Nifedipine Exacerbates Lipogenesis in the Kidney via KIM-1, CD36, and SREBP Upregulation: Implications from an Animal Model for Human Study

Nifedipine Exacerbates Lipogenesis in the Kidney via KIM-1, CD36, and SREBP Upregulation: Implications from an Animal Model for Human Study

Dysregulation of fatty acid oxidation and accumulation of fatty acids can cause kidney injury. Nifedipine modulates lipogenesis-related transcriptional factor SREBP-1/2 in proximal tubular cells by inhibiting the Adenosine 5‘-monophosphate (AMP)-activated protein kinase (AMPK) pathway in vitro. Howe...

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Bibliographic Details
Main Authors:	Yen-Chung Lin, Jhih-Cheng Wang, Mai-Szu Wu, Yuh-Feng Lin, Chang-Rong Chen, Chang-Yu Chen, Kuan-Chou Chen, Chiung-Chi Peng
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Series:	International Journal of Molecular Sciences
Subjects:	chronic kidney disease calcium channel blocker lipid SREBP CD36
Online Access:	https://www.mdpi.com/1422-0067/21/12/4359

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