Role of Calcium Signaling in GA101-Induced Cell Death in Malignant Human B Cells

Role of Calcium Signaling in GA101-Induced Cell Death in Malignant Human B Cells

GA101/obinutuzumab is a novel type II anti-CD20 monoclonal antibody (mAb), which is more effective than rituximab (RTX) in preclinical and clinical studies when used in combination with chemotherapy. Ca2+ signaling was shown to play a role in RTX-induced cell death. This report concerns the effect o...

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Bibliographic Details
Main Authors: Simon Latour, Marion Zanese, Valérie Le Morvan, Anne-Marie Vacher, Nelly Menard, Fontanet Bijou, Francoise Durrieu, Pierre Soubeyran, Ariel Savina, Pierre Vacher, Laurence Bresson-Bepoldin
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
anti-CD20
GA101
calcium signaling
malignant B cells
cell death
Online Access:http://www.mdpi.com/2072-6694/11/3/291

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