Non-alcoholic fatty liver disease is associated with increased risk of chronic kidney disease
Background and Aims: Whether non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of incident chronic kidney disease (CKD) independent of established cardio-renal risk factors remains controversial. We aimed to provide a quantitative estimate of the association and strength...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-06-01
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| Series: | Therapeutic Advances in Chronic Disease |
| Online Access: | https://doi.org/10.1177/20406223211024361 |
| _version_ | 1818591602547884032 |
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| author | Xiaoyan Cai Lichang Sun Xiong Liu Hailan Zhu Yang Zhang Sulin Zheng Yuli Huang |
| author_facet | Xiaoyan Cai Lichang Sun Xiong Liu Hailan Zhu Yang Zhang Sulin Zheng Yuli Huang |
| author_sort | Xiaoyan Cai |
| collection | DOAJ |
| description | Background and Aims: Whether non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of incident chronic kidney disease (CKD) independent of established cardio-renal risk factors remains controversial. We aimed to provide a quantitative estimate of the association and strength between NAFLD and risk of CKD after adjustment for multiple cardio-renal risk factors. Methods: We searched electronic databases (PubMed, Embase, and Google Scholar) for studies published from database inception until 30 November 2020. Analysis included cohort studies that reported multivariable-adjusted risk ratios [including odds ratios, relative risks (RRs), or hazard ratios] and 95% confidence intervals (CIs) for CKD of NAFLD compared with individuals without NAFLD. Results: A total of 11 cohort studies were included comprising 1,198,242 participants (46.3% women) for analysis. The median follow-up duration was 3.7 years, with 31,922 cases of incident CKD. Compared with individuals without NAFLD, unadjusted models showed that NAFLD was associated with a higher risk of CKD (RR 1.54, 95% CI 1.38–1.71). After adjusting for multiple cardio-renal risk factors, the CKD risk was still significantly increased in patients with NAFLD (RR 1.39, 95% CI 1.27–1.52). Compared with individuals without NAFLD, the adjusted absolute risk increase in NAFLD for CKD was 5.1 (95% CI 3.5–6.8) per 1000 person-years. Conclusion: NAFLD is associated with an increased risk of incident CKD independent of established cardio-renal risk factors. |
| first_indexed | 2024-12-16T10:15:03Z |
| format | Article |
| id | doaj.art-ca63d05d658543f5949815223de8e64a |
| institution | Directory Open Access Journal |
| issn | 2040-6231 |
| language | English |
| last_indexed | 2024-12-16T10:15:03Z |
| publishDate | 2021-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Chronic Disease |
| spelling | doaj.art-ca63d05d658543f5949815223de8e64a2022-12-21T22:35:28ZengSAGE PublishingTherapeutic Advances in Chronic Disease2040-62312021-06-011210.1177/20406223211024361Non-alcoholic fatty liver disease is associated with increased risk of chronic kidney diseaseXiaoyan CaiLichang SunXiong LiuHailan ZhuYang ZhangSulin ZhengYuli HuangBackground and Aims: Whether non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of incident chronic kidney disease (CKD) independent of established cardio-renal risk factors remains controversial. We aimed to provide a quantitative estimate of the association and strength between NAFLD and risk of CKD after adjustment for multiple cardio-renal risk factors. Methods: We searched electronic databases (PubMed, Embase, and Google Scholar) for studies published from database inception until 30 November 2020. Analysis included cohort studies that reported multivariable-adjusted risk ratios [including odds ratios, relative risks (RRs), or hazard ratios] and 95% confidence intervals (CIs) for CKD of NAFLD compared with individuals without NAFLD. Results: A total of 11 cohort studies were included comprising 1,198,242 participants (46.3% women) for analysis. The median follow-up duration was 3.7 years, with 31,922 cases of incident CKD. Compared with individuals without NAFLD, unadjusted models showed that NAFLD was associated with a higher risk of CKD (RR 1.54, 95% CI 1.38–1.71). After adjusting for multiple cardio-renal risk factors, the CKD risk was still significantly increased in patients with NAFLD (RR 1.39, 95% CI 1.27–1.52). Compared with individuals without NAFLD, the adjusted absolute risk increase in NAFLD for CKD was 5.1 (95% CI 3.5–6.8) per 1000 person-years. Conclusion: NAFLD is associated with an increased risk of incident CKD independent of established cardio-renal risk factors.https://doi.org/10.1177/20406223211024361 |
| spellingShingle | Xiaoyan Cai Lichang Sun Xiong Liu Hailan Zhu Yang Zhang Sulin Zheng Yuli Huang Non-alcoholic fatty liver disease is associated with increased risk of chronic kidney disease Therapeutic Advances in Chronic Disease |
| title | Non-alcoholic fatty liver disease is associated with increased risk of chronic kidney disease |
| title_full | Non-alcoholic fatty liver disease is associated with increased risk of chronic kidney disease |
| title_fullStr | Non-alcoholic fatty liver disease is associated with increased risk of chronic kidney disease |
| title_full_unstemmed | Non-alcoholic fatty liver disease is associated with increased risk of chronic kidney disease |
| title_short | Non-alcoholic fatty liver disease is associated with increased risk of chronic kidney disease |
| title_sort | non alcoholic fatty liver disease is associated with increased risk of chronic kidney disease |
| url | https://doi.org/10.1177/20406223211024361 |
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