Simultaneous Electrochemical Determination of Chlorzoxazone and Diclofenac on an Efficient Modified Glassy Carbon Electrode by Lanthanum Oxide@ Copper(I) Sulfide Composite
This study synthesized a La2O3@snowflake-like Cu2S composite to fabricate an electrochemical sensor for sensitively simultaneous detection of diclofenac and chlorzoxazone exploiting an easy hydrothermal approach, followed by analysis with XRD, FE-SEM, and EDX methods. According to voltammetric studi...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.889590/full |
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| author | Bahar Baniahmad Hadi Hassani Nadiki Shohreh Jahani Najmeh Nezamabadi-Pour Ali Toolabi Mohammad Mehdi Foroughi |
| author_facet | Bahar Baniahmad Hadi Hassani Nadiki Shohreh Jahani Najmeh Nezamabadi-Pour Ali Toolabi Mohammad Mehdi Foroughi |
| author_sort | Bahar Baniahmad |
| collection | DOAJ |
| description | This study synthesized a La2O3@snowflake-like Cu2S composite to fabricate an electrochemical sensor for sensitively simultaneous detection of diclofenac and chlorzoxazone exploiting an easy hydrothermal approach, followed by analysis with XRD, FE-SEM, and EDX methods. According to voltammetric studies, the electrocatalytic diclofenac and chlorzoxazone oxidations on the electrode modified with La2O3@SF-L Cu2S composites were increased, with greater oxidation currents, as well as the oxidation potential was significantly decreased due to synergetic impact of La2O3@SF-L Cu2S composites when compared with the pure SF-L Cu2S NS-modified electrode. The differential pulse voltammetry findings showed wide straight lines (0.01–900.0 μM) for La2O3 NP@SF-L Cu2S NS-modified electrode with a limit of detection (LOD) of 1.7 and 2.3 nM for the detection of diclofenac and chlorzoxazone, respectively. In addition, the limit of quantification was calculated to be 5.7 and 7.6 nM for diclofenac and chlorzoxazone, respectively. The diffusion coefficient was calculated to be 1.16 × 10−5and 8.4 × 10−6 cm2/s for diclofenac and chlorzoxazone oxidation on the modified electrode, respectively. Our proposed electrode was examined for applicability by detecting diclofenac and chlorzoxazone in real specimens. |
| first_indexed | 2024-12-12T03:44:30Z |
| format | Article |
| id | doaj.art-ca4a8518818b4551ab693b819893d24e |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-12T03:44:30Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-ca4a8518818b4551ab693b819893d24e2022-12-22T00:39:36ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-06-011010.3389/fchem.2022.889590889590Simultaneous Electrochemical Determination of Chlorzoxazone and Diclofenac on an Efficient Modified Glassy Carbon Electrode by Lanthanum Oxide@ Copper(I) Sulfide CompositeBahar Baniahmad0Hadi Hassani Nadiki1Shohreh Jahani2Najmeh Nezamabadi-Pour3Ali Toolabi4Mohammad Mehdi Foroughi5Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Chemistry, Kerman Branch, Islamic Azad University, Kerman, IranNoncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, IranBam University of Medical Sciences, Bam, IranDepartment of Environmental Health Engineering, School of Public Health, Bam University of Medical Sciences, Bam, IranDepartment of Chemistry, Kerman Branch, Islamic Azad University, Kerman, IranThis study synthesized a La2O3@snowflake-like Cu2S composite to fabricate an electrochemical sensor for sensitively simultaneous detection of diclofenac and chlorzoxazone exploiting an easy hydrothermal approach, followed by analysis with XRD, FE-SEM, and EDX methods. According to voltammetric studies, the electrocatalytic diclofenac and chlorzoxazone oxidations on the electrode modified with La2O3@SF-L Cu2S composites were increased, with greater oxidation currents, as well as the oxidation potential was significantly decreased due to synergetic impact of La2O3@SF-L Cu2S composites when compared with the pure SF-L Cu2S NS-modified electrode. The differential pulse voltammetry findings showed wide straight lines (0.01–900.0 μM) for La2O3 NP@SF-L Cu2S NS-modified electrode with a limit of detection (LOD) of 1.7 and 2.3 nM for the detection of diclofenac and chlorzoxazone, respectively. In addition, the limit of quantification was calculated to be 5.7 and 7.6 nM for diclofenac and chlorzoxazone, respectively. The diffusion coefficient was calculated to be 1.16 × 10−5and 8.4 × 10−6 cm2/s for diclofenac and chlorzoxazone oxidation on the modified electrode, respectively. Our proposed electrode was examined for applicability by detecting diclofenac and chlorzoxazone in real specimens.https://www.frontiersin.org/articles/10.3389/fchem.2022.889590/fulldiclofenacchlorzoxazonenanocompositevoltammetrymodified electrode |
| spellingShingle | Bahar Baniahmad Hadi Hassani Nadiki Shohreh Jahani Najmeh Nezamabadi-Pour Ali Toolabi Mohammad Mehdi Foroughi Simultaneous Electrochemical Determination of Chlorzoxazone and Diclofenac on an Efficient Modified Glassy Carbon Electrode by Lanthanum Oxide@ Copper(I) Sulfide Composite Frontiers in Chemistry diclofenac chlorzoxazone nanocomposite voltammetry modified electrode |
| title | Simultaneous Electrochemical Determination of Chlorzoxazone and Diclofenac on an Efficient Modified Glassy Carbon Electrode by Lanthanum Oxide@ Copper(I) Sulfide Composite |
| title_full | Simultaneous Electrochemical Determination of Chlorzoxazone and Diclofenac on an Efficient Modified Glassy Carbon Electrode by Lanthanum Oxide@ Copper(I) Sulfide Composite |
| title_fullStr | Simultaneous Electrochemical Determination of Chlorzoxazone and Diclofenac on an Efficient Modified Glassy Carbon Electrode by Lanthanum Oxide@ Copper(I) Sulfide Composite |
| title_full_unstemmed | Simultaneous Electrochemical Determination of Chlorzoxazone and Diclofenac on an Efficient Modified Glassy Carbon Electrode by Lanthanum Oxide@ Copper(I) Sulfide Composite |
| title_short | Simultaneous Electrochemical Determination of Chlorzoxazone and Diclofenac on an Efficient Modified Glassy Carbon Electrode by Lanthanum Oxide@ Copper(I) Sulfide Composite |
| title_sort | simultaneous electrochemical determination of chlorzoxazone and diclofenac on an efficient modified glassy carbon electrode by lanthanum oxide copper i sulfide composite |
| topic | diclofenac chlorzoxazone nanocomposite voltammetry modified electrode |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.889590/full |
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