Associations of cumulative average dietary total antioxidant capacity and intake of antioxidants with metabolic syndrome risk in Korean adults aged 40 years and older: a prospective cohort study (KoGES_CAVAS)
OBJECTIVES Limited and inconsistent prospective evidence exists regarding the relationship of dietary total antioxidant capacity (dTAC) and antioxidant intake with metabolic syndrome (MetS) risk. We evaluated the associations of the cumulative averages of dTAC and antioxidant intake (in 5 classes: r...
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| Format: | Article |
| Language: | English |
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Korean Society of Epidemiology
2023-07-01
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| Series: | Epidemiology and Health |
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| Online Access: | http://www.e-epih.org/upload/epih-45-e2023067.pdf |
| _version_ | 1797305321249570816 |
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| author | Ji-Sook Kong Jiseon Lee Youngjun Kim Hye Won Woo Min-Ho Shin Sang Baek Koh Hyeon Chang Kim Yu-Mi Kim Mi Kyung Kim |
| author_facet | Ji-Sook Kong Jiseon Lee Youngjun Kim Hye Won Woo Min-Ho Shin Sang Baek Koh Hyeon Chang Kim Yu-Mi Kim Mi Kyung Kim |
| author_sort | Ji-Sook Kong |
| collection | DOAJ |
| description | OBJECTIVES Limited and inconsistent prospective evidence exists regarding the relationship of dietary total antioxidant capacity (dTAC) and antioxidant intake with metabolic syndrome (MetS) risk. We evaluated the associations of the cumulative averages of dTAC and antioxidant intake (in 5 classes: retinol, vitamin C, vitamin E, carotenoids, and flavonoids, as well as 7 flavonoid subclasses) with the risk of MetS. METHODS This study included 11,379 participants without MetS, drawn from the Korean Genome and Epidemiology Study_CArdioVascular disease Association Study (KoGES_CAVAS). The cumulative average consumption was calculated using repeated food frequency questionnaires. Incidence rate ratios were estimated using a modified Poisson regression model with a robust error estimator. RESULTS The median follow-up period was 5.16 years, and 2,416 cases of MetS were recorded over 58,750 person-years. In men, significant inverse associations were observed in all 5 antioxidant classes, except for the highest quartile of dTAC. In women, dTAC and total flavonoids were not significantly associated with MetS; however, significant L-shaped associations were found for the remaining 4 antioxidant classes. Of the 7 flavonoid subclasses, only flavones in the highest quartile for men and flavan-3-ols in women lacked significant associations with MetS. The inverse associations were not sex-specific, but they were particularly pronounced among participants with a body mass index (BMI) of 23 kg/m2 or higher. CONCLUSIONS The findings suggest that most antioxidant classes and flavonoid subclasses, unlike dTAC, exhibit a clear beneficial association with MetS in an L-shaped pattern in both men and women, particularly those with a high BMI. |
| first_indexed | 2024-03-08T00:24:13Z |
| format | Article |
| id | doaj.art-ca63d2b44cdc4bd58fbfb7160048ce00 |
| institution | Directory Open Access Journal |
| issn | 2092-7193 |
| language | English |
| last_indexed | 2024-03-08T00:24:13Z |
| publishDate | 2023-07-01 |
| publisher | Korean Society of Epidemiology |
| record_format | Article |
| series | Epidemiology and Health |
| spelling | doaj.art-ca63d2b44cdc4bd58fbfb7160048ce002024-02-16T01:04:25ZengKorean Society of EpidemiologyEpidemiology and Health2092-71932023-07-014510.4178/epih.e20230671429Associations of cumulative average dietary total antioxidant capacity and intake of antioxidants with metabolic syndrome risk in Korean adults aged 40 years and older: a prospective cohort study (KoGES_CAVAS)Ji-Sook Kong0Jiseon Lee1Youngjun Kim2Hye Won Woo3Min-Ho Shin4Sang Baek Koh5Hyeon Chang Kim6Yu-Mi Kim7Mi Kyung Kim8 Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea Department of Preventive Medicine and Institute of Occupational Medicine, Yonsei Wonju College of Medicine, Wonju, Korea Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, KoreaOBJECTIVES Limited and inconsistent prospective evidence exists regarding the relationship of dietary total antioxidant capacity (dTAC) and antioxidant intake with metabolic syndrome (MetS) risk. We evaluated the associations of the cumulative averages of dTAC and antioxidant intake (in 5 classes: retinol, vitamin C, vitamin E, carotenoids, and flavonoids, as well as 7 flavonoid subclasses) with the risk of MetS. METHODS This study included 11,379 participants without MetS, drawn from the Korean Genome and Epidemiology Study_CArdioVascular disease Association Study (KoGES_CAVAS). The cumulative average consumption was calculated using repeated food frequency questionnaires. Incidence rate ratios were estimated using a modified Poisson regression model with a robust error estimator. RESULTS The median follow-up period was 5.16 years, and 2,416 cases of MetS were recorded over 58,750 person-years. In men, significant inverse associations were observed in all 5 antioxidant classes, except for the highest quartile of dTAC. In women, dTAC and total flavonoids were not significantly associated with MetS; however, significant L-shaped associations were found for the remaining 4 antioxidant classes. Of the 7 flavonoid subclasses, only flavones in the highest quartile for men and flavan-3-ols in women lacked significant associations with MetS. The inverse associations were not sex-specific, but they were particularly pronounced among participants with a body mass index (BMI) of 23 kg/m2 or higher. CONCLUSIONS The findings suggest that most antioxidant classes and flavonoid subclasses, unlike dTAC, exhibit a clear beneficial association with MetS in an L-shaped pattern in both men and women, particularly those with a high BMI.http://www.e-epih.org/upload/epih-45-e2023067.pdfantioxidantsflavonoidsvitaminsmetabolic syndromeobesitycohort study |
| spellingShingle | Ji-Sook Kong Jiseon Lee Youngjun Kim Hye Won Woo Min-Ho Shin Sang Baek Koh Hyeon Chang Kim Yu-Mi Kim Mi Kyung Kim Associations of cumulative average dietary total antioxidant capacity and intake of antioxidants with metabolic syndrome risk in Korean adults aged 40 years and older: a prospective cohort study (KoGES_CAVAS) Epidemiology and Health antioxidants flavonoids vitamins metabolic syndrome obesity cohort study |
| title | Associations of cumulative average dietary total antioxidant capacity and intake of antioxidants with metabolic syndrome risk in Korean adults aged 40 years and older: a prospective cohort study (KoGES_CAVAS) |
| title_full | Associations of cumulative average dietary total antioxidant capacity and intake of antioxidants with metabolic syndrome risk in Korean adults aged 40 years and older: a prospective cohort study (KoGES_CAVAS) |
| title_fullStr | Associations of cumulative average dietary total antioxidant capacity and intake of antioxidants with metabolic syndrome risk in Korean adults aged 40 years and older: a prospective cohort study (KoGES_CAVAS) |
| title_full_unstemmed | Associations of cumulative average dietary total antioxidant capacity and intake of antioxidants with metabolic syndrome risk in Korean adults aged 40 years and older: a prospective cohort study (KoGES_CAVAS) |
| title_short | Associations of cumulative average dietary total antioxidant capacity and intake of antioxidants with metabolic syndrome risk in Korean adults aged 40 years and older: a prospective cohort study (KoGES_CAVAS) |
| title_sort | associations of cumulative average dietary total antioxidant capacity and intake of antioxidants with metabolic syndrome risk in korean adults aged 40 years and older a prospective cohort study koges cavas |
| topic | antioxidants flavonoids vitamins metabolic syndrome obesity cohort study |
| url | http://www.e-epih.org/upload/epih-45-e2023067.pdf |
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