Leukocyte Trafficking and Regulation of Murine Hematopoietic Stem Cells and Their Niches
Hematopoietic stem cells (HSC) are the most powerful type of adult stem cell found in the body. Hematopoietic stem cells are multipotent and capable of giving rise to all other types of hematopoietic cells found in the organism. A single HSC is capable of regenerating a functional hematopoietic syst...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00387/full |
| _version_ | 1819295126568042496 |
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| author | Daniel Lucas Daniel Lucas |
| author_facet | Daniel Lucas Daniel Lucas |
| author_sort | Daniel Lucas |
| collection | DOAJ |
| description | Hematopoietic stem cells (HSC) are the most powerful type of adult stem cell found in the body. Hematopoietic stem cells are multipotent and capable of giving rise to all other types of hematopoietic cells found in the organism. A single HSC is capable of regenerating a functional hematopoietic system when transplanted into a recipient. Hematopoietic stem cells reside in the bone marrow in specific multicellular structures called niches. These niches are indispensable for maintaining and regulating HSC numbers and function. It has become increasingly clearer that HSC and their niches can also be regulated by migrating leukocytes. Here we will discuss the composition of murine bone marrow niches and how HSC and their niches are regulated by different types of leukocytes that traffic between the periphery and the niche. Unless otherwise indicated all the studies discussed below were performed in mouse models. |
| first_indexed | 2024-12-24T04:37:16Z |
| format | Article |
| id | doaj.art-ca48157b7ad941aaa043c6d58d2475ff |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-24T04:37:16Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ca48157b7ad941aaa043c6d58d2475ff2022-12-21T17:15:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-03-011010.3389/fimmu.2019.00387435553Leukocyte Trafficking and Regulation of Murine Hematopoietic Stem Cells and Their NichesDaniel Lucas0Daniel Lucas1Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United StatesDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United StatesHematopoietic stem cells (HSC) are the most powerful type of adult stem cell found in the body. Hematopoietic stem cells are multipotent and capable of giving rise to all other types of hematopoietic cells found in the organism. A single HSC is capable of regenerating a functional hematopoietic system when transplanted into a recipient. Hematopoietic stem cells reside in the bone marrow in specific multicellular structures called niches. These niches are indispensable for maintaining and regulating HSC numbers and function. It has become increasingly clearer that HSC and their niches can also be regulated by migrating leukocytes. Here we will discuss the composition of murine bone marrow niches and how HSC and their niches are regulated by different types of leukocytes that traffic between the periphery and the niche. Unless otherwise indicated all the studies discussed below were performed in mouse models.https://www.frontiersin.org/article/10.3389/fimmu.2019.00387/fullhematopoietic stem cellnichesleukocyte traffickingneutrophilsTregs |
| spellingShingle | Daniel Lucas Daniel Lucas Leukocyte Trafficking and Regulation of Murine Hematopoietic Stem Cells and Their Niches Frontiers in Immunology hematopoietic stem cell niches leukocyte trafficking neutrophils Tregs |
| title | Leukocyte Trafficking and Regulation of Murine Hematopoietic Stem Cells and Their Niches |
| title_full | Leukocyte Trafficking and Regulation of Murine Hematopoietic Stem Cells and Their Niches |
| title_fullStr | Leukocyte Trafficking and Regulation of Murine Hematopoietic Stem Cells and Their Niches |
| title_full_unstemmed | Leukocyte Trafficking and Regulation of Murine Hematopoietic Stem Cells and Their Niches |
| title_short | Leukocyte Trafficking and Regulation of Murine Hematopoietic Stem Cells and Their Niches |
| title_sort | leukocyte trafficking and regulation of murine hematopoietic stem cells and their niches |
| topic | hematopoietic stem cell niches leukocyte trafficking neutrophils Tregs |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00387/full |
| work_keys_str_mv | AT daniellucas leukocytetraffickingandregulationofmurinehematopoieticstemcellsandtheirniches AT daniellucas leukocytetraffickingandregulationofmurinehematopoieticstemcellsandtheirniches |