Altered Brain Activity in Strabismic Amblyopic Children as Determined by Regional Homogeneity: A Resting-State Functional Magnetic Resonance Imaging Study
ObjectiveEarlier research has determined that amblyopia or strabismus may cause remarkable brain anatomical and functional variations. Nonetheless, thus far, the spontaneous changes in brain activity in children with strabismus amblyopia (SA) remain unclear. The purpose of this study was to determin...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.879253/full |
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| author | Si-Wen Tan Si-Wen Tan Guo-Qian Cai Qiu-Yu Li Yu Guo Yi-Cong Pan Li-Juan Zhang Qian-Min Ge Hui-Ye Shu Xian-Jun Zeng Yi Shao |
| author_facet | Si-Wen Tan Si-Wen Tan Guo-Qian Cai Qiu-Yu Li Yu Guo Yi-Cong Pan Li-Juan Zhang Qian-Min Ge Hui-Ye Shu Xian-Jun Zeng Yi Shao |
| author_sort | Si-Wen Tan |
| collection | DOAJ |
| description | ObjectiveEarlier research has determined that amblyopia or strabismus may cause remarkable brain anatomical and functional variations. Nonetheless, thus far, the spontaneous changes in brain activity in children with strabismus amblyopia (SA) remain unclear. The purpose of this study was to determine the association between abnormal brain activity in children with SA and its behavioral manifestations.Patients and Methods?A total of 24 children with SA (10 male and 14 female children) as well as 24 healthy controls (HCs), including 10 male and 14 female children were closely matched in sex and age, and examined using resting-state functional magnetic resonance imaging (fMRI). The regional homogeneity (ReHo) technique was applied to evaluate spontaneous cerebral activity variations in children with SA and HCs. Moreover, associations between altered ReHo values in distinct cerebral areas and the degree of strabismus were assessed using Pearson correlation analysis.ResultsRemarkably increased ReHo values were observed in the right lingual, right superior frontal medial, bilateral superior parietal, and right inferior parietal gyri of children with SA compared with HCs. In contrast, mean ReHo values in children with SA were lower in the right cerebellum, left superior frontal gyrus, and left putamen nucleus. Furthermore, esotropia showed a positive correlation with ReHo values of the left putamen.ConclusionThe anomalous spontaneous activity changes in several brain areas that are caused by SA may indicate neuropathologic mechanisms of visual deficits and oculomotor disorders in children with SA. |
| first_indexed | 2024-12-12T12:01:03Z |
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| language | English |
| last_indexed | 2024-12-12T12:01:03Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-ca6364b8abe344e49328ca16fbb334062022-12-22T00:25:07ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-06-011610.3389/fnins.2022.879253879253Altered Brain Activity in Strabismic Amblyopic Children as Determined by Regional Homogeneity: A Resting-State Functional Magnetic Resonance Imaging StudySi-Wen Tan0Si-Wen Tan1Guo-Qian Cai2Qiu-Yu Li3Yu Guo4Yi-Cong Pan5Li-Juan Zhang6Qian-Min Ge7Hui-Ye Shu8Xian-Jun Zeng9Yi Shao10Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaThe First Clinical Medical College, Nanchang University, Nanchang, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaObjectiveEarlier research has determined that amblyopia or strabismus may cause remarkable brain anatomical and functional variations. Nonetheless, thus far, the spontaneous changes in brain activity in children with strabismus amblyopia (SA) remain unclear. The purpose of this study was to determine the association between abnormal brain activity in children with SA and its behavioral manifestations.Patients and Methods?A total of 24 children with SA (10 male and 14 female children) as well as 24 healthy controls (HCs), including 10 male and 14 female children were closely matched in sex and age, and examined using resting-state functional magnetic resonance imaging (fMRI). The regional homogeneity (ReHo) technique was applied to evaluate spontaneous cerebral activity variations in children with SA and HCs. Moreover, associations between altered ReHo values in distinct cerebral areas and the degree of strabismus were assessed using Pearson correlation analysis.ResultsRemarkably increased ReHo values were observed in the right lingual, right superior frontal medial, bilateral superior parietal, and right inferior parietal gyri of children with SA compared with HCs. In contrast, mean ReHo values in children with SA were lower in the right cerebellum, left superior frontal gyrus, and left putamen nucleus. Furthermore, esotropia showed a positive correlation with ReHo values of the left putamen.ConclusionThe anomalous spontaneous activity changes in several brain areas that are caused by SA may indicate neuropathologic mechanisms of visual deficits and oculomotor disorders in children with SA.https://www.frontiersin.org/articles/10.3389/fnins.2022.879253/fullstrabismus amblyopiaregional homogeneityresting-state functional MRIchildrenReHo |
| spellingShingle | Si-Wen Tan Si-Wen Tan Guo-Qian Cai Qiu-Yu Li Yu Guo Yi-Cong Pan Li-Juan Zhang Qian-Min Ge Hui-Ye Shu Xian-Jun Zeng Yi Shao Altered Brain Activity in Strabismic Amblyopic Children as Determined by Regional Homogeneity: A Resting-State Functional Magnetic Resonance Imaging Study Frontiers in Neuroscience strabismus amblyopia regional homogeneity resting-state functional MRI children ReHo |
| title | Altered Brain Activity in Strabismic Amblyopic Children as Determined by Regional Homogeneity: A Resting-State Functional Magnetic Resonance Imaging Study |
| title_full | Altered Brain Activity in Strabismic Amblyopic Children as Determined by Regional Homogeneity: A Resting-State Functional Magnetic Resonance Imaging Study |
| title_fullStr | Altered Brain Activity in Strabismic Amblyopic Children as Determined by Regional Homogeneity: A Resting-State Functional Magnetic Resonance Imaging Study |
| title_full_unstemmed | Altered Brain Activity in Strabismic Amblyopic Children as Determined by Regional Homogeneity: A Resting-State Functional Magnetic Resonance Imaging Study |
| title_short | Altered Brain Activity in Strabismic Amblyopic Children as Determined by Regional Homogeneity: A Resting-State Functional Magnetic Resonance Imaging Study |
| title_sort | altered brain activity in strabismic amblyopic children as determined by regional homogeneity a resting state functional magnetic resonance imaging study |
| topic | strabismus amblyopia regional homogeneity resting-state functional MRI children ReHo |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.879253/full |
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