Perspective—The Feasibility of Continuous Protein Monitoring in Interstitial Fluid
Real-time continuous monitoring of proteins in-vivo holds great potential for personalized medical applications. Unfortunately, a prominent knowledge gap exists in the fundamental biology regarding protein transfer and correlation between interstitial fluid and blood. Additionally, technological sen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2023-01-01
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| Series: | ECS Sensors Plus |
| Online Access: | https://doi.org/10.1149/2754-2726/accd7e |
| _version_ | 1797671015899201536 |
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| author | Thomas Young Vincent Clark Netzahualcóyotl Arroyo-Currás Jason Heikenfeld |
| author_facet | Thomas Young Vincent Clark Netzahualcóyotl Arroyo-Currás Jason Heikenfeld |
| author_sort | Thomas Young |
| collection | DOAJ |
| description | Real-time continuous monitoring of proteins in-vivo holds great potential for personalized medical applications. Unfortunately, a prominent knowledge gap exists in the fundamental biology regarding protein transfer and correlation between interstitial fluid and blood. Additionally, technological sensing will require affinity-based platforms that cannot be robustly protected in-vivo and will therefore be challenged in sensitivity, longevity, and fouling over multi-day to week timelines. Here we use electrochemical aptamer sensors as a model system to discuss further research necessary to achieve continuous protein sensing. |
| first_indexed | 2024-03-11T21:09:19Z |
| format | Article |
| id | doaj.art-ca5a7bbd79584cedb7161c90cb874fdb |
| institution | Directory Open Access Journal |
| issn | 2754-2726 |
| language | English |
| last_indexed | 2024-03-11T21:09:19Z |
| publishDate | 2023-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | ECS Sensors Plus |
| spelling | doaj.art-ca5a7bbd79584cedb7161c90cb874fdb2023-09-29T08:29:43ZengIOP PublishingECS Sensors Plus2754-27262023-01-012202700110.1149/2754-2726/accd7ePerspective—The Feasibility of Continuous Protein Monitoring in Interstitial FluidThomas Young0https://orcid.org/0000-0001-9311-1145Vincent Clark1https://orcid.org/0000-0001-9707-8004Netzahualcóyotl Arroyo-Currás2https://orcid.org/0000-0002-2740-6276Jason Heikenfeld3https://orcid.org/0000-0001-5778-8343Department of Biomedical Engineering, University of Cincinnati , Cincinnati, OH 45221, United States of AmericaChemistry-Biology Interface Program, Zanvyl Krieger School of Arts & Sciences, Johns Hopkins University, Baltimore, MD 21218, United States of AmericaChemistry-Biology Interface Program, Zanvyl Krieger School of Arts & Sciences, Johns Hopkins University, Baltimore, MD 21218, United States of AmericaDepartment of Biomedical Engineering, University of Cincinnati , Cincinnati, OH 45221, United States of America; Department of Electrical & Computer Engineering, University of Cincinnati , Cincinnati, OH 45221, United States of America; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States of AmericaReal-time continuous monitoring of proteins in-vivo holds great potential for personalized medical applications. Unfortunately, a prominent knowledge gap exists in the fundamental biology regarding protein transfer and correlation between interstitial fluid and blood. Additionally, technological sensing will require affinity-based platforms that cannot be robustly protected in-vivo and will therefore be challenged in sensitivity, longevity, and fouling over multi-day to week timelines. Here we use electrochemical aptamer sensors as a model system to discuss further research necessary to achieve continuous protein sensing.https://doi.org/10.1149/2754-2726/accd7e |
| spellingShingle | Thomas Young Vincent Clark Netzahualcóyotl Arroyo-Currás Jason Heikenfeld Perspective—The Feasibility of Continuous Protein Monitoring in Interstitial Fluid ECS Sensors Plus |
| title | Perspective—The Feasibility of Continuous Protein Monitoring in Interstitial Fluid |
| title_full | Perspective—The Feasibility of Continuous Protein Monitoring in Interstitial Fluid |
| title_fullStr | Perspective—The Feasibility of Continuous Protein Monitoring in Interstitial Fluid |
| title_full_unstemmed | Perspective—The Feasibility of Continuous Protein Monitoring in Interstitial Fluid |
| title_short | Perspective—The Feasibility of Continuous Protein Monitoring in Interstitial Fluid |
| title_sort | perspective the feasibility of continuous protein monitoring in interstitial fluid |
| url | https://doi.org/10.1149/2754-2726/accd7e |
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