Inhibition of histone deacetylases facilitates extinction and attenuates reinstatement of nicotine self-administration in rats.

Inhibition of histone deacetylases facilitates extinction and attenuates reinstatement of nicotine self-administration in rats.

Chromatin remodelling is integral to the formation of long-term memories. Recent evidence suggests that histone modification may play a role in the persistence of memories associated with drug use. The present series of experiments aimed to examine the effect of histone deacetylase (HDAC) inhibition...

Full description

Bibliographic Details
Main Authors: Matthew R Castino, Jennifer L Cornish, Kelly J Clemens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4399837?pdf=render

Similar Items

Similar Items