Circulating biomarkers associated with aortic diameter in male and female patients with thoracic aortic disease: a cross-sectional study
Objective As thoracic aortic disease (TAD) is generally asymptomatic, biomarkers are needed to provide insight into early progression. We aimed to examine the association between circulating blood biomarkers and the maximal thoracic aortic diameter (TADmax).Methods In this cross-sectional study, con...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2023-06-01
|
| Series: | Open Heart |
| Online Access: | https://openheart.bmj.com/content/10/1/e002317.full |
| _version_ | 1797741222600638464 |
|---|---|
| author | Jolien W Roos-Hesselink Johanna J M Takkenberg Eric Boersma Yolanda B de Rijke Lidia R Bons Roland R L van Kimmenade Jos A Bekkers Carlijn G E Thijssen Arjen L Gökalp Mostafa M Mokhles Frederike Meccanici Annemien E van der Bosch Silvy Dekker Elke Bouwens |
| author_facet | Jolien W Roos-Hesselink Johanna J M Takkenberg Eric Boersma Yolanda B de Rijke Lidia R Bons Roland R L van Kimmenade Jos A Bekkers Carlijn G E Thijssen Arjen L Gökalp Mostafa M Mokhles Frederike Meccanici Annemien E van der Bosch Silvy Dekker Elke Bouwens |
| author_sort | Jolien W Roos-Hesselink |
| collection | DOAJ |
| description | Objective As thoracic aortic disease (TAD) is generally asymptomatic, biomarkers are needed to provide insight into early progression. We aimed to examine the association between circulating blood biomarkers and the maximal thoracic aortic diameter (TADmax).Methods In this cross-sectional study, consecutive adult patients with a thoracic aortic diameter ≥40 mm and/or genetically proven hereditary TAD (HTAD) visiting our specialised outpatient clinic between 2017 and 2020 were prospectively included. Venous blood sampling and CT angiography and/or transthoracic echocardiography of the aorta were performed. Linear regression analyses were performed and estimates were presented as mean difference in TADmax in mm per doubling of standardised biomarker level.Results In total, 158 patients were included (median age 61 (50.3–68.8) years, 37.3% female). HTAD diagnosis was confirmed in 36 of 158 (22.7%) patients. TADmax was 43.9±5.2 mm in men vs 41.9±5.1 in women (p=0.030). In unadjusted analysis, significant associations with TADmax were found for interleukin-6 (1.15 (95% CI 0.33 to 1.96), p=0.006), growth differentiation factor-15 (1.01 (95% CI 0.18 to 1.84), p=0.018), microfibrillar-associated protein 4 (MFAP4) (−0.88 (95% CI −1.71 to 0.05), p=0.039) and triiodothyronine (T3) (−2.00 (95%CI −3.01 to 0.99), p<0.001). The association of MFAP4 with TADmax was stronger in women (p for interaction=0.020) and for homocysteine, an inverse association with TADmax was observed when compared with men (p for interaction=0.008). When adjusted for age, sex, hyperlipidaemia and HTAD, total cholesterol (1.10 (95% CI 0.27 to 1.93), p=0.010) and T3 (−1.20 (95% CI −2.14 to 0.25), p=0.014) were significantly associated with TADmax.Conclusions Circulating biomarkers indicative of inflammation, lipid metabolism and thyroid function might be associated with TAD severity. Possible distinct biomarker patterns for men and women warrant further investigation. |
| first_indexed | 2024-03-12T14:23:42Z |
| format | Article |
| id | doaj.art-ca61400e8c3e438cb62e518f313b0d19 |
| institution | Directory Open Access Journal |
| issn | 2053-3624 |
| language | English |
| last_indexed | 2024-03-12T14:23:42Z |
| publishDate | 2023-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Open Heart |
| spelling | doaj.art-ca61400e8c3e438cb62e518f313b0d192023-08-18T14:05:07ZengBMJ Publishing GroupOpen Heart2053-36242023-06-0110110.1136/openhrt-2023-002317Circulating biomarkers associated with aortic diameter in male and female patients with thoracic aortic disease: a cross-sectional studyJolien W Roos-Hesselink0Johanna J M Takkenberg1Eric Boersma2Yolanda B de Rijke3Lidia R Bons4Roland R L van Kimmenade5Jos A Bekkers6Carlijn G E Thijssen7Arjen L Gökalp8Mostafa M Mokhles9Frederike Meccanici10Annemien E van der Bosch11Silvy Dekker12Elke Bouwens13professor of cardiology4 Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, Zuid-Holland, The Netherlands3 Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, NetherlandsDepartment of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands1 Cardiology, Erasmus Medical Center, Rotterdam, The NetherlandsCardiology, Erasmus University Medical Center, Rotterdam, The NetherlandsDepartment of Cardio-Thoracic Surgery, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Cardiology, Erasmus MC, Rotterdam, The Netherlands6 Cardiothoracic Surgery, Erasmus MC, Rotterdam, The NetherlandsCardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands1 Cardiology, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Cardiology, Erasmus Medical Center, Rotterdam, The NetherlandsCardiology, Erasmus University Medical Center, Rotterdam, The NetherlandsCardiology, Erasmus University Medical Center, Rotterdam, The NetherlandsObjective As thoracic aortic disease (TAD) is generally asymptomatic, biomarkers are needed to provide insight into early progression. We aimed to examine the association between circulating blood biomarkers and the maximal thoracic aortic diameter (TADmax).Methods In this cross-sectional study, consecutive adult patients with a thoracic aortic diameter ≥40 mm and/or genetically proven hereditary TAD (HTAD) visiting our specialised outpatient clinic between 2017 and 2020 were prospectively included. Venous blood sampling and CT angiography and/or transthoracic echocardiography of the aorta were performed. Linear regression analyses were performed and estimates were presented as mean difference in TADmax in mm per doubling of standardised biomarker level.Results In total, 158 patients were included (median age 61 (50.3–68.8) years, 37.3% female). HTAD diagnosis was confirmed in 36 of 158 (22.7%) patients. TADmax was 43.9±5.2 mm in men vs 41.9±5.1 in women (p=0.030). In unadjusted analysis, significant associations with TADmax were found for interleukin-6 (1.15 (95% CI 0.33 to 1.96), p=0.006), growth differentiation factor-15 (1.01 (95% CI 0.18 to 1.84), p=0.018), microfibrillar-associated protein 4 (MFAP4) (−0.88 (95% CI −1.71 to 0.05), p=0.039) and triiodothyronine (T3) (−2.00 (95%CI −3.01 to 0.99), p<0.001). The association of MFAP4 with TADmax was stronger in women (p for interaction=0.020) and for homocysteine, an inverse association with TADmax was observed when compared with men (p for interaction=0.008). When adjusted for age, sex, hyperlipidaemia and HTAD, total cholesterol (1.10 (95% CI 0.27 to 1.93), p=0.010) and T3 (−1.20 (95% CI −2.14 to 0.25), p=0.014) were significantly associated with TADmax.Conclusions Circulating biomarkers indicative of inflammation, lipid metabolism and thyroid function might be associated with TAD severity. Possible distinct biomarker patterns for men and women warrant further investigation.https://openheart.bmj.com/content/10/1/e002317.full |
| spellingShingle | Jolien W Roos-Hesselink Johanna J M Takkenberg Eric Boersma Yolanda B de Rijke Lidia R Bons Roland R L van Kimmenade Jos A Bekkers Carlijn G E Thijssen Arjen L Gökalp Mostafa M Mokhles Frederike Meccanici Annemien E van der Bosch Silvy Dekker Elke Bouwens Circulating biomarkers associated with aortic diameter in male and female patients with thoracic aortic disease: a cross-sectional study Open Heart |
| title | Circulating biomarkers associated with aortic diameter in male and female patients with thoracic aortic disease: a cross-sectional study |
| title_full | Circulating biomarkers associated with aortic diameter in male and female patients with thoracic aortic disease: a cross-sectional study |
| title_fullStr | Circulating biomarkers associated with aortic diameter in male and female patients with thoracic aortic disease: a cross-sectional study |
| title_full_unstemmed | Circulating biomarkers associated with aortic diameter in male and female patients with thoracic aortic disease: a cross-sectional study |
| title_short | Circulating biomarkers associated with aortic diameter in male and female patients with thoracic aortic disease: a cross-sectional study |
| title_sort | circulating biomarkers associated with aortic diameter in male and female patients with thoracic aortic disease a cross sectional study |
| url | https://openheart.bmj.com/content/10/1/e002317.full |
| work_keys_str_mv | AT jolienwrooshesselink circulatingbiomarkersassociatedwithaorticdiameterinmaleandfemalepatientswiththoracicaorticdiseaseacrosssectionalstudy AT johannajmtakkenberg circulatingbiomarkersassociatedwithaorticdiameterinmaleandfemalepatientswiththoracicaorticdiseaseacrosssectionalstudy AT ericboersma circulatingbiomarkersassociatedwithaorticdiameterinmaleandfemalepatientswiththoracicaorticdiseaseacrosssectionalstudy AT yolandabderijke circulatingbiomarkersassociatedwithaorticdiameterinmaleandfemalepatientswiththoracicaorticdiseaseacrosssectionalstudy AT lidiarbons circulatingbiomarkersassociatedwithaorticdiameterinmaleandfemalepatientswiththoracicaorticdiseaseacrosssectionalstudy AT rolandrlvankimmenade circulatingbiomarkersassociatedwithaorticdiameterinmaleandfemalepatientswiththoracicaorticdiseaseacrosssectionalstudy AT josabekkers circulatingbiomarkersassociatedwithaorticdiameterinmaleandfemalepatientswiththoracicaorticdiseaseacrosssectionalstudy AT carlijngethijssen circulatingbiomarkersassociatedwithaorticdiameterinmaleandfemalepatientswiththoracicaorticdiseaseacrosssectionalstudy AT arjenlgokalp circulatingbiomarkersassociatedwithaorticdiameterinmaleandfemalepatientswiththoracicaorticdiseaseacrosssectionalstudy AT mostafammokhles circulatingbiomarkersassociatedwithaorticdiameterinmaleandfemalepatientswiththoracicaorticdiseaseacrosssectionalstudy AT frederikemeccanici circulatingbiomarkersassociatedwithaorticdiameterinmaleandfemalepatientswiththoracicaorticdiseaseacrosssectionalstudy AT annemienevanderbosch circulatingbiomarkersassociatedwithaorticdiameterinmaleandfemalepatientswiththoracicaorticdiseaseacrosssectionalstudy AT silvydekker circulatingbiomarkersassociatedwithaorticdiameterinmaleandfemalepatientswiththoracicaorticdiseaseacrosssectionalstudy AT elkebouwens circulatingbiomarkersassociatedwithaorticdiameterinmaleandfemalepatientswiththoracicaorticdiseaseacrosssectionalstudy |