Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders
Natural compounds such as herbal medicines and/or phyto-compounds from foods, have frequently been used to exert synergistic therapeutic effects with anti-brain disorder drugs, supplement the effects of nutrients, and boost the immune system. However, co-administration of natural compounds with the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-02-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/4/1809 |
| _version_ | 1797396891881701376 |
|---|---|
| author | Bikram Khadka Jae-Young Lee Eui Kyun Park Ki-Taek Kim Jong-Sup Bae |
| author_facet | Bikram Khadka Jae-Young Lee Eui Kyun Park Ki-Taek Kim Jong-Sup Bae |
| author_sort | Bikram Khadka |
| collection | DOAJ |
| description | Natural compounds such as herbal medicines and/or phyto-compounds from foods, have frequently been used to exert synergistic therapeutic effects with anti-brain disorder drugs, supplement the effects of nutrients, and boost the immune system. However, co-administration of natural compounds with the drugs can cause synergistic toxicity or impeditive drug interactions due to changes in pharmacokinetic properties (e.g., absorption, metabolism, and excretion) and various drug transporters, particularly brain transporters. In this review, natural compound–drug interactions (NDIs), which can occur during the treatment of brain disorders, are emphasized from the perspective of pharmacokinetics and cellular transport. In addition, the challenges emanating from NDIs and recent approaches are discussed. |
| first_indexed | 2024-03-09T00:58:02Z |
| format | Article |
| id | doaj.art-ca472bf1598d4b1db813ebcf2f1a6582 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T00:58:02Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ca472bf1598d4b1db813ebcf2f1a65822023-12-11T16:48:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01224180910.3390/ijms22041809Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain DisordersBikram Khadka0Jae-Young Lee1Eui Kyun Park2Ki-Taek Kim3Jong-Sup Bae4Department of Biomedicine, Health & Life Convergence Sciences, BK21 Four, Mokpo National University, Muan-gun, Jeonnam 58554, KoreaCollege of Pharmacy, Chungnam National University, Daejeon 34134, KoreaDepartment of Pathology and Regenerative Medicine, School of Dentistry, Kyungpook National University, Daegu 41940, KoreaDepartment of Biomedicine, Health & Life Convergence Sciences, BK21 Four, Mokpo National University, Muan-gun, Jeonnam 58554, KoreaCollege of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, KoreaNatural compounds such as herbal medicines and/or phyto-compounds from foods, have frequently been used to exert synergistic therapeutic effects with anti-brain disorder drugs, supplement the effects of nutrients, and boost the immune system. However, co-administration of natural compounds with the drugs can cause synergistic toxicity or impeditive drug interactions due to changes in pharmacokinetic properties (e.g., absorption, metabolism, and excretion) and various drug transporters, particularly brain transporters. In this review, natural compound–drug interactions (NDIs), which can occur during the treatment of brain disorders, are emphasized from the perspective of pharmacokinetics and cellular transport. In addition, the challenges emanating from NDIs and recent approaches are discussed.https://www.mdpi.com/1422-0067/22/4/1809natural compound–drug interactions (NDIs)pharmacokineticsdrug transportersblood–brain barrier (BBB) and blood–cerebrospinal fluid barrier (BCSFB)brain disorders |
| spellingShingle | Bikram Khadka Jae-Young Lee Eui Kyun Park Ki-Taek Kim Jong-Sup Bae Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders International Journal of Molecular Sciences natural compound–drug interactions (NDIs) pharmacokinetics drug transporters blood–brain barrier (BBB) and blood–cerebrospinal fluid barrier (BCSFB) brain disorders |
| title | Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders |
| title_full | Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders |
| title_fullStr | Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders |
| title_full_unstemmed | Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders |
| title_short | Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders |
| title_sort | impacts of drug interactions on pharmacokinetics and the brain transporters a recent review of natural compound drug interactions in brain disorders |
| topic | natural compound–drug interactions (NDIs) pharmacokinetics drug transporters blood–brain barrier (BBB) and blood–cerebrospinal fluid barrier (BCSFB) brain disorders |
| url | https://www.mdpi.com/1422-0067/22/4/1809 |
| work_keys_str_mv | AT bikramkhadka impactsofdruginteractionsonpharmacokineticsandthebraintransportersarecentreviewofnaturalcompounddruginteractionsinbraindisorders AT jaeyounglee impactsofdruginteractionsonpharmacokineticsandthebraintransportersarecentreviewofnaturalcompounddruginteractionsinbraindisorders AT euikyunpark impactsofdruginteractionsonpharmacokineticsandthebraintransportersarecentreviewofnaturalcompounddruginteractionsinbraindisorders AT kitaekkim impactsofdruginteractionsonpharmacokineticsandthebraintransportersarecentreviewofnaturalcompounddruginteractionsinbraindisorders AT jongsupbae impactsofdruginteractionsonpharmacokineticsandthebraintransportersarecentreviewofnaturalcompounddruginteractionsinbraindisorders |