Small-Dose Sunitinib Modulates p53, Bcl-2, STAT3, and ERK1/2 Pathways and Protects against Adenine-Induced Nephrotoxicity

Small-Dose Sunitinib Modulates p53, Bcl-2, STAT3, and ERK1/2 Pathways and Protects against Adenine-Induced Nephrotoxicity

The therapeutic use of numerous pharmacological agents may be limited due to their nephrotoxicity and associated kidney injury. The aim of our study is to test the hypothesis that the blockade of tyrosine kinase-linked receptors signaling protects against chemically induced nephrotoxicity. To test o...

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Bibliographic Details
Main Authors: Mohamed A. Saleh, Ahmed M. Awad, Tarek M. Ibrahim, Nashwa M. Abu-Elsaad
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceuticals
Subjects:
sunitinib
p53
nephrotoxicity
TGF-β1
ERK1/2
Bcl-2
Online Access:https://www.mdpi.com/1424-8247/13/11/397

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