON, CanadaDepartment of Neuroscience, University of Lethbridge, Lethbridge, AB, CanadaWhen the outcome of a choice is less favorable than expected, humans and animals typically shift to an alternate choice option on subsequent trials. Several lines of evidence indicate that this “lose-shift” responding is an innate sensorimotor response strategy that is normally suppressed by executive function. Therefore, the lose-shift response provides a covert gauge of cognitive control over choice mechanisms. We report here that the spatial position, rather than visual features, of choice targets drives the lose-shift effect. Furthermore, the ability to inhibit lose-shift responding to gain reward is different among male and female habitual cannabis users. Increased self-reported cannabis use was concordant with suppressed response flexibility and an increased tendency to lose-shift in women, which reduced performance in a choice task in which random responding is the optimal strategy. On the other hand, increased cannabis use in men was concordant with reduced reliance on spatial cues during decision-making, and had no impact on the number of correct responses. These data (63,600 trials from 106 participants) provide strong evidence that spatial-motor processing is an important component of economic decision-making, and that its governance by executive systems is different in men and women who use cannabis frequently.https://www.frontiersin.org/articles/10.3389/fnint.2022.884080/fullcannabislose-shiftaddictionexecutive controlspatial processingchoice |
| spellingShingle | Parker J. Banks Patrick J. Bennett Allison B. Sekuler Allison B. Sekuler Allison B. Sekuler Aaron J. Gruber Cannabis use is associated with sexually dimorphic changes in executive control of visuospatial decision-making Frontiers in Integrative Neuroscience cannabis lose-shift addiction executive control spatial processing choice |
| title | Cannabis use is associated with sexually dimorphic changes in executive control of visuospatial decision-making |
| title_full | Cannabis use is associated with sexually dimorphic changes in executive control of visuospatial decision-making |
| title_fullStr | Cannabis use is associated with sexually dimorphic changes in executive control of visuospatial decision-making |
| title_full_unstemmed | Cannabis use is associated with sexually dimorphic changes in executive control of visuospatial decision-making |
| title_short | Cannabis use is associated with sexually dimorphic changes in executive control of visuospatial decision-making |
| title_sort | cannabis use is associated with sexually dimorphic changes in executive control of visuospatial decision making |
| topic | cannabis lose-shift addiction executive control spatial processing choice |
| url | https://www.frontiersin.org/articles/10.3389/fnint.2022.884080/full |
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