Simultaneous Occurrence of Nanospheres and Nanofibers Self‐Assembled from Achiral Tripeptides
Abstract The achiral tripeptide Boc‐Aib‐MABA‐Aib‐OMe has the ability to co‐exist as nanospheres and as a network of nanofibers in methanol. Furthermore, AFM and TEM images show the presence of bulges in the network of nanofibers. Interestingly, the formation of nanofibers is seen to emerge from the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2019-03-01
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| Series: | ChemistryOpen |
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| Online Access: | https://doi.org/10.1002/open.201800258 |
| _version_ | 1797771190181298176 |
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| author | Malapaka Venkata Vardhishna Gannoju Srinivasulu Adicherl Harikrishna Suman Siddharth Thakur Bhaswati Chatterjee |
| author_facet | Malapaka Venkata Vardhishna Gannoju Srinivasulu Adicherl Harikrishna Suman Siddharth Thakur Bhaswati Chatterjee |
| author_sort | Malapaka Venkata Vardhishna |
| collection | DOAJ |
| description | Abstract The achiral tripeptide Boc‐Aib‐MABA‐Aib‐OMe has the ability to co‐exist as nanospheres and as a network of nanofibers in methanol. Furthermore, AFM and TEM images show the presence of bulges in the network of nanofibers. Interestingly, the formation of nanofibers is seen to emerge from the outer boundary of the spherical structures. Some of the nanofibers curl up at the tip and later result in the formation of hollow nanospheres with thick boundaries. The presence of β‐turn‐like structures with hydrogen bonding is observed using FT‐IR studies. The presence of hydrogen bonding is also demonstrated by using NMR studies. |
| first_indexed | 2024-03-12T21:33:54Z |
| format | Article |
| id | doaj.art-ca4665a2facd489086fefd8390307c95 |
| institution | Directory Open Access Journal |
| issn | 2191-1363 |
| language | English |
| last_indexed | 2024-03-12T21:33:54Z |
| publishDate | 2019-03-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | ChemistryOpen |
| spelling | doaj.art-ca4665a2facd489086fefd8390307c952023-07-27T14:18:46ZengWiley-VCHChemistryOpen2191-13632019-03-018326627010.1002/open.201800258Simultaneous Occurrence of Nanospheres and Nanofibers Self‐Assembled from Achiral TripeptidesMalapaka Venkata Vardhishna0Gannoju Srinivasulu1Adicherl Harikrishna2Suman Siddharth Thakur3Bhaswati Chatterjee4National Institute of Pharmaceutical Education and Research (NIPER) NIPER-Hyderabad Dept. of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India Balanagar Hyderabad – 500 037, Telangana IndiaNational Institute of Pharmaceutical Education and Research (NIPER) NIPER-Hyderabad Dept. of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India Balanagar Hyderabad – 500 037, Telangana IndiaProteomics and Cell Signaling, Lab E409 Centre for Cellular and Molecular Biology Uppal Road Hyderabad – 500007 IndiaProteomics and Cell Signaling, Lab E409 Centre for Cellular and Molecular Biology Uppal Road Hyderabad – 500007 IndiaNational Institute of Pharmaceutical Education and Research (NIPER) NIPER-Hyderabad Dept. of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India Balanagar Hyderabad – 500 037, Telangana IndiaAbstract The achiral tripeptide Boc‐Aib‐MABA‐Aib‐OMe has the ability to co‐exist as nanospheres and as a network of nanofibers in methanol. Furthermore, AFM and TEM images show the presence of bulges in the network of nanofibers. Interestingly, the formation of nanofibers is seen to emerge from the outer boundary of the spherical structures. Some of the nanofibers curl up at the tip and later result in the formation of hollow nanospheres with thick boundaries. The presence of β‐turn‐like structures with hydrogen bonding is observed using FT‐IR studies. The presence of hydrogen bonding is also demonstrated by using NMR studies.https://doi.org/10.1002/open.201800258electron microscopynanofibersnanospherespeptidesself-assembly |
| spellingShingle | Malapaka Venkata Vardhishna Gannoju Srinivasulu Adicherl Harikrishna Suman Siddharth Thakur Bhaswati Chatterjee Simultaneous Occurrence of Nanospheres and Nanofibers Self‐Assembled from Achiral Tripeptides ChemistryOpen electron microscopy nanofibers nanospheres peptides self-assembly |
| title | Simultaneous Occurrence of Nanospheres and Nanofibers Self‐Assembled from Achiral Tripeptides |
| title_full | Simultaneous Occurrence of Nanospheres and Nanofibers Self‐Assembled from Achiral Tripeptides |
| title_fullStr | Simultaneous Occurrence of Nanospheres and Nanofibers Self‐Assembled from Achiral Tripeptides |
| title_full_unstemmed | Simultaneous Occurrence of Nanospheres and Nanofibers Self‐Assembled from Achiral Tripeptides |
| title_short | Simultaneous Occurrence of Nanospheres and Nanofibers Self‐Assembled from Achiral Tripeptides |
| title_sort | simultaneous occurrence of nanospheres and nanofibers self assembled from achiral tripeptides |
| topic | electron microscopy nanofibers nanospheres peptides self-assembly |
| url | https://doi.org/10.1002/open.201800258 |
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