Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract
Normal gastrointestinal function relies on sensing and transducing mechanical signals into changes in intracellular signaling pathways. Both specialized mechanosensing cells, such as certain enterochromaffin cells and enteric neurons, and non-specialized cells, such as smooth muscle cells, interstit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/1/177 |
| _version_ | 1797406865585340416 |
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| author | Job Baffin Kola Tibor Docsa Karen Uray |
| author_facet | Job Baffin Kola Tibor Docsa Karen Uray |
| author_sort | Job Baffin Kola |
| collection | DOAJ |
| description | Normal gastrointestinal function relies on sensing and transducing mechanical signals into changes in intracellular signaling pathways. Both specialized mechanosensing cells, such as certain enterochromaffin cells and enteric neurons, and non-specialized cells, such as smooth muscle cells, interstitial cells of Cajal, and resident macrophages, participate in physiological and pathological responses to mechanical signals in the gastrointestinal tract. We review the role of mechanosensors in the different cell types of the gastrointestinal tract. Then, we provide several examples of the role of mechanotransduction in normal physiology. These examples highlight the fact that, although these responses to mechanical signals have been known for decades, the mechanosensors involved in these responses to mechanical signals are largely unknown. Finally, we discuss several diseases involving the overstimulation or dysregulation of mechanotransductive pathways. Understanding these pathways and identifying the mechanosensors involved in these diseases may facilitate the identification of new drug targets to effectively treat these diseases. |
| first_indexed | 2024-03-09T03:32:48Z |
| format | Article |
| id | doaj.art-ca5c50b150054a14a9336f7e9aa084b1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T03:32:48Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ca5c50b150054a14a9336f7e9aa084b12023-12-03T14:54:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0124117710.3390/ijms24010177Mechanosensing in the Physiology and Pathology of the Gastrointestinal TractJob Baffin Kola0Tibor Docsa1Karen Uray2Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryNormal gastrointestinal function relies on sensing and transducing mechanical signals into changes in intracellular signaling pathways. Both specialized mechanosensing cells, such as certain enterochromaffin cells and enteric neurons, and non-specialized cells, such as smooth muscle cells, interstitial cells of Cajal, and resident macrophages, participate in physiological and pathological responses to mechanical signals in the gastrointestinal tract. We review the role of mechanosensors in the different cell types of the gastrointestinal tract. Then, we provide several examples of the role of mechanotransduction in normal physiology. These examples highlight the fact that, although these responses to mechanical signals have been known for decades, the mechanosensors involved in these responses to mechanical signals are largely unknown. Finally, we discuss several diseases involving the overstimulation or dysregulation of mechanotransductive pathways. Understanding these pathways and identifying the mechanosensors involved in these diseases may facilitate the identification of new drug targets to effectively treat these diseases.https://www.mdpi.com/1422-0067/24/1/177mechanotransductiongastrointestinalileusirritable bowel disease |
| spellingShingle | Job Baffin Kola Tibor Docsa Karen Uray Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract International Journal of Molecular Sciences mechanotransduction gastrointestinal ileus irritable bowel disease |
| title | Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract |
| title_full | Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract |
| title_fullStr | Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract |
| title_full_unstemmed | Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract |
| title_short | Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract |
| title_sort | mechanosensing in the physiology and pathology of the gastrointestinal tract |
| topic | mechanotransduction gastrointestinal ileus irritable bowel disease |
| url | https://www.mdpi.com/1422-0067/24/1/177 |
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