Antioxidant capacity and combinatorial antimicrobial effects of Nardostachys jatamansi essential oil with conventional antibiotics against some drug resistant bacteria
The antibacterial and antioxidant properties of essential oils (EOs) have long been recognized. The present study was conducted to investigate the antioxidant capability of Nardostachys jatamansi essential oil and to see if it has a synergistic antimicrobial effect with antibiotics against two Gram...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Current Research in Biotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259026282200051X |
| _version_ | 1797797159493435392 |
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| author | Aasiya Majeed Sanjay Guleria Neha Sharma Khalid Hussain Salaria Faiqa Aiman Bikarma Singh Vijai Kumar Gupta |
| author_facet | Aasiya Majeed Sanjay Guleria Neha Sharma Khalid Hussain Salaria Faiqa Aiman Bikarma Singh Vijai Kumar Gupta |
| author_sort | Aasiya Majeed |
| collection | DOAJ |
| description | The antibacterial and antioxidant properties of essential oils (EOs) have long been recognized. The present study was conducted to investigate the antioxidant capability of Nardostachys jatamansi essential oil and to see if it has a synergistic antimicrobial effect with antibiotics against two Gram negative (Klebsiella pneumoniae and Escherichia coli) and three Gram positive (Bacillus subtilis, Micrococcus luteus and Staphylococcus aureus) bacterial strains. Guaia-6,9-diene (11.96 %), calarene (10.44 %), jatamansone (8.11 %), α-gurjunene (7.42 %), valencene (6.46 %), α-maaliene (5.24 %), sprojatamol (5.06 %), and caratol (5.06 %) were found to be the primary components of N. jatamansi EO. According to antioxidant studies, N. jatamansi EO has moderate DPPH radical scavenging activity, reducing power, and ferric reducing antioxidant power. Similarly, N. jatamansi EO also showed significant antibacterial activity, with inhibition zones, MIC, and MBC values ranging from 10.5 ± 0.5 to 14.0 ± 0.4 mm, 1.5 to 3.1 mg/mL, and 1.8 to 3.5 mg/mL respectively. The results of N. jatamansi EO interactions with conventional antibiotics revealed that amoxicillin, erythromycin, chloramphenicol, and ampicillin MICs were reduced by 5 to 10 fold, 4 to 9.09 fold, 4 to 10.5 fold, and 4 to 8.0 fold, respectively. The findings of this study are noteworthy because no previous reports of N. jatamansi EO's synergistic interaction with conventional antibiotics have been published, and therefore may constitute an important strategy for addressing problem of drug resistant bacteria. |
| first_indexed | 2024-03-13T03:43:58Z |
| format | Article |
| id | doaj.art-ca5064f8515a42d3aed7aa7b03417639 |
| institution | Directory Open Access Journal |
| issn | 2590-2628 |
| language | English |
| last_indexed | 2024-03-13T03:43:58Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Biotechnology |
| spelling | doaj.art-ca5064f8515a42d3aed7aa7b034176392023-06-23T04:44:00ZengElsevierCurrent Research in Biotechnology2590-26282023-01-015100118Antioxidant capacity and combinatorial antimicrobial effects of Nardostachys jatamansi essential oil with conventional antibiotics against some drug resistant bacteriaAasiya Majeed0Sanjay Guleria1Neha Sharma2Khalid Hussain Salaria3Faiqa Aiman4Bikarma Singh5Vijai Kumar Gupta6Natural Product-cum-Nano Lab, Division of Biochemistry, Faculty of Basic Sciences,Sher-e- Kashmir University of Agricultural Sciences and Technology of Jammu, Main Campus Chatha, Jammu- 180009, Jammu and Kashmir, IndiaNatural Product-cum-Nano Lab, Division of Biochemistry, Faculty of Basic Sciences,Sher-e- Kashmir University of Agricultural Sciences and Technology of Jammu, Main Campus Chatha, Jammu- 180009, Jammu and Kashmir, India; Corresponding author.Natural Product-cum-Nano Lab, Division of Biochemistry, Faculty of Basic Sciences,Sher-e- Kashmir University of Agricultural Sciences and Technology of Jammu, Main Campus Chatha, Jammu- 180009, Jammu and Kashmir, IndiaNatural Product-cum-Nano Lab, Division of Biochemistry, Faculty of Basic Sciences,Sher-e- Kashmir University of Agricultural Sciences and Technology of Jammu, Main Campus Chatha, Jammu- 180009, Jammu and Kashmir, IndiaNatural Product-cum-Nano Lab, Division of Biochemistry, Faculty of Basic Sciences,Sher-e- Kashmir University of Agricultural Sciences and Technology of Jammu, Main Campus Chatha, Jammu- 180009, Jammu and Kashmir, IndiaBotanic Garden Division, CSIR-National Botanical Research Institute, Lucknow 226001, Uttar Pradesh, IndiaBiorefining and Advanced Materials Research Center, SRUC, Kings Building, West Mains Road, Edinburgh EH9 3JG, UKThe antibacterial and antioxidant properties of essential oils (EOs) have long been recognized. The present study was conducted to investigate the antioxidant capability of Nardostachys jatamansi essential oil and to see if it has a synergistic antimicrobial effect with antibiotics against two Gram negative (Klebsiella pneumoniae and Escherichia coli) and three Gram positive (Bacillus subtilis, Micrococcus luteus and Staphylococcus aureus) bacterial strains. Guaia-6,9-diene (11.96 %), calarene (10.44 %), jatamansone (8.11 %), α-gurjunene (7.42 %), valencene (6.46 %), α-maaliene (5.24 %), sprojatamol (5.06 %), and caratol (5.06 %) were found to be the primary components of N. jatamansi EO. According to antioxidant studies, N. jatamansi EO has moderate DPPH radical scavenging activity, reducing power, and ferric reducing antioxidant power. Similarly, N. jatamansi EO also showed significant antibacterial activity, with inhibition zones, MIC, and MBC values ranging from 10.5 ± 0.5 to 14.0 ± 0.4 mm, 1.5 to 3.1 mg/mL, and 1.8 to 3.5 mg/mL respectively. The results of N. jatamansi EO interactions with conventional antibiotics revealed that amoxicillin, erythromycin, chloramphenicol, and ampicillin MICs were reduced by 5 to 10 fold, 4 to 9.09 fold, 4 to 10.5 fold, and 4 to 8.0 fold, respectively. The findings of this study are noteworthy because no previous reports of N. jatamansi EO's synergistic interaction with conventional antibiotics have been published, and therefore may constitute an important strategy for addressing problem of drug resistant bacteria.http://www.sciencedirect.com/science/article/pii/S259026282200051XNardostachys jatamansiAntibioticsSynergistic antimicrobial activityAntioxidant activity |
| spellingShingle | Aasiya Majeed Sanjay Guleria Neha Sharma Khalid Hussain Salaria Faiqa Aiman Bikarma Singh Vijai Kumar Gupta Antioxidant capacity and combinatorial antimicrobial effects of Nardostachys jatamansi essential oil with conventional antibiotics against some drug resistant bacteria Current Research in Biotechnology Nardostachys jatamansi Antibiotics Synergistic antimicrobial activity Antioxidant activity |
| title | Antioxidant capacity and combinatorial antimicrobial effects of Nardostachys jatamansi essential oil with conventional antibiotics against some drug resistant bacteria |
| title_full | Antioxidant capacity and combinatorial antimicrobial effects of Nardostachys jatamansi essential oil with conventional antibiotics against some drug resistant bacteria |
| title_fullStr | Antioxidant capacity and combinatorial antimicrobial effects of Nardostachys jatamansi essential oil with conventional antibiotics against some drug resistant bacteria |
| title_full_unstemmed | Antioxidant capacity and combinatorial antimicrobial effects of Nardostachys jatamansi essential oil with conventional antibiotics against some drug resistant bacteria |
| title_short | Antioxidant capacity and combinatorial antimicrobial effects of Nardostachys jatamansi essential oil with conventional antibiotics against some drug resistant bacteria |
| title_sort | antioxidant capacity and combinatorial antimicrobial effects of nardostachys jatamansi essential oil with conventional antibiotics against some drug resistant bacteria |
| topic | Nardostachys jatamansi Antibiotics Synergistic antimicrobial activity Antioxidant activity |
| url | http://www.sciencedirect.com/science/article/pii/S259026282200051X |
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