Necroptosis Blockade Potentiates the Neuroprotective Effect of Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy

Necroptosis Blockade Potentiates the Neuroprotective Effect of Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy

Neonatal encephalopathy (NE) caused by hypoxia-ischemia (HI) affects around 1 per 1000 term newborns and is the leading cause of acquired brain injury and neurodisability. Despite the use of hypothermia (HT) as a standard of care, the incidence of NE and its devastating outcomes remains a major issu...

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Bibliographic Details
Main Authors: Mathilde Chevin, Stéphane Chabrier, Marie-Julie Allard, Guillaume Sébire
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomedicines
Subjects:
HI
HT
necroptosis
Nec-1
MLKL
RIPK
Online Access:https://www.mdpi.com/2227-9059/10/11/2913

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