Changes in cultured endothelial cell glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparin

Changes in cultured endothelial cell glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparin

<p>Abstract</p> <p>Background</p> <p>Heparan sulfate proteoglycans (HSPGs) contain glycosaminoglycan (GAG) chains made primarily of heparan sulfate (HS). Hyperglycemia in diabetes leads to endothelial injury and nephropathy, retinopathy and atherosclerosis. Decreased HS...

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Bibliographic Details
Main Authors: Linhardt Robert J, Xie Jin, Zhang Fuming, Han Juying, Hiebert Linda M
Format: Article
Language:English
Published: BMC 2009-08-01
Series:Cardiovascular Diabetology
Online Access:http://www.cardiab.com/content/8/1/46

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