Maintenance Therapy for Children and Adolescents with Asthma: Guidelines and Recommendations from the Emilia-Romagna Asthma (ERA) Study Group
Asthma is the most frequent chronic disease of childhood, affecting up to 20% of children worldwide. The main guidelines on asthma maintenance therapy in pediatrics suggest different approaches and describe different stages of asthma to determine the most appropriate treatment. This project aims to...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/17/5467 |
| _version_ | 1797582351842148352 |
|---|---|
| author | Valentina Fainardi Carlo Caffarelli Michela Deolmi Giulia Zambelli Elisabetta Palazzolo Sara Scavone Barbara Maria Bergamini Luca Bertelli Loretta Biserna Paolo Bottau Elena Corinaldesi Nicoletta De Paulis Emanuela Di Palmo Arianna Dondi Marcella Gallucci Battista Guidi Francesca Lombardi Maria Sole Magistrali Elisabetta Marastoni Silvia Pastorelli Alessandra Piccorossi Maurizio Poloni Sylvie Tagliati Francesca Vaienti Giuseppe Gregori Roberto Sacchetti Francesco Antodaro Andrea Bergomi Lamberto Reggiani Alessandro De Fanti Federico Marchetti Roberto Grandinetti Nicole Mussi Giampaolo Ricci Susanna Esposito |
| author_facet | Valentina Fainardi Carlo Caffarelli Michela Deolmi Giulia Zambelli Elisabetta Palazzolo Sara Scavone Barbara Maria Bergamini Luca Bertelli Loretta Biserna Paolo Bottau Elena Corinaldesi Nicoletta De Paulis Emanuela Di Palmo Arianna Dondi Marcella Gallucci Battista Guidi Francesca Lombardi Maria Sole Magistrali Elisabetta Marastoni Silvia Pastorelli Alessandra Piccorossi Maurizio Poloni Sylvie Tagliati Francesca Vaienti Giuseppe Gregori Roberto Sacchetti Francesco Antodaro Andrea Bergomi Lamberto Reggiani Alessandro De Fanti Federico Marchetti Roberto Grandinetti Nicole Mussi Giampaolo Ricci Susanna Esposito |
| author_sort | Valentina Fainardi |
| collection | DOAJ |
| description | Asthma is the most frequent chronic disease of childhood, affecting up to 20% of children worldwide. The main guidelines on asthma maintenance therapy in pediatrics suggest different approaches and describe different stages of asthma to determine the most appropriate treatment. This project aims to summarize the most recent evidence regarding maintenance therapy for asthma in children and adolescents. A multidisciplinary panel of experts was asked clinical questions regarding the treatment of children and adolescents with asthma. Overall, 10 clinical questions were addressed, and the search strategy included accessing electronic databases and a manual search of gray literature published in the last 25 years. After data extraction and narrative synthesis of results, recommendations were developed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) methodology. Results showed that the choice of medication depends on the severity of the child’s asthma, phenotype, age, preference, and individual factors. In addition to medications, the identification of comorbidities and modifiable factors is crucial to obtaining good control. Asthma in children is heterogeneous, and its evolution varies over time. Since most recommendations for asthma management in childhood are extrapolated from clinical studies performed in adults, more clinical trials specifically designed for young children should be conducted. |
| first_indexed | 2024-03-10T23:20:53Z |
| format | Article |
| id | doaj.art-ca65e15222ce48a4b83ef1fb81d839e1 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T23:20:53Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ca65e15222ce48a4b83ef1fb81d839e12023-11-19T08:21:03ZengMDPI AGJournal of Clinical Medicine2077-03832023-08-011217546710.3390/jcm12175467Maintenance Therapy for Children and Adolescents with Asthma: Guidelines and Recommendations from the Emilia-Romagna Asthma (ERA) Study GroupValentina Fainardi0Carlo Caffarelli1Michela Deolmi2Giulia Zambelli3Elisabetta Palazzolo4Sara Scavone5Barbara Maria Bergamini6Luca Bertelli7Loretta Biserna8Paolo Bottau9Elena Corinaldesi10Nicoletta De Paulis11Emanuela Di Palmo12Arianna Dondi13Marcella Gallucci14Battista Guidi15Francesca Lombardi16Maria Sole Magistrali17Elisabetta Marastoni18Silvia Pastorelli19Alessandra Piccorossi20Maurizio Poloni21Sylvie Tagliati22Francesca Vaienti23Giuseppe Gregori24Roberto Sacchetti25Francesco Antodaro26Andrea Bergomi27Lamberto Reggiani28Alessandro De Fanti29Federico Marchetti30Roberto Grandinetti31Nicole Mussi32Giampaolo Ricci33Susanna Esposito34Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyPediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyPediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyPediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyPediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyPediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyPaediatric Unit, Department of Medical and Surgical Sciences of Mothers, Children and Adults, University of Modena and Reggio Emilia, 41125 Modena, ItalyPediatric Clinic, Scientific Institute for Research and Healthcare (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyPaediatrics and Neonatology Unit, Ravenna Hospital, Azienda Unità Sanitaria Locale (AUSL) Romagna, 48121 Ravenna, ItalyPaediatrics Unit, Imola Hospital, 40026 Imola, ItalyPaediatric Unit, Carpi Hospital, 41012 Carpi, ItalyPaediatrics and Neonatology Unit, Guglielmo da Saliceto Hospital, 29121 Piacenza, ItalyPediatric Clinic, Scientific Institute for Research and Healthcare (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyPediatric Clinic, Scientific Institute for Research and Healthcare (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyPediatric Clinic, Scientific Institute for Research and Healthcare (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyHospital and Territorial Paediatrics Unit, 41026 Pavullo, ItalyPaediatrics Unit, Maggiore Hospital, 40133 Bologna, ItalyPaediatrics and Neonatology Unit, Guglielmo da Saliceto Hospital, 29121 Piacenza, ItalyPaediatrics Unit, Santa Maria Nuova Hospital, Azienda Unità Sanitaria Locale (AUSL)-Scientific Institute for Research and Healthcare (IRCCS) of Reggio Emilia, 42123 Reggio Emilia, ItalyPaediatrics Unit, Sassuolo Hospital, 41049 Sassuolo, ItalyPaediatrics and Paediatric Intensive Care Unit, Cesena Hospital, Azienda Unità Sanitaria Locale (AUSL) Romagna, 47521 Cesena, ItalyPaediatrics Unit, Rimini Hospital, Azienda Unità Sanitaria Locale (AUSL) Romagna, 47921 Rimini, ItalyPaediatric Clinic, Ferrara Hospital, 44124 Ferrara, ItalyPaediatrics Unit, G.B. Morgagni Pierantoni Hospital, Azienda Unità Sanitaria Locale (AUSL) Romagna, 47121 Forlì, ItalyPrimary Care Pediatricians, Azienda Unità Sanitaria Locale (AUSL) Piacenza, 29121 Piacenza, ItalyPrimary Care Pediatricians, Azienda Unità Sanitaria Locale (AUSL) Piacenza, 29121 Piacenza, ItalyPrimary Care Pediatricians, Azienda Unità Sanitaria Locale (AUSL) Modena, 41125 Modena, ItalyPrimary Care Pediatricians, Azienda Unità Sanitaria Locale (AUSL) Modena, 41125 Modena, ItalyPrimary Care Pediatricians, Azienda Unità Sanitaria Locale (AUSL) Imola, 40026 Imola, ItalyPaediatrics Unit, Santa Maria Nuova Hospital, Azienda Unità Sanitaria Locale (AUSL)-Scientific Institute for Research and Healthcare (IRCCS) of Reggio Emilia, 42123 Reggio Emilia, ItalyPaediatrics and Neonatology Unit, Ravenna Hospital, Azienda Unità Sanitaria Locale (AUSL) Romagna, 48121 Ravenna, ItalyPediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyPediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyPediatric Clinic, Scientific Institute for Research and Healthcare (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyPediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyAsthma is the most frequent chronic disease of childhood, affecting up to 20% of children worldwide. The main guidelines on asthma maintenance therapy in pediatrics suggest different approaches and describe different stages of asthma to determine the most appropriate treatment. This project aims to summarize the most recent evidence regarding maintenance therapy for asthma in children and adolescents. A multidisciplinary panel of experts was asked clinical questions regarding the treatment of children and adolescents with asthma. Overall, 10 clinical questions were addressed, and the search strategy included accessing electronic databases and a manual search of gray literature published in the last 25 years. After data extraction and narrative synthesis of results, recommendations were developed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) methodology. Results showed that the choice of medication depends on the severity of the child’s asthma, phenotype, age, preference, and individual factors. In addition to medications, the identification of comorbidities and modifiable factors is crucial to obtaining good control. Asthma in children is heterogeneous, and its evolution varies over time. Since most recommendations for asthma management in childhood are extrapolated from clinical studies performed in adults, more clinical trials specifically designed for young children should be conducted.https://www.mdpi.com/2077-0383/12/17/5467asthmainhaled corticosteroidlong-acting beta agonistoral corticosteroidspediatric pulmonologyshort-acting beta agonist |
| spellingShingle | Valentina Fainardi Carlo Caffarelli Michela Deolmi Giulia Zambelli Elisabetta Palazzolo Sara Scavone Barbara Maria Bergamini Luca Bertelli Loretta Biserna Paolo Bottau Elena Corinaldesi Nicoletta De Paulis Emanuela Di Palmo Arianna Dondi Marcella Gallucci Battista Guidi Francesca Lombardi Maria Sole Magistrali Elisabetta Marastoni Silvia Pastorelli Alessandra Piccorossi Maurizio Poloni Sylvie Tagliati Francesca Vaienti Giuseppe Gregori Roberto Sacchetti Francesco Antodaro Andrea Bergomi Lamberto Reggiani Alessandro De Fanti Federico Marchetti Roberto Grandinetti Nicole Mussi Giampaolo Ricci Susanna Esposito Maintenance Therapy for Children and Adolescents with Asthma: Guidelines and Recommendations from the Emilia-Romagna Asthma (ERA) Study Group Journal of Clinical Medicine asthma inhaled corticosteroid long-acting beta agonist oral corticosteroids pediatric pulmonology short-acting beta agonist |
| title | Maintenance Therapy for Children and Adolescents with Asthma: Guidelines and Recommendations from the Emilia-Romagna Asthma (ERA) Study Group |
| title_full | Maintenance Therapy for Children and Adolescents with Asthma: Guidelines and Recommendations from the Emilia-Romagna Asthma (ERA) Study Group |
| title_fullStr | Maintenance Therapy for Children and Adolescents with Asthma: Guidelines and Recommendations from the Emilia-Romagna Asthma (ERA) Study Group |
| title_full_unstemmed | Maintenance Therapy for Children and Adolescents with Asthma: Guidelines and Recommendations from the Emilia-Romagna Asthma (ERA) Study Group |
| title_short | Maintenance Therapy for Children and Adolescents with Asthma: Guidelines and Recommendations from the Emilia-Romagna Asthma (ERA) Study Group |
| title_sort | maintenance therapy for children and adolescents with asthma guidelines and recommendations from the emilia romagna asthma era study group |
| topic | asthma inhaled corticosteroid long-acting beta agonist oral corticosteroids pediatric pulmonology short-acting beta agonist |
| url | https://www.mdpi.com/2077-0383/12/17/5467 |
| work_keys_str_mv | AT valentinafainardi maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT carlocaffarelli maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT micheladeolmi maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT giuliazambelli maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT elisabettapalazzolo maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT sarascavone maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT barbaramariabergamini maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT lucabertelli maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT lorettabiserna maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT paolobottau maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT elenacorinaldesi maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT nicolettadepaulis maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT emanueladipalmo maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT ariannadondi maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT marcellagallucci maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT battistaguidi maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT francescalombardi maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT mariasolemagistrali maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT elisabettamarastoni maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT silviapastorelli maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT alessandrapiccorossi maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT mauriziopoloni maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT sylvietagliati maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT francescavaienti maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT giuseppegregori maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT robertosacchetti maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT francescoantodaro maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT andreabergomi maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT lambertoreggiani maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT alessandrodefanti maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT federicomarchetti maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT robertograndinetti maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT nicolemussi maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT giampaoloricci maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup AT susannaesposito maintenancetherapyforchildrenandadolescentswithasthmaguidelinesandrecommendationsfromtheemiliaromagnaasthmaerastudygroup |