Benign Parathyroid Adenoma Presenting with Unusual Parathyroid Crisis, Anemia and Myelofibrosis
Although the clinical symptoms of patients with benign parathyroid adenoma are usually nonspecific and benign, a malignant presentation of the benign disease may sometimes occur. Here, we report a case of a 58-year-old woman who presented with aggravated sacrum pain, general malaise, and polydipsia....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2007-01-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664609603466 |
| _version_ | 1818910520966643712 |
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| author | Shu-Chuan Huang Vin-Cent Wu Guan Chou Tzu-Yu Huang Shih-Yi Lin Wayne Huey-Herng Sheu |
| author_facet | Shu-Chuan Huang Vin-Cent Wu Guan Chou Tzu-Yu Huang Shih-Yi Lin Wayne Huey-Herng Sheu |
| author_sort | Shu-Chuan Huang |
| collection | DOAJ |
| description | Although the clinical symptoms of patients with benign parathyroid adenoma are usually nonspecific and benign, a malignant presentation of the benign disease may sometimes occur. Here, we report a case of a 58-year-old woman who presented with aggravated sacrum pain, general malaise, and polydipsia. Initial laboratory findings revealed hypercalcemia, normocytic anemia, and impaired renal function. Acute hyper-calcemic crisis manifested and primary hyperparathyroidism was diagnosed together with myelofibrosis on account of the result of bone marrow biopsy. Excision of a parathyroid adenoma was performed, and the anemia and bone marker regressed later. These findings suggested that benign parathyroid adenoma may mimic the clinical presentation of parathyroid carcinoma, releasing excess parathyroid hormone and resulting in hyperparathyroid crisis. In addition, primary hyperparathyroidism can be associated with anemia and myelofibrosis. [J Formos Med Assoc 2007;106(2 Suppl):S13-S16] |
| first_indexed | 2024-12-19T22:44:07Z |
| format | Article |
| id | doaj.art-ca59a0d998194845bb4703a68c637784 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-19T22:44:07Z |
| publishDate | 2007-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-ca59a0d998194845bb4703a68c6377842022-12-21T20:03:00ZengElsevierJournal of the Formosan Medical Association0929-66462007-01-011062S13S1610.1016/S0929-6646(09)60346-6Benign Parathyroid Adenoma Presenting with Unusual Parathyroid Crisis, Anemia and MyelofibrosisShu-Chuan Huang0Vin-Cent Wu1Guan Chou2Tzu-Yu Huang3Shih-Yi Lin4Wayne Huey-Herng Sheu5Division of Endocrinology and Metabolism, Department of Internal Medicine, Taoyuan Veterans Hospital, Taoyuan, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pathology, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Pathology, Taichung Veterans General Hospital, Taichung, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, TaiwanAlthough the clinical symptoms of patients with benign parathyroid adenoma are usually nonspecific and benign, a malignant presentation of the benign disease may sometimes occur. Here, we report a case of a 58-year-old woman who presented with aggravated sacrum pain, general malaise, and polydipsia. Initial laboratory findings revealed hypercalcemia, normocytic anemia, and impaired renal function. Acute hyper-calcemic crisis manifested and primary hyperparathyroidism was diagnosed together with myelofibrosis on account of the result of bone marrow biopsy. Excision of a parathyroid adenoma was performed, and the anemia and bone marker regressed later. These findings suggested that benign parathyroid adenoma may mimic the clinical presentation of parathyroid carcinoma, releasing excess parathyroid hormone and resulting in hyperparathyroid crisis. In addition, primary hyperparathyroidism can be associated with anemia and myelofibrosis. [J Formos Med Assoc 2007;106(2 Suppl):S13-S16]http://www.sciencedirect.com/science/article/pii/S0929664609603466anemiahyperparathyroidismmyelofibrosis |
| spellingShingle | Shu-Chuan Huang Vin-Cent Wu Guan Chou Tzu-Yu Huang Shih-Yi Lin Wayne Huey-Herng Sheu Benign Parathyroid Adenoma Presenting with Unusual Parathyroid Crisis, Anemia and Myelofibrosis Journal of the Formosan Medical Association anemia hyperparathyroidism myelofibrosis |
| title | Benign Parathyroid Adenoma Presenting with Unusual Parathyroid Crisis, Anemia and Myelofibrosis |
| title_full | Benign Parathyroid Adenoma Presenting with Unusual Parathyroid Crisis, Anemia and Myelofibrosis |
| title_fullStr | Benign Parathyroid Adenoma Presenting with Unusual Parathyroid Crisis, Anemia and Myelofibrosis |
| title_full_unstemmed | Benign Parathyroid Adenoma Presenting with Unusual Parathyroid Crisis, Anemia and Myelofibrosis |
| title_short | Benign Parathyroid Adenoma Presenting with Unusual Parathyroid Crisis, Anemia and Myelofibrosis |
| title_sort | benign parathyroid adenoma presenting with unusual parathyroid crisis anemia and myelofibrosis |
| topic | anemia hyperparathyroidism myelofibrosis |
| url | http://www.sciencedirect.com/science/article/pii/S0929664609603466 |
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