Spinal Cord Injury in Myelomeningocele: Prospects for Therapy
Myelomeningocele (MMC) is the most common congenital defect of the central nervous system and results in devastating and lifelong disability. In MMC, the initial failure of neural tube closure early in gestation is followed by a progressive prenatal injury to the exposed spinal cord, which contribut...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2020.00201/full |
| _version_ | 1818558984129347584 |
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| author | Karolina Janik Meredith A. Manire George M. Smith Barbara Krynska |
| author_facet | Karolina Janik Meredith A. Manire George M. Smith Barbara Krynska |
| author_sort | Karolina Janik |
| collection | DOAJ |
| description | Myelomeningocele (MMC) is the most common congenital defect of the central nervous system and results in devastating and lifelong disability. In MMC, the initial failure of neural tube closure early in gestation is followed by a progressive prenatal injury to the exposed spinal cord, which contributes to the deterioration of neurological function in fetuses. Prenatal strategies to control the spinal cord injury offer an appealing therapeutic approach to improve neurological function, although the definitive pathophysiological mechanisms of injury remain to be fully elucidated. A better understanding of these mechanisms at the cellular and molecular level is of paramount importance for the development of targeted prenatal MMC therapies to minimize or eliminate the effects of the injury and improve neurological function. In this review article, we discuss the pathological development of MMC with a focus on in utero injury to the exposed spinal cord. We emphasize the need for a better understanding of the causative factors in MMC spinal cord injury, pathophysiological alterations associated with the injury, and cellular and molecular mechanisms by which these alterations are induced. |
| first_indexed | 2024-12-14T00:19:26Z |
| format | Article |
| id | doaj.art-ca44bfd316214b24895983588ce830c4 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-14T00:19:26Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-ca44bfd316214b24895983588ce830c42022-12-21T23:25:18ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022020-06-011410.3389/fncel.2020.00201539171Spinal Cord Injury in Myelomeningocele: Prospects for TherapyKarolina Janik0Meredith A. Manire1George M. Smith2Barbara Krynska3Shriners Hospitals Pediatric Research Center, Center for Neural Repair and Rehabilitation, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United StatesDepartment of Obstetrics and Gynecology, West Penn Hospital, Allegheny Health Network, Pittsburgh, PA, United StatesShriners Hospitals Pediatric Research Center, Center for Neural Repair and Rehabilitation, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United StatesShriners Hospitals Pediatric Research Center, Center for Neural Repair and Rehabilitation, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United StatesMyelomeningocele (MMC) is the most common congenital defect of the central nervous system and results in devastating and lifelong disability. In MMC, the initial failure of neural tube closure early in gestation is followed by a progressive prenatal injury to the exposed spinal cord, which contributes to the deterioration of neurological function in fetuses. Prenatal strategies to control the spinal cord injury offer an appealing therapeutic approach to improve neurological function, although the definitive pathophysiological mechanisms of injury remain to be fully elucidated. A better understanding of these mechanisms at the cellular and molecular level is of paramount importance for the development of targeted prenatal MMC therapies to minimize or eliminate the effects of the injury and improve neurological function. In this review article, we discuss the pathological development of MMC with a focus on in utero injury to the exposed spinal cord. We emphasize the need for a better understanding of the causative factors in MMC spinal cord injury, pathophysiological alterations associated with the injury, and cellular and molecular mechanisms by which these alterations are induced.https://www.frontiersin.org/article/10.3389/fncel.2020.00201/fullmyelomeningocelespina bifidaneural tube defectsspinal cord injuryneural injury |
| spellingShingle | Karolina Janik Meredith A. Manire George M. Smith Barbara Krynska Spinal Cord Injury in Myelomeningocele: Prospects for Therapy Frontiers in Cellular Neuroscience myelomeningocele spina bifida neural tube defects spinal cord injury neural injury |
| title | Spinal Cord Injury in Myelomeningocele: Prospects for Therapy |
| title_full | Spinal Cord Injury in Myelomeningocele: Prospects for Therapy |
| title_fullStr | Spinal Cord Injury in Myelomeningocele: Prospects for Therapy |
| title_full_unstemmed | Spinal Cord Injury in Myelomeningocele: Prospects for Therapy |
| title_short | Spinal Cord Injury in Myelomeningocele: Prospects for Therapy |
| title_sort | spinal cord injury in myelomeningocele prospects for therapy |
| topic | myelomeningocele spina bifida neural tube defects spinal cord injury neural injury |
| url | https://www.frontiersin.org/article/10.3389/fncel.2020.00201/full |
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