Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability
Background Weight loss through lifestyle modification is recommended for patients with nonalcoholic fatty liver disease (NAFLD). Recent studies have suggested that repeated loss and gain of weight is associated with worse health outcomes. This study aimed to examine the association between weight va...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2021-08-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.e-enm.org/upload/pdf/enm-2021-1098.pdf |
| _version_ | 1811331672131502080 |
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| author | Inha Jung Dae-Jeong Koo Mi Yeon Lee Sun Joon Moon Hyemi Kwon Se Eun Park Eun-Jung Rhee Won-Young Lee |
| author_facet | Inha Jung Dae-Jeong Koo Mi Yeon Lee Sun Joon Moon Hyemi Kwon Se Eun Park Eun-Jung Rhee Won-Young Lee |
| author_sort | Inha Jung |
| collection | DOAJ |
| description | Background Weight loss through lifestyle modification is recommended for patients with nonalcoholic fatty liver disease (NAFLD). Recent studies have suggested that repeated loss and gain of weight is associated with worse health outcomes. This study aimed to examine the association between weight variability and the risk of NAFLD in patients without diabetes. Methods We examined the health-checkup data of 30,708 participants who had undergone serial examinations between 2010 and 2014. Weight variability was assessed using coefficient of variation and the average successive variability of weight (ASVW), which was defined as the sum of absolute weight changes between successive years over the 5-year period divided by 4. The participants were classified according to the baseline body mass index and weight difference over 4 years. Results On dividing the participants into four groups according to ASVW quartile groups, those in the highest quartile showed a significantly increased risk of NAFLD compared to those in the lowest quartile (odds ratio [OR], 1.89; 95% confidence interval [CI], 1.63 to 2.19). Among participants without obesity at baseline, individuals with high ASVW showed increased risk of NAFLD (OR, 1.80; 95% CI, 1.61 to 2.01). Participants with increased weight over 4 years and high ASVW demonstrated higher risk of NAFLD compared to those with stable weight and low ASVW (OR, 4.87; 95% CI, 4.29 to 5.53). Conclusion Regardless of participant baseline obesity status, high weight variability was associated with an increased risk of developing NAFLD. Our results suggest that further effort is required to minimize weight fluctuations after achieving a desirable body weight. |
| first_indexed | 2024-04-13T16:24:11Z |
| format | Article |
| id | doaj.art-ca59f57595f5490bb5a9403ca6828614 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-04-13T16:24:11Z |
| publishDate | 2021-08-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-ca59f57595f5490bb5a9403ca68286142022-12-22T02:39:48ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782021-08-0136484585410.3803/EnM.2021.10982211Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight VariabilityInha Jung0Dae-Jeong Koo1Mi Yeon Lee2Sun Joon Moon3Hyemi Kwon4Se Eun Park5Eun-Jung Rhee6Won-Young Lee7 Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Changwon Fatima Hospital, Changwon, Korea Division of Biostatistics, Department of R&D Management, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, KoreaBackground Weight loss through lifestyle modification is recommended for patients with nonalcoholic fatty liver disease (NAFLD). Recent studies have suggested that repeated loss and gain of weight is associated with worse health outcomes. This study aimed to examine the association between weight variability and the risk of NAFLD in patients without diabetes. Methods We examined the health-checkup data of 30,708 participants who had undergone serial examinations between 2010 and 2014. Weight variability was assessed using coefficient of variation and the average successive variability of weight (ASVW), which was defined as the sum of absolute weight changes between successive years over the 5-year period divided by 4. The participants were classified according to the baseline body mass index and weight difference over 4 years. Results On dividing the participants into four groups according to ASVW quartile groups, those in the highest quartile showed a significantly increased risk of NAFLD compared to those in the lowest quartile (odds ratio [OR], 1.89; 95% confidence interval [CI], 1.63 to 2.19). Among participants without obesity at baseline, individuals with high ASVW showed increased risk of NAFLD (OR, 1.80; 95% CI, 1.61 to 2.01). Participants with increased weight over 4 years and high ASVW demonstrated higher risk of NAFLD compared to those with stable weight and low ASVW (OR, 4.87; 95% CI, 4.29 to 5.53). Conclusion Regardless of participant baseline obesity status, high weight variability was associated with an increased risk of developing NAFLD. Our results suggest that further effort is required to minimize weight fluctuations after achieving a desirable body weight.http://www.e-enm.org/upload/pdf/enm-2021-1098.pdfbody weight maintenancebody weight changesfatty livernon-alcoholic fatty liver diseaseobesityinsulin resistance |
| spellingShingle | Inha Jung Dae-Jeong Koo Mi Yeon Lee Sun Joon Moon Hyemi Kwon Se Eun Park Eun-Jung Rhee Won-Young Lee Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability Endocrinology and Metabolism body weight maintenance body weight changes fatty liver non-alcoholic fatty liver disease obesity insulin resistance |
| title | Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability |
| title_full | Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability |
| title_fullStr | Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability |
| title_full_unstemmed | Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability |
| title_short | Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability |
| title_sort | increased risk of nonalcoholic fatty liver disease in individuals with high weight variability |
| topic | body weight maintenance body weight changes fatty liver non-alcoholic fatty liver disease obesity insulin resistance |
| url | http://www.e-enm.org/upload/pdf/enm-2021-1098.pdf |
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