<i>Zingiber mioga</i> Extract Improves Moisturization and Depigmentation of Skin and Reduces Wrinkle Formation in UVB-Irradiated HRM-2 Hairless Mice
Here, we investigated the effects of <i>Zingiber mioga</i> extracts (FSH-ZM) on the moisturization and depigmentation of skin as well as wrinkle formation in UVB-irradiated HRM-2 hairless mice. The mice were divided into six groups as follows: normal control (NC), UVB-irradiated control...
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MDPI AG
2021-01-01
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| author | Soo-Jeung Park Minhee Lee Jeong-Moon Yun Dakyung Kim Jeonmin Lee Yoo-Hyun Lee |
| author_facet | Soo-Jeung Park Minhee Lee Jeong-Moon Yun Dakyung Kim Jeonmin Lee Yoo-Hyun Lee |
| author_sort | Soo-Jeung Park |
| collection | DOAJ |
| description | Here, we investigated the effects of <i>Zingiber mioga</i> extracts (FSH-ZM) on the moisturization and depigmentation of skin as well as wrinkle formation in UVB-irradiated HRM-2 hairless mice. The mice were divided into six groups as follows: normal control (NC), UVB-irradiated control (C), positive control 1 (PC1, L-ascorbic acid 200 mg/kg b.w.), positive control 2 (PC2, Arbutin 200 mg/kg b.w.), Z100 (FSH-ZM 100 mg/kg b.w.), and Z200 (FSH-ZM 200 mg/kg b.w.). The experiment spanned a period of 6 weeks. We found that FSH-ZM led to an increase in the expression of hyaluronan synthase 2, fibrillin-1, and elastin mRNAs, and showed improved skin hydration in HRM-2 hairless mice compared to that in the UVB-irradiated control group. Furthermore, FSH-ZM also inhibited the expression of inflammatory cytokines and wrinkle forming factors generated by UVB and reduced the formation of wrinkles in the test group relative to that in the control group by increasing collagen synthesis. Moreover, we found that FSH-ZM decreased the expression of melanogenesis factors, which improved depigmentation in UVB-irradiated hairless mice. These results suggest that <i>Zingiber mioga</i> can potentially be utilized to develop products aimed at improving skin moisturization and depigmentation and reducing wrinkle formation. |
| first_indexed | 2024-03-09T04:03:56Z |
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| language | English |
| last_indexed | 2024-03-09T04:03:56Z |
| publishDate | 2021-01-01 |
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| spelling | doaj.art-ca54be80a92e412eacf63a9980184f562023-12-03T14:10:04ZengMDPI AGApplied Sciences2076-34172021-01-0111397610.3390/app11030976<i>Zingiber mioga</i> Extract Improves Moisturization and Depigmentation of Skin and Reduces Wrinkle Formation in UVB-Irradiated HRM-2 Hairless MiceSoo-Jeung Park0Minhee Lee1Jeong-Moon Yun2Dakyung Kim3Jeonmin Lee4Yoo-Hyun Lee5Clinical Nutrition Institute, Kyung Hee University, Seoul 02247, KoreaClinical Nutrition Institute, Kyung Hee University, Seoul 02247, KoreaClinical Nutrition Institute, Kyung Hee University, Seoul 02247, KoreaClinical Nutrition Institute, Kyung Hee University, Seoul 02247, KoreaClinical Nutrition Institute, Kyung Hee University, Seoul 02247, KoreaDepartment of Food Science and Nutrition, The University of Suwon, Hwaseong 18323, KoreaHere, we investigated the effects of <i>Zingiber mioga</i> extracts (FSH-ZM) on the moisturization and depigmentation of skin as well as wrinkle formation in UVB-irradiated HRM-2 hairless mice. The mice were divided into six groups as follows: normal control (NC), UVB-irradiated control (C), positive control 1 (PC1, L-ascorbic acid 200 mg/kg b.w.), positive control 2 (PC2, Arbutin 200 mg/kg b.w.), Z100 (FSH-ZM 100 mg/kg b.w.), and Z200 (FSH-ZM 200 mg/kg b.w.). The experiment spanned a period of 6 weeks. We found that FSH-ZM led to an increase in the expression of hyaluronan synthase 2, fibrillin-1, and elastin mRNAs, and showed improved skin hydration in HRM-2 hairless mice compared to that in the UVB-irradiated control group. Furthermore, FSH-ZM also inhibited the expression of inflammatory cytokines and wrinkle forming factors generated by UVB and reduced the formation of wrinkles in the test group relative to that in the control group by increasing collagen synthesis. Moreover, we found that FSH-ZM decreased the expression of melanogenesis factors, which improved depigmentation in UVB-irradiated hairless mice. These results suggest that <i>Zingiber mioga</i> can potentially be utilized to develop products aimed at improving skin moisturization and depigmentation and reducing wrinkle formation.https://www.mdpi.com/2076-3417/11/3/976<i>Zingiber mioga</i>moisturizingwrinkle improvementwhitening |
| spellingShingle | Soo-Jeung Park Minhee Lee Jeong-Moon Yun Dakyung Kim Jeonmin Lee Yoo-Hyun Lee <i>Zingiber mioga</i> Extract Improves Moisturization and Depigmentation of Skin and Reduces Wrinkle Formation in UVB-Irradiated HRM-2 Hairless Mice Applied Sciences <i>Zingiber mioga</i> moisturizing wrinkle improvement whitening |
| title | <i>Zingiber mioga</i> Extract Improves Moisturization and Depigmentation of Skin and Reduces Wrinkle Formation in UVB-Irradiated HRM-2 Hairless Mice |
| title_full | <i>Zingiber mioga</i> Extract Improves Moisturization and Depigmentation of Skin and Reduces Wrinkle Formation in UVB-Irradiated HRM-2 Hairless Mice |
| title_fullStr | <i>Zingiber mioga</i> Extract Improves Moisturization and Depigmentation of Skin and Reduces Wrinkle Formation in UVB-Irradiated HRM-2 Hairless Mice |
| title_full_unstemmed | <i>Zingiber mioga</i> Extract Improves Moisturization and Depigmentation of Skin and Reduces Wrinkle Formation in UVB-Irradiated HRM-2 Hairless Mice |
| title_short | <i>Zingiber mioga</i> Extract Improves Moisturization and Depigmentation of Skin and Reduces Wrinkle Formation in UVB-Irradiated HRM-2 Hairless Mice |
| title_sort | i zingiber mioga i extract improves moisturization and depigmentation of skin and reduces wrinkle formation in uvb irradiated hrm 2 hairless mice |
| topic | <i>Zingiber mioga</i> moisturizing wrinkle improvement whitening |
| url | https://www.mdpi.com/2076-3417/11/3/976 |
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