Ferroptosis: Biochemistry and Biology in Cancers
The challenge of eradicating cancer is that cancer cells possess diverse mechanisms to protect themselves from clinical strategies. Recently, ferroptosis has been shown to exhibit appreciable anti-tumor activity that could be harnessed for cancer therapy in the future. Ferroptosis is an iron-depende...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.579286/full |
| _version_ | 1819170610154045440 |
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| author | Zhiyuan Shi Lei Zhang Jianzhong Zheng Huimin Sun Chen Shao |
| author_facet | Zhiyuan Shi Lei Zhang Jianzhong Zheng Huimin Sun Chen Shao |
| author_sort | Zhiyuan Shi |
| collection | DOAJ |
| description | The challenge of eradicating cancer is that cancer cells possess diverse mechanisms to protect themselves from clinical strategies. Recently, ferroptosis has been shown to exhibit appreciable anti-tumor activity that could be harnessed for cancer therapy in the future. Ferroptosis is an iron-dependent form of regulated cell death that is characterized by the oxidization of polyunsaturated fatty acids (PUFAs) and accumulation of lipid peroxides. Ferroptosis has been closely correlated with numerous biological processes, such as amino acid metabolism, glutathione metabolism, iron metabolism, and lipid metabolism, as well as key regulators including GPX4, FSP1, NRF2, and p53. Although ferroptosis could be involved in killing various cancer cells, multiple aspects of this phenomenon remain unresolved. In this review, we summarize the biochemistry and biology of ferroptosis in diverse cancers and discuss the potential mechanisms of ferroptosis, which might pave the way for guiding cancer therapeutics. |
| first_indexed | 2024-12-22T19:38:08Z |
| format | Article |
| id | doaj.art-ca5d33ccc79d41009f53ae4870d99e4a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-22T19:38:08Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ca5d33ccc79d41009f53ae4870d99e4a2022-12-21T18:14:55ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-04-011110.3389/fonc.2021.579286579286Ferroptosis: Biochemistry and Biology in CancersZhiyuan Shi0Lei Zhang1Jianzhong Zheng2Huimin Sun3Chen Shao4Department of Urology, Xiang’an Hospital of Xiamen University, Xiamen, ChinaSchool of Public Health, Xiamen Univerisity, Xiamen, ChinaDepartment of Urology, Xiang’an Hospital of Xiamen University, Xiamen, ChinaClinical Central Research Core, Xiang’an Hospital of Xiamen University, Xiamen, ChinaDepartment of Urology, Xiang’an Hospital of Xiamen University, Xiamen, ChinaThe challenge of eradicating cancer is that cancer cells possess diverse mechanisms to protect themselves from clinical strategies. Recently, ferroptosis has been shown to exhibit appreciable anti-tumor activity that could be harnessed for cancer therapy in the future. Ferroptosis is an iron-dependent form of regulated cell death that is characterized by the oxidization of polyunsaturated fatty acids (PUFAs) and accumulation of lipid peroxides. Ferroptosis has been closely correlated with numerous biological processes, such as amino acid metabolism, glutathione metabolism, iron metabolism, and lipid metabolism, as well as key regulators including GPX4, FSP1, NRF2, and p53. Although ferroptosis could be involved in killing various cancer cells, multiple aspects of this phenomenon remain unresolved. In this review, we summarize the biochemistry and biology of ferroptosis in diverse cancers and discuss the potential mechanisms of ferroptosis, which might pave the way for guiding cancer therapeutics.https://www.frontiersin.org/articles/10.3389/fonc.2021.579286/fullferroptosiscancersamino acid metabolismiron metabolismlipid metabolism |
| spellingShingle | Zhiyuan Shi Lei Zhang Jianzhong Zheng Huimin Sun Chen Shao Ferroptosis: Biochemistry and Biology in Cancers Frontiers in Oncology ferroptosis cancers amino acid metabolism iron metabolism lipid metabolism |
| title | Ferroptosis: Biochemistry and Biology in Cancers |
| title_full | Ferroptosis: Biochemistry and Biology in Cancers |
| title_fullStr | Ferroptosis: Biochemistry and Biology in Cancers |
| title_full_unstemmed | Ferroptosis: Biochemistry and Biology in Cancers |
| title_short | Ferroptosis: Biochemistry and Biology in Cancers |
| title_sort | ferroptosis biochemistry and biology in cancers |
| topic | ferroptosis cancers amino acid metabolism iron metabolism lipid metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.579286/full |
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