Structural Insight into Non-Enveloped Virus Binding to Glycosaminoglycan Receptors: A Review
Viruses are infectious agents that hijack the host cell machinery in order to replicate and generate progeny. Viral infection is initiated by attachment to host cell receptors, and typical viral receptors are cell-surface-borne molecules such as proteins or glycan structures. Sialylated glycans (gly...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/5/800 |
| _version_ | 1797535805786292224 |
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| author | Marie N. Sorin Jasmin Kuhn Aleksandra C. Stasiak Thilo Stehle |
| author_facet | Marie N. Sorin Jasmin Kuhn Aleksandra C. Stasiak Thilo Stehle |
| author_sort | Marie N. Sorin |
| collection | DOAJ |
| description | Viruses are infectious agents that hijack the host cell machinery in order to replicate and generate progeny. Viral infection is initiated by attachment to host cell receptors, and typical viral receptors are cell-surface-borne molecules such as proteins or glycan structures. Sialylated glycans (glycans bearing sialic acids) and glycosaminoglycans (GAGs) represent major classes of carbohydrate receptors and have been implicated in facilitating viral entry for many viruses. As interactions between viruses and sialic acids have been extensively reviewed in the past, this review provides an overview of the current state of structural knowledge about interactions between non-enveloped human viruses and GAGs. We focus here on adeno-associated viruses, human papilloma viruses (HPVs), and polyomaviruses, as at least some structural information about the interactions of these viruses with GAGs is available. We also discuss the multivalent potential for GAG binding, highlighting the importance of charged interactions and positively charged amino acids at the binding sites, and point out challenges that remain in the field. |
| first_indexed | 2024-03-10T11:50:32Z |
| format | Article |
| id | doaj.art-ca696cdef5c2437f9fda93b54756f92a |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T11:50:32Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-ca696cdef5c2437f9fda93b54756f92a2023-11-21T17:47:57ZengMDPI AGViruses1999-49152021-04-0113580010.3390/v13050800Structural Insight into Non-Enveloped Virus Binding to Glycosaminoglycan Receptors: A ReviewMarie N. Sorin0Jasmin Kuhn1Aleksandra C. Stasiak2Thilo Stehle3Interfaculty Institute of Biochemistry, University of Tuebingen, 72076 Tuebingen, GermanyInterfaculty Institute of Biochemistry, University of Tuebingen, 72076 Tuebingen, GermanyInterfaculty Institute of Biochemistry, University of Tuebingen, 72076 Tuebingen, GermanyInterfaculty Institute of Biochemistry, University of Tuebingen, 72076 Tuebingen, GermanyViruses are infectious agents that hijack the host cell machinery in order to replicate and generate progeny. Viral infection is initiated by attachment to host cell receptors, and typical viral receptors are cell-surface-borne molecules such as proteins or glycan structures. Sialylated glycans (glycans bearing sialic acids) and glycosaminoglycans (GAGs) represent major classes of carbohydrate receptors and have been implicated in facilitating viral entry for many viruses. As interactions between viruses and sialic acids have been extensively reviewed in the past, this review provides an overview of the current state of structural knowledge about interactions between non-enveloped human viruses and GAGs. We focus here on adeno-associated viruses, human papilloma viruses (HPVs), and polyomaviruses, as at least some structural information about the interactions of these viruses with GAGs is available. We also discuss the multivalent potential for GAG binding, highlighting the importance of charged interactions and positively charged amino acids at the binding sites, and point out challenges that remain in the field.https://www.mdpi.com/1999-4915/13/5/800virusesglycansglycosaminoglycansglycovirologynon-enveloped virusesstructural biology |
| spellingShingle | Marie N. Sorin Jasmin Kuhn Aleksandra C. Stasiak Thilo Stehle Structural Insight into Non-Enveloped Virus Binding to Glycosaminoglycan Receptors: A Review Viruses viruses glycans glycosaminoglycans glycovirology non-enveloped viruses structural biology |
| title | Structural Insight into Non-Enveloped Virus Binding to Glycosaminoglycan Receptors: A Review |
| title_full | Structural Insight into Non-Enveloped Virus Binding to Glycosaminoglycan Receptors: A Review |
| title_fullStr | Structural Insight into Non-Enveloped Virus Binding to Glycosaminoglycan Receptors: A Review |
| title_full_unstemmed | Structural Insight into Non-Enveloped Virus Binding to Glycosaminoglycan Receptors: A Review |
| title_short | Structural Insight into Non-Enveloped Virus Binding to Glycosaminoglycan Receptors: A Review |
| title_sort | structural insight into non enveloped virus binding to glycosaminoglycan receptors a review |
| topic | viruses glycans glycosaminoglycans glycovirology non-enveloped viruses structural biology |
| url | https://www.mdpi.com/1999-4915/13/5/800 |
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