A ROS balance system with medication and photothermal therapy ability for burn treatment
In burns, reactive oxygen species (ROS) imbalance can lead to elevated oxidative damage and increase the difficulty of skin repair. However, rough removal of ROS will inevitably affect its' normal physiological function, leading to antibacterial failure and slow wound healing. To solve this pro...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
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| Series: | Journal of Science: Advanced Materials and Devices |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468217923000035 |
| _version_ | 1797820682061479936 |
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| author | Xiaoxia Wang Huijie Yang Guojuan Fan Ai Sun Jiamin Qin Jiaxuan Zhao Jingqi Zhang Weifen Zhang Hua Wang Jinlong Ma |
| author_facet | Xiaoxia Wang Huijie Yang Guojuan Fan Ai Sun Jiamin Qin Jiaxuan Zhao Jingqi Zhang Weifen Zhang Hua Wang Jinlong Ma |
| author_sort | Xiaoxia Wang |
| collection | DOAJ |
| description | In burns, reactive oxygen species (ROS) imbalance can lead to elevated oxidative damage and increase the difficulty of skin repair. However, rough removal of ROS will inevitably affect its' normal physiological function, leading to antibacterial failure and slow wound healing. To solve this problem, we developed a multifunctional AC-AuLA supramolecular polymer by combining medication therapy of asiaticoside (AC), photothermal therapy (PTT) of gold nanostars (AuNSs), and ROS-mediated of α-lipoic acid (LA). The AC-AuLA could create a normal ROS microenvironment for burns by regulating the balance between oxidants and antioxidants. At the same time, the AuNSs endow AC-AuLA with an excellent antibacterial effect, and the AC of AC-AuLA can promote wound repair through robust cell proliferation and angiogenesis. Importantly, in burn models infected with S. aureus, AC-AuLA achieves dense vascular formation and uniform collagen alignment, accelerating wound closure. These results indicate that this novel redox-sensitive supramolecular polymer has a broad application prospect in burn wound repair platforms. |
| first_indexed | 2024-03-13T09:41:51Z |
| format | Article |
| id | doaj.art-ca5d147f0c104c5d80e410310eaca5a4 |
| institution | Directory Open Access Journal |
| issn | 2468-2179 |
| language | English |
| last_indexed | 2024-03-13T09:41:51Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Science: Advanced Materials and Devices |
| spelling | doaj.art-ca5d147f0c104c5d80e410310eaca5a42023-05-25T04:24:45ZengElsevierJournal of Science: Advanced Materials and Devices2468-21792023-06-0182100534A ROS balance system with medication and photothermal therapy ability for burn treatmentXiaoxia Wang0Huijie Yang1Guojuan Fan2Ai Sun3Jiamin Qin4Jiaxuan Zhao5Jingqi Zhang6Weifen Zhang7Hua Wang8Jinlong Ma9School of Pharmacy, Weifang Medical University, Weifang, 261053, Shandong, ChinaSchool of Pharmacy, Weifang Medical University, Weifang, 261053, Shandong, ChinaDermatology, Weifang Hospital of Traditional Chinese Medicine, Weifang, 261000, Shandong, ChinaSchool of Pharmacy, Weifang Medical University, Weifang, 261053, Shandong, ChinaSchool of Pharmacy, Weifang Medical University, Weifang, 261053, Shandong, ChinaSchool of Pharmacy, Weifang Medical University, Weifang, 261053, Shandong, ChinaSchool of Pharmacy, Weifang Medical University, Weifang, 261053, Shandong, ChinaSchool of Pharmacy, Weifang Medical University, Weifang, 261053, Shandong, China; Collaborative Innovation Center for Target Drug Delivery System, Weifang Medical University, Weifang, 261053, Shandong, China; Shandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang, 261053, Shandong, China; Corresponding author. School of Pharmacy, Weifang Medical University, Weifang, 261053, Shandong, China.Huzhou Key Laboratory of Medical and Environmental Applications Technologies, School of Life Sciences, Huzhou University, Huzhou City, 313000, Zhejiang Province, China; Corresponding author. Huzhou Key Laboratory of Medical and Environmental Applications Technologies, School of Life Sciences, Huzhou University, Huzhou City 313000, Zhejiang Province, China.School of Pharmacy, Weifang Medical University, Weifang, 261053, Shandong, China; Collaborative Innovation Center for Target Drug Delivery System, Weifang Medical University, Weifang, 261053, Shandong, China; Shandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang, 261053, Shandong, China; Corresponding author. School of Pharmacy, Weifang Medical University, Weifang, 261053, Shandong, China.In burns, reactive oxygen species (ROS) imbalance can lead to elevated oxidative damage and increase the difficulty of skin repair. However, rough removal of ROS will inevitably affect its' normal physiological function, leading to antibacterial failure and slow wound healing. To solve this problem, we developed a multifunctional AC-AuLA supramolecular polymer by combining medication therapy of asiaticoside (AC), photothermal therapy (PTT) of gold nanostars (AuNSs), and ROS-mediated of α-lipoic acid (LA). The AC-AuLA could create a normal ROS microenvironment for burns by regulating the balance between oxidants and antioxidants. At the same time, the AuNSs endow AC-AuLA with an excellent antibacterial effect, and the AC of AC-AuLA can promote wound repair through robust cell proliferation and angiogenesis. Importantly, in burn models infected with S. aureus, AC-AuLA achieves dense vascular formation and uniform collagen alignment, accelerating wound closure. These results indicate that this novel redox-sensitive supramolecular polymer has a broad application prospect in burn wound repair platforms.http://www.sciencedirect.com/science/article/pii/S2468217923000035ROS BalanceAsiaticosidePhotothermal therapyBurn treatment |
| spellingShingle | Xiaoxia Wang Huijie Yang Guojuan Fan Ai Sun Jiamin Qin Jiaxuan Zhao Jingqi Zhang Weifen Zhang Hua Wang Jinlong Ma A ROS balance system with medication and photothermal therapy ability for burn treatment Journal of Science: Advanced Materials and Devices ROS Balance Asiaticoside Photothermal therapy Burn treatment |
| title | A ROS balance system with medication and photothermal therapy ability for burn treatment |
| title_full | A ROS balance system with medication and photothermal therapy ability for burn treatment |
| title_fullStr | A ROS balance system with medication and photothermal therapy ability for burn treatment |
| title_full_unstemmed | A ROS balance system with medication and photothermal therapy ability for burn treatment |
| title_short | A ROS balance system with medication and photothermal therapy ability for burn treatment |
| title_sort | ros balance system with medication and photothermal therapy ability for burn treatment |
| topic | ROS Balance Asiaticoside Photothermal therapy Burn treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2468217923000035 |
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