Serum lipid biomarkers and inflammatory cytokines associated with onset and clinical status of patients with early knee osteoarthritis
IntroductionOsteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. The role of serum lipid and inflammatory biomarkers in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1126796/full |
| _version_ | 1797870615486529536 |
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| author | Luz Herrero-Manley Ana Alabajos-Cea Ana Alabajos-Cea Luis Suso-Martí Ferran Cuenca-Martínez Joaquín Calatayud José Casaña Enrique Viosca-Herrero Isabel Vázquez-Arce Francisco José Ferrer-Sargues María Blanco-Díaz |
| author_facet | Luz Herrero-Manley Ana Alabajos-Cea Ana Alabajos-Cea Luis Suso-Martí Ferran Cuenca-Martínez Joaquín Calatayud José Casaña Enrique Viosca-Herrero Isabel Vázquez-Arce Francisco José Ferrer-Sargues María Blanco-Díaz |
| author_sort | Luz Herrero-Manley |
| collection | DOAJ |
| description | IntroductionOsteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. The role of serum lipid and inflammatory biomarkers in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment. The primary aim of this study was to evaluate differences of serum lipid and inflammatory biomarkers with knee EOA in comparison with matched controls, in order to determine the role of these factors in the origin of EOA.MethodsFor this proposal, a cross-sectional study with a non-randomized sample was performed. 48 subjects with early osteoarthritis (EOA) and 48 matched controls were selected and serum lipid levels (total cholesterol, LDL, HDL) and inflammatory biomarkers C-reactive protein (CRP), uric acid (UA) were analyzed. In addition, clinical (pain, disability) and functional (gait speed, sit-to-stand) variables were measured to establish their relationship to serum lipid levels and inflammatory biomarkers.ResultsPatients with EOA showed higher levels of total cholesterol LDL, UA, and CRP. Higher levels of total cholesterol, LDL and CRP were correlated with higher levels of pain intensity and higher disability (p < 0.05). In addition, UA and CRP were inversely correlated with gait speed and sit-to-stand tests (r = −0.038 to −0.5, p < 0.05).ConclusionThese results highlight the relevance of metabolic and proinflammatory aspects in the early stages of knee OA and could be key to developing early diagnoses to prevent the onset and development of the disease. |
| first_indexed | 2024-04-10T00:31:18Z |
| format | Article |
| id | doaj.art-ca699fdb182b4048abe0a5b320e00a26 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T00:31:18Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-ca699fdb182b4048abe0a5b320e00a262023-03-15T04:25:21ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-03-011010.3389/fnut.2023.11267961126796Serum lipid biomarkers and inflammatory cytokines associated with onset and clinical status of patients with early knee osteoarthritisLuz Herrero-Manley0Ana Alabajos-Cea1Ana Alabajos-Cea2Luis Suso-Martí3Ferran Cuenca-Martínez4Joaquín Calatayud5José Casaña6Enrique Viosca-Herrero7Isabel Vázquez-Arce8Francisco José Ferrer-Sargues9María Blanco-Díaz10Servicio de Medicina Física y Rehabilitación, Hospital La Fe, Valencia, SpainServicio de Medicina Física y Rehabilitación, Hospital La Fe, Valencia, SpainGrupo de Investigación en Medicina Física y Rehabilitación, Instituto de Investigación Sanitaria La Fe (IISLAFE), Valencia, SpainExercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, Valencia, SpainDepartment of Physiotherapy, University of Valencia, Valencia, SpainExercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, Valencia, SpainExercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, Valencia, SpainServicio de Medicina Física y Rehabilitación, Hospital La Fe, Valencia, SpainServicio de Medicina Física y Rehabilitación, Hospital La Fe, Valencia, SpainDepartment of Physiotherapy, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, SpainDepartment of Surgery and Medical Surgical Specialties, Faculty of Medicine and Health Sciences, University of Oviedo, Oviedo, SpainIntroductionOsteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. The role of serum lipid and inflammatory biomarkers in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment. The primary aim of this study was to evaluate differences of serum lipid and inflammatory biomarkers with knee EOA in comparison with matched controls, in order to determine the role of these factors in the origin of EOA.MethodsFor this proposal, a cross-sectional study with a non-randomized sample was performed. 48 subjects with early osteoarthritis (EOA) and 48 matched controls were selected and serum lipid levels (total cholesterol, LDL, HDL) and inflammatory biomarkers C-reactive protein (CRP), uric acid (UA) were analyzed. In addition, clinical (pain, disability) and functional (gait speed, sit-to-stand) variables were measured to establish their relationship to serum lipid levels and inflammatory biomarkers.ResultsPatients with EOA showed higher levels of total cholesterol LDL, UA, and CRP. Higher levels of total cholesterol, LDL and CRP were correlated with higher levels of pain intensity and higher disability (p < 0.05). In addition, UA and CRP were inversely correlated with gait speed and sit-to-stand tests (r = −0.038 to −0.5, p < 0.05).ConclusionThese results highlight the relevance of metabolic and proinflammatory aspects in the early stages of knee OA and could be key to developing early diagnoses to prevent the onset and development of the disease.https://www.frontiersin.org/articles/10.3389/fnut.2023.1126796/fullosteoarthritisearly osteoarthritisserum lipidinflammatory biomarkerscytokine |
| spellingShingle | Luz Herrero-Manley Ana Alabajos-Cea Ana Alabajos-Cea Luis Suso-Martí Ferran Cuenca-Martínez Joaquín Calatayud José Casaña Enrique Viosca-Herrero Isabel Vázquez-Arce Francisco José Ferrer-Sargues María Blanco-Díaz Serum lipid biomarkers and inflammatory cytokines associated with onset and clinical status of patients with early knee osteoarthritis Frontiers in Nutrition osteoarthritis early osteoarthritis serum lipid inflammatory biomarkers cytokine |
| title | Serum lipid biomarkers and inflammatory cytokines associated with onset and clinical status of patients with early knee osteoarthritis |
| title_full | Serum lipid biomarkers and inflammatory cytokines associated with onset and clinical status of patients with early knee osteoarthritis |
| title_fullStr | Serum lipid biomarkers and inflammatory cytokines associated with onset and clinical status of patients with early knee osteoarthritis |
| title_full_unstemmed | Serum lipid biomarkers and inflammatory cytokines associated with onset and clinical status of patients with early knee osteoarthritis |
| title_short | Serum lipid biomarkers and inflammatory cytokines associated with onset and clinical status of patients with early knee osteoarthritis |
| title_sort | serum lipid biomarkers and inflammatory cytokines associated with onset and clinical status of patients with early knee osteoarthritis |
| topic | osteoarthritis early osteoarthritis serum lipid inflammatory biomarkers cytokine |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1126796/full |
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