Relevance of epithelial-to-pericyte transition in cancer
The relevance of epithelial-to-mesenchymal transition (EMT) in cancer is still under debate. Recently, we reported that EMT bestows key pericyte properties on cancer cells and may thus represent epithelial-to-pericyte transition (EPT). Carcinoma cells undergo EPT to stabilize blood vessels and fuel...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2016.1260672 |
| _version_ | 1797677239241801728 |
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| author | Anitha K. Shenoy Jianrong Lu |
| author_facet | Anitha K. Shenoy Jianrong Lu |
| author_sort | Anitha K. Shenoy |
| collection | DOAJ |
| description | The relevance of epithelial-to-mesenchymal transition (EMT) in cancer is still under debate. Recently, we reported that EMT bestows key pericyte properties on cancer cells and may thus represent epithelial-to-pericyte transition (EPT). Carcinoma cells undergo EPT to stabilize blood vessels and fuel primary tumor growth. Association of EPT cancer cells with vascular niches may also promote resistance to therapy. |
| first_indexed | 2024-03-11T22:42:10Z |
| format | Article |
| id | doaj.art-ca4b07683d5d445591838fcae7b5d903 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:42:10Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-ca4b07683d5d445591838fcae7b5d9032023-09-22T09:10:57ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562017-01-014110.1080/23723556.2016.12606721260672Relevance of epithelial-to-pericyte transition in cancerAnitha K. Shenoy0Jianrong Lu1California Health Sciences UniversityUniversity of Florida College of MedicineThe relevance of epithelial-to-mesenchymal transition (EMT) in cancer is still under debate. Recently, we reported that EMT bestows key pericyte properties on cancer cells and may thus represent epithelial-to-pericyte transition (EPT). Carcinoma cells undergo EPT to stabilize blood vessels and fuel primary tumor growth. Association of EPT cancer cells with vascular niches may also promote resistance to therapy.http://dx.doi.org/10.1080/23723556.2016.1260672blood vesselemtendothelial celleptmetastasisn-cadherinpdgfr-βpericyte |
| spellingShingle | Anitha K. Shenoy Jianrong Lu Relevance of epithelial-to-pericyte transition in cancer Molecular & Cellular Oncology blood vessel emt endothelial cell ept metastasis n-cadherin pdgfr-β pericyte |
| title | Relevance of epithelial-to-pericyte transition in cancer |
| title_full | Relevance of epithelial-to-pericyte transition in cancer |
| title_fullStr | Relevance of epithelial-to-pericyte transition in cancer |
| title_full_unstemmed | Relevance of epithelial-to-pericyte transition in cancer |
| title_short | Relevance of epithelial-to-pericyte transition in cancer |
| title_sort | relevance of epithelial to pericyte transition in cancer |
| topic | blood vessel emt endothelial cell ept metastasis n-cadherin pdgfr-β pericyte |
| url | http://dx.doi.org/10.1080/23723556.2016.1260672 |
| work_keys_str_mv | AT anithakshenoy relevanceofepithelialtopericytetransitionincancer AT jianronglu relevanceofepithelialtopericytetransitionincancer |