Renal hyperfiltration, fatty liver index, and the hazards of all-cause and cardiovascular mortality in Finnish men
OBJECTIVES Renal hyperfiltration (RHF) and fatty liver are separately associated with adverse health outcomes. In this study, we investigated the mortality hazard of coexisting RHF and fatty liver. METHODS Middle-aged men from the Kuopio Ischaemic Disease Risk Factor Study (n=1,552) were followed up...
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| Format: | Article |
| Language: | English |
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Korean Society of Epidemiology
2020-12-01
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| Series: | Epidemiology and Health |
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| Online Access: | http://www.e-epih.org/upload/pdf/epih-43-e2021001.pdf |
| _version_ | 1818317242803159040 |
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| author | Mounir Ould Setti Ari Voutilainen Tomi-Pekka Tuomainen |
| author_facet | Mounir Ould Setti Ari Voutilainen Tomi-Pekka Tuomainen |
| author_sort | Mounir Ould Setti |
| collection | DOAJ |
| description | OBJECTIVES Renal hyperfiltration (RHF) and fatty liver are separately associated with adverse health outcomes. In this study, we investigated the mortality hazard of coexisting RHF and fatty liver. METHODS Middle-aged men from the Kuopio Ischaemic Disease Risk Factor Study (n=1,552) were followed up for a median of 29 years. Associations among RHF, fatty liver index (FLI) score, age, body mass index, smoking status, alcohol consumption, and hypertension status were assessed using logistic regression. Cox proportional hazards models were used to determine the hazard ratios (HRs) for all-cause and cardiovascular disease (CVD) mortality with respect to RHF and fatty liver. RESULTS Of the men, 5% had RHF (n=73), whereas a majority had fatty liver (n=848). RHF was associated specifically with smoking, and fatty liver was associated specifically with overweight. The all-cause mortality hazard was highest (HR, 1.96; 95% confidence interval [CI], 1.27 to 3.01) among men with RHF and fatty liver (n=33). Among men with RHF but normal FLI (n=40), the HR of all-cause mortality was 1.67 (95% CI, 1.15 to 2.42). Among men with fatty liver but a normal estimated glomerular filtration rate (n=527), the HR of all-cause mortality was 1.35 (95% CI, 1.09 to 1.66). CVD mortality hazard was associated with RHF, but not fatty liver. We detected no interaction effect between RHF and fatty liver for all-cause (synergy index, 0.74; 95% CI, 0.21 to 2.67) or CVD (synergy index, 0.94; 95% CI, 0.34 to 2.60) mortality. CONCLUSIONS RHF and fatty liver are independently associated with all-cause and CVD mortality |
| first_indexed | 2024-12-13T09:34:13Z |
| format | Article |
| id | doaj.art-ca5d43d19f444b9f84426bc9bb1c6220 |
| institution | Directory Open Access Journal |
| issn | 2092-7193 |
| language | English |
| last_indexed | 2024-12-13T09:34:13Z |
| publishDate | 2020-12-01 |
| publisher | Korean Society of Epidemiology |
| record_format | Article |
| series | Epidemiology and Health |
| spelling | doaj.art-ca5d43d19f444b9f84426bc9bb1c62202022-12-21T23:52:24ZengKorean Society of EpidemiologyEpidemiology and Health2092-71932020-12-014310.4178/epih.e20210011143Renal hyperfiltration, fatty liver index, and the hazards of all-cause and cardiovascular mortality in Finnish menMounir Ould Setti0Ari Voutilainen1Tomi-Pekka Tuomainen2 Department of Public Health, University of Eastern Finland, Kuopio, Finland Department of Public Health, University of Eastern Finland, Kuopio, Finland Department of Public Health, University of Eastern Finland, Kuopio, FinlandOBJECTIVES Renal hyperfiltration (RHF) and fatty liver are separately associated with adverse health outcomes. In this study, we investigated the mortality hazard of coexisting RHF and fatty liver. METHODS Middle-aged men from the Kuopio Ischaemic Disease Risk Factor Study (n=1,552) were followed up for a median of 29 years. Associations among RHF, fatty liver index (FLI) score, age, body mass index, smoking status, alcohol consumption, and hypertension status were assessed using logistic regression. Cox proportional hazards models were used to determine the hazard ratios (HRs) for all-cause and cardiovascular disease (CVD) mortality with respect to RHF and fatty liver. RESULTS Of the men, 5% had RHF (n=73), whereas a majority had fatty liver (n=848). RHF was associated specifically with smoking, and fatty liver was associated specifically with overweight. The all-cause mortality hazard was highest (HR, 1.96; 95% confidence interval [CI], 1.27 to 3.01) among men with RHF and fatty liver (n=33). Among men with RHF but normal FLI (n=40), the HR of all-cause mortality was 1.67 (95% CI, 1.15 to 2.42). Among men with fatty liver but a normal estimated glomerular filtration rate (n=527), the HR of all-cause mortality was 1.35 (95% CI, 1.09 to 1.66). CVD mortality hazard was associated with RHF, but not fatty liver. We detected no interaction effect between RHF and fatty liver for all-cause (synergy index, 0.74; 95% CI, 0.21 to 2.67) or CVD (synergy index, 0.94; 95% CI, 0.34 to 2.60) mortality. CONCLUSIONS RHF and fatty liver are independently associated with all-cause and CVD mortalityhttp://www.e-epih.org/upload/pdf/epih-43-e2021001.pdfmortalitycardiovascular diseasesheart disease risk factorsglomerular filtration ratefatty livernon-alcoholic fatty liver disease |
| spellingShingle | Mounir Ould Setti Ari Voutilainen Tomi-Pekka Tuomainen Renal hyperfiltration, fatty liver index, and the hazards of all-cause and cardiovascular mortality in Finnish men Epidemiology and Health mortality cardiovascular diseases heart disease risk factors glomerular filtration rate fatty liver non-alcoholic fatty liver disease |
| title | Renal hyperfiltration, fatty liver index, and the hazards of all-cause and cardiovascular mortality in Finnish men |
| title_full | Renal hyperfiltration, fatty liver index, and the hazards of all-cause and cardiovascular mortality in Finnish men |
| title_fullStr | Renal hyperfiltration, fatty liver index, and the hazards of all-cause and cardiovascular mortality in Finnish men |
| title_full_unstemmed | Renal hyperfiltration, fatty liver index, and the hazards of all-cause and cardiovascular mortality in Finnish men |
| title_short | Renal hyperfiltration, fatty liver index, and the hazards of all-cause and cardiovascular mortality in Finnish men |
| title_sort | renal hyperfiltration fatty liver index and the hazards of all cause and cardiovascular mortality in finnish men |
| topic | mortality cardiovascular diseases heart disease risk factors glomerular filtration rate fatty liver non-alcoholic fatty liver disease |
| url | http://www.e-epih.org/upload/pdf/epih-43-e2021001.pdf |
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