Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 1: Roles of VSOR/VRAC in Cell Volume Regulation, Release of Double-Edged Signals and Apoptotic/Necrotic Cell Death
Cell volume regulation (CVR) is essential for survival and functions of animal cells. Actually, normotonic cell shrinkage and swelling are coupled to apoptotic and necrotic cell death and thus called the apoptotic volume decrease (AVD) and the necrotic volume increase (NVI), respectively. A number o...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-01-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2020.614040/full |
| _version_ | 1818573422903427072 |
|---|---|
| author | Yasunobu Okada Yasunobu Okada Yasunobu Okada Ravshan Z. Sabirov Kaori Sato-Numata Kaori Sato-Numata Tomohiro Numata |
| author_facet | Yasunobu Okada Yasunobu Okada Yasunobu Okada Ravshan Z. Sabirov Kaori Sato-Numata Kaori Sato-Numata Tomohiro Numata |
| author_sort | Yasunobu Okada |
| collection | DOAJ |
| description | Cell volume regulation (CVR) is essential for survival and functions of animal cells. Actually, normotonic cell shrinkage and swelling are coupled to apoptotic and necrotic cell death and thus called the apoptotic volume decrease (AVD) and the necrotic volume increase (NVI), respectively. A number of ubiquitously expressed anion and cation channels are involved not only in CVD but also in cell death induction. This series of review articles address the question how cell death is induced or protected with using ubiquitously expressed ion channels such as swelling-activated anion channels, acid-activated anion channels and several types of TRP cation channels including TRPM2 and TRPM7. The Part 1 focuses on the roles of the volume-sensitive outwardly rectifying anion channels (VSOR), also called the volume-regulated anion channel (VRAC), which is activated by cell swelling or reactive oxygen species (ROS) in a manner dependent on intracellular ATP. First we describe phenotypical properties, the molecular identity, and physical pore dimensions of VSOR/VRAC. Second, we highlight the roles of VSOR/VRAC in the release of organic signaling molecules, such as glutamate, glutathione, ATP and cGAMP, that play roles as double-edged swords in cell survival. Third, we discuss how VSOR/VRAC is involved in CVR and cell volume dysregulation as well as in the induction of or protection from apoptosis, necrosis and regulated necrosis under pathophysiological conditions. |
| first_indexed | 2024-12-15T00:11:06Z |
| format | Article |
| id | doaj.art-ca529f3f841c435197acaaa53dd0fd54 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-15T00:11:06Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-ca529f3f841c435197acaaa53dd0fd542022-12-21T22:42:34ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-01-01810.3389/fcell.2020.614040614040Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 1: Roles of VSOR/VRAC in Cell Volume Regulation, Release of Double-Edged Signals and Apoptotic/Necrotic Cell DeathYasunobu Okada0Yasunobu Okada1Yasunobu Okada2Ravshan Z. Sabirov3Kaori Sato-Numata4Kaori Sato-Numata5Tomohiro Numata6National Institute for Physiological Sciences, Okazaki, JapanDepartment of Physiology, School of Medicine, Aichi Medical University, Nagakute, JapanDepartment of Physiology, Kyoto Prefectural University of Medicine, Kyoto, JapanLaboratory of Molecular Physiology, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanJapan Society for the Promotion of Science, Tokyo, JapanDepartment of Physiology, School of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Physiology, School of Medicine, Fukuoka University, Fukuoka, JapanCell volume regulation (CVR) is essential for survival and functions of animal cells. Actually, normotonic cell shrinkage and swelling are coupled to apoptotic and necrotic cell death and thus called the apoptotic volume decrease (AVD) and the necrotic volume increase (NVI), respectively. A number of ubiquitously expressed anion and cation channels are involved not only in CVD but also in cell death induction. This series of review articles address the question how cell death is induced or protected with using ubiquitously expressed ion channels such as swelling-activated anion channels, acid-activated anion channels and several types of TRP cation channels including TRPM2 and TRPM7. The Part 1 focuses on the roles of the volume-sensitive outwardly rectifying anion channels (VSOR), also called the volume-regulated anion channel (VRAC), which is activated by cell swelling or reactive oxygen species (ROS) in a manner dependent on intracellular ATP. First we describe phenotypical properties, the molecular identity, and physical pore dimensions of VSOR/VRAC. Second, we highlight the roles of VSOR/VRAC in the release of organic signaling molecules, such as glutamate, glutathione, ATP and cGAMP, that play roles as double-edged swords in cell survival. Third, we discuss how VSOR/VRAC is involved in CVR and cell volume dysregulation as well as in the induction of or protection from apoptosis, necrosis and regulated necrosis under pathophysiological conditions.https://www.frontiersin.org/articles/10.3389/fcell.2020.614040/fullcell volume regulationapoptotic cell deathnecrotic cell deathVSOR/VRACglutamate releaseGSH release |
| spellingShingle | Yasunobu Okada Yasunobu Okada Yasunobu Okada Ravshan Z. Sabirov Kaori Sato-Numata Kaori Sato-Numata Tomohiro Numata Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 1: Roles of VSOR/VRAC in Cell Volume Regulation, Release of Double-Edged Signals and Apoptotic/Necrotic Cell Death Frontiers in Cell and Developmental Biology cell volume regulation apoptotic cell death necrotic cell death VSOR/VRAC glutamate release GSH release |
| title | Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 1: Roles of VSOR/VRAC in Cell Volume Regulation, Release of Double-Edged Signals and Apoptotic/Necrotic Cell Death |
| title_full | Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 1: Roles of VSOR/VRAC in Cell Volume Regulation, Release of Double-Edged Signals and Apoptotic/Necrotic Cell Death |
| title_fullStr | Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 1: Roles of VSOR/VRAC in Cell Volume Regulation, Release of Double-Edged Signals and Apoptotic/Necrotic Cell Death |
| title_full_unstemmed | Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 1: Roles of VSOR/VRAC in Cell Volume Regulation, Release of Double-Edged Signals and Apoptotic/Necrotic Cell Death |
| title_short | Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 1: Roles of VSOR/VRAC in Cell Volume Regulation, Release of Double-Edged Signals and Apoptotic/Necrotic Cell Death |
| title_sort | cell death induction and protection by activation of ubiquitously expressed anion cation channels part 1 roles of vsor vrac in cell volume regulation release of double edged signals and apoptotic necrotic cell death |
| topic | cell volume regulation apoptotic cell death necrotic cell death VSOR/VRAC glutamate release GSH release |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2020.614040/full |
| work_keys_str_mv | AT yasunobuokada celldeathinductionandprotectionbyactivationofubiquitouslyexpressedanioncationchannelspart1rolesofvsorvracincellvolumeregulationreleaseofdoubleedgedsignalsandapoptoticnecroticcelldeath AT yasunobuokada celldeathinductionandprotectionbyactivationofubiquitouslyexpressedanioncationchannelspart1rolesofvsorvracincellvolumeregulationreleaseofdoubleedgedsignalsandapoptoticnecroticcelldeath AT yasunobuokada celldeathinductionandprotectionbyactivationofubiquitouslyexpressedanioncationchannelspart1rolesofvsorvracincellvolumeregulationreleaseofdoubleedgedsignalsandapoptoticnecroticcelldeath AT ravshanzsabirov celldeathinductionandprotectionbyactivationofubiquitouslyexpressedanioncationchannelspart1rolesofvsorvracincellvolumeregulationreleaseofdoubleedgedsignalsandapoptoticnecroticcelldeath AT kaorisatonumata celldeathinductionandprotectionbyactivationofubiquitouslyexpressedanioncationchannelspart1rolesofvsorvracincellvolumeregulationreleaseofdoubleedgedsignalsandapoptoticnecroticcelldeath AT kaorisatonumata celldeathinductionandprotectionbyactivationofubiquitouslyexpressedanioncationchannelspart1rolesofvsorvracincellvolumeregulationreleaseofdoubleedgedsignalsandapoptoticnecroticcelldeath AT tomohironumata celldeathinductionandprotectionbyactivationofubiquitouslyexpressedanioncationchannelspart1rolesofvsorvracincellvolumeregulationreleaseofdoubleedgedsignalsandapoptoticnecroticcelldeath |