FGL2 deficiency alleviates maternal inflammation-induced blood-brain barrier damage by blocking PI3K/NF-κB mediated endothelial oxidative stress

FGL2 deficiency alleviates maternal inflammation-induced blood-brain barrier damage by blocking PI3K/NF-κB mediated endothelial oxidative stress

IntroductionThe impairment of blood-brain barrier (BBB) is one of the key contributors to maternal inflammation induced brain damage in offspring. Our previous studies showed Fibrinogen-like protein 2 (FGL2) deficiency alleviated maternal inflammation induced perinatal brain damage. However, its rol...

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Bibliographic Details
Main Authors:	Lianjing Huang, Di Zhan, Ying Xing, Yaqin Yan, Qing Li, Jingyi Zhang, Sujuan Li, Qin Ning, Cai Zhang, Xiaoping Luo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Series:	Frontiers in Immunology
Subjects:	fibrinogen-like protein 2 maternal inflammation blood-brain barrier endothelial cells oxidative stress
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1157027/full

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