Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies
Crimean-Congo hemorrhagic fever virus (CCHFV) is a widespread, tick-borne pathogen that causes Crimean-Congo hemorrhagic fever (CCHF) with high morbidity and mortality. CCHFV is transmitted to humans through tick bites or direct contact with patients or infected animals with viremia. Currently, clim...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/7/1195 |
| _version_ | 1827689099018895360 |
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| author | Shiyu Dai Fei Deng Hualin Wang Yunjia Ning |
| author_facet | Shiyu Dai Fei Deng Hualin Wang Yunjia Ning |
| author_sort | Shiyu Dai |
| collection | DOAJ |
| description | Crimean-Congo hemorrhagic fever virus (CCHFV) is a widespread, tick-borne pathogen that causes Crimean-Congo hemorrhagic fever (CCHF) with high morbidity and mortality. CCHFV is transmitted to humans through tick bites or direct contact with patients or infected animals with viremia. Currently, climate change and globalization have increased the transmission risk of this biosafety level (BSL)-4 virus. The treatment options of CCHFV infection remain limited and there is no FDA-approved vaccine or specific antivirals, which urges the identification of potential therapeutic targets and the design of CCHF therapies with greater effort. In this article, we discuss the current progress and some future directions in the development of antiviral strategies against CCHFV. |
| first_indexed | 2024-03-10T10:11:02Z |
| format | Article |
| id | doaj.art-ca3d905a33a34de19d9d00e0aa306990 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T10:11:02Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-ca3d905a33a34de19d9d00e0aa3069902023-11-22T01:12:49ZengMDPI AGViruses1999-49152021-06-01137119510.3390/v13071195Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral StrategiesShiyu Dai0Fei Deng1Hualin Wang2Yunjia Ning3State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, ChinaState Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, ChinaState Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, ChinaState Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, ChinaCrimean-Congo hemorrhagic fever virus (CCHFV) is a widespread, tick-borne pathogen that causes Crimean-Congo hemorrhagic fever (CCHF) with high morbidity and mortality. CCHFV is transmitted to humans through tick bites or direct contact with patients or infected animals with viremia. Currently, climate change and globalization have increased the transmission risk of this biosafety level (BSL)-4 virus. The treatment options of CCHFV infection remain limited and there is no FDA-approved vaccine or specific antivirals, which urges the identification of potential therapeutic targets and the design of CCHF therapies with greater effort. In this article, we discuss the current progress and some future directions in the development of antiviral strategies against CCHFV.https://www.mdpi.com/1999-4915/13/7/1195Crimean-Congo hemorrhagic fever virusbunyavirustick-borne virusantiviral strategies |
| spellingShingle | Shiyu Dai Fei Deng Hualin Wang Yunjia Ning Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies Viruses Crimean-Congo hemorrhagic fever virus bunyavirus tick-borne virus antiviral strategies |
| title | Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies |
| title_full | Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies |
| title_fullStr | Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies |
| title_full_unstemmed | Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies |
| title_short | Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies |
| title_sort | crimean congo hemorrhagic fever virus current advances and future prospects of antiviral strategies |
| topic | Crimean-Congo hemorrhagic fever virus bunyavirus tick-borne virus antiviral strategies |
| url | https://www.mdpi.com/1999-4915/13/7/1195 |
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