Amyloid Aβ<sub>25-35</sub> Aggregates Say ‘NO’ to Long-Term Potentiation in the Hippocampus through Activation of Stress-Induced Phosphatase 1 and Mitochondrial Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger

Amyloid Aβ<sub>25-35</sub> Aggregates Say ‘NO’ to Long-Term Potentiation in the Hippocampus through Activation of Stress-Induced Phosphatase 1 and Mitochondrial Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger

The search for strategies for strengthening the synaptic efficiency in Aβ<sub>25-35</sub>-treated slices is a challenge for the compensation of amyloidosis-related pathologies. Here, we used the recording of field excitatory postsynaptic potentials (fEPSPs), nitric oxide (NO) imaging, me...

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Bibliographic Details
Main Authors: Alexander V. Maltsev, Anna B. Nikiforova, Natalia V. Bal, Pavel M. Balaban
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
amyloid peptides
Alzheimer’s disease
field excitatory postsynaptic potentials
nitric oxide
serine/threonine phosphatases
mitochondrial Na<sup>+</sup>/Ca<sup>2+</sup> exchanger
Online Access:https://www.mdpi.com/1422-0067/23/19/11848

Internet

https://www.mdpi.com/1422-0067/23/19/11848

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