Succinate at the Crossroad of Metabolism and Angiogenesis: Roles of SDH, HIF1α and SUCNR1
Angiogenesis is an essential process by which new blood vessels develop from existing ones. While adequate angiogenesis is a physiological process during, for example, tissue repair, insufficient and excessive angiogenesis stands on the pathological side. Fine balance between pro- and anti-angiogeni...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/12/3089 |
| _version_ | 1827641709383647232 |
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| author | Reham Atallah Andrea Olschewski Akos Heinemann |
| author_facet | Reham Atallah Andrea Olschewski Akos Heinemann |
| author_sort | Reham Atallah |
| collection | DOAJ |
| description | Angiogenesis is an essential process by which new blood vessels develop from existing ones. While adequate angiogenesis is a physiological process during, for example, tissue repair, insufficient and excessive angiogenesis stands on the pathological side. Fine balance between pro- and anti-angiogenic factors in the tissue environment regulates angiogenesis. Identification of these factors and how they function is a pressing topic to develop angiogenesis-targeted therapeutics. During the last decade, exciting data highlighted non-metabolic functions of intermediates of the mitochondrial Krebs cycle including succinate. Among these functions is the contribution of succinate to angiogenesis in various contexts and through different mechanisms. As the concept of targeting metabolism to treat a wide range of diseases is rising, in this review we summarize the mechanisms by which succinate regulates angiogenesis in normal and pathological settings. Gaining a comprehensive insight into how this metabolite functions as an angiogenic signal will provide a useful approach to understand diseases with aberrant or excessive angiogenic background, and may provide strategies to tackle them. |
| first_indexed | 2024-03-09T17:18:36Z |
| format | Article |
| id | doaj.art-ca467c942e0f4a8389cc47e024a36b75 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:18:36Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-ca467c942e0f4a8389cc47e024a36b752023-11-24T13:26:36ZengMDPI AGBiomedicines2227-90592022-12-011012308910.3390/biomedicines10123089Succinate at the Crossroad of Metabolism and Angiogenesis: Roles of SDH, HIF1α and SUCNR1Reham Atallah0Andrea Olschewski1Akos Heinemann2Otto-Loewi Research Center for Vascular Biology, Immunology and Inflammation, Division of Pharmacology, Medical University of Graz, 8010 Graz, AustriaLudwig Boltzmann Institute for Lung Vascular Research, 8010 Graz, AustriaOtto-Loewi Research Center for Vascular Biology, Immunology and Inflammation, Division of Pharmacology, Medical University of Graz, 8010 Graz, AustriaAngiogenesis is an essential process by which new blood vessels develop from existing ones. While adequate angiogenesis is a physiological process during, for example, tissue repair, insufficient and excessive angiogenesis stands on the pathological side. Fine balance between pro- and anti-angiogenic factors in the tissue environment regulates angiogenesis. Identification of these factors and how they function is a pressing topic to develop angiogenesis-targeted therapeutics. During the last decade, exciting data highlighted non-metabolic functions of intermediates of the mitochondrial Krebs cycle including succinate. Among these functions is the contribution of succinate to angiogenesis in various contexts and through different mechanisms. As the concept of targeting metabolism to treat a wide range of diseases is rising, in this review we summarize the mechanisms by which succinate regulates angiogenesis in normal and pathological settings. Gaining a comprehensive insight into how this metabolite functions as an angiogenic signal will provide a useful approach to understand diseases with aberrant or excessive angiogenic background, and may provide strategies to tackle them.https://www.mdpi.com/2227-9059/10/12/3089succinatesuccinate dehydrogenase (SDH)succinate receptor-1 (SUCNR1)hypoxia-inducible factor 1-alpha (HIF1α)angiogenesis |
| spellingShingle | Reham Atallah Andrea Olschewski Akos Heinemann Succinate at the Crossroad of Metabolism and Angiogenesis: Roles of SDH, HIF1α and SUCNR1 Biomedicines succinate succinate dehydrogenase (SDH) succinate receptor-1 (SUCNR1) hypoxia-inducible factor 1-alpha (HIF1α) angiogenesis |
| title | Succinate at the Crossroad of Metabolism and Angiogenesis: Roles of SDH, HIF1α and SUCNR1 |
| title_full | Succinate at the Crossroad of Metabolism and Angiogenesis: Roles of SDH, HIF1α and SUCNR1 |
| title_fullStr | Succinate at the Crossroad of Metabolism and Angiogenesis: Roles of SDH, HIF1α and SUCNR1 |
| title_full_unstemmed | Succinate at the Crossroad of Metabolism and Angiogenesis: Roles of SDH, HIF1α and SUCNR1 |
| title_short | Succinate at the Crossroad of Metabolism and Angiogenesis: Roles of SDH, HIF1α and SUCNR1 |
| title_sort | succinate at the crossroad of metabolism and angiogenesis roles of sdh hif1α and sucnr1 |
| topic | succinate succinate dehydrogenase (SDH) succinate receptor-1 (SUCNR1) hypoxia-inducible factor 1-alpha (HIF1α) angiogenesis |
| url | https://www.mdpi.com/2227-9059/10/12/3089 |
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