Gastric mixed large cell neuroendocrine-adenosquamous carcinoma with heterogenous MSH6 loss in Lynch syndrome

Gastric mixed large cell neuroendocrine-adenosquamous carcinoma with heterogenous MSH6 loss in Lynch syndrome

Lynch syndrome (LS) is the most common hereditary gastrointestinal cancer predisposition syndrome and is caused by mutations in DNA mismatch repair (MMR) genes. Deficiency of MMR proteins manifests as the microsatellite instability-high (MSI-H) phenotype. Gastric cancer is the second most common non...

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Bibliographic Details
Main Authors: Jillian C. Dawley, Y. Haroon Ahmad, Taylor S. Riall, Belinda L. Sun
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Human Pathology Reports
Subjects:
Mixed neuroendocrine-adenosquamous carcinoma
Gastric cancer
Lynch Syndrome
DNA mismatch repair gene
Online Access:http://www.sciencedirect.com/science/article/pii/S2772736X21000323

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