Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions
Heterocycles are ubiquitous in bioactive compounds and routes to different substitution patterns are important to access the full substrate space. Here the authors report a route to 4,5,7,8-substituted antiviral fluorescent quinazolines, to allow cellular uptake visualization without external marker...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15071 |
| _version_ | 1818345377321975808 |
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| author | Felix E. Held Anton A. Guryev Tony Fröhlich Frank Hampel Axel Kahnt Corina Hutterer Mirjam Steingruber Hanife Bahsi Clemens von Bojničić-Kninski Daniela S. Mattes Tobias C. Foertsch Alexander Nesterov-Mueller Manfred Marschall Svetlana B. Tsogoeva |
| author_facet | Felix E. Held Anton A. Guryev Tony Fröhlich Frank Hampel Axel Kahnt Corina Hutterer Mirjam Steingruber Hanife Bahsi Clemens von Bojničić-Kninski Daniela S. Mattes Tobias C. Foertsch Alexander Nesterov-Mueller Manfred Marschall Svetlana B. Tsogoeva |
| author_sort | Felix E. Held |
| collection | DOAJ |
| description | Heterocycles are ubiquitous in bioactive compounds and routes to different substitution patterns are important to access the full substrate space. Here the authors report a route to 4,5,7,8-substituted antiviral fluorescent quinazolines, to allow cellular uptake visualization without external marker. |
| first_indexed | 2024-12-13T17:01:24Z |
| format | Article |
| id | doaj.art-ca6b3826d1e94ad6b59eb0bddea12063 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T17:01:24Z |
| publishDate | 2017-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ca6b3826d1e94ad6b59eb0bddea120632022-12-21T23:37:48ZengNature PortfolioNature Communications2041-17232017-05-01811910.1038/ncomms15071Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactionsFelix E. Held0Anton A. Guryev1Tony Fröhlich2Frank Hampel3Axel Kahnt4Corina Hutterer5Mirjam Steingruber6Hanife Bahsi7Clemens von Bojničić-Kninski8Daniela S. Mattes9Tobias C. Foertsch10Alexander Nesterov-Mueller11Manfred Marschall12Svetlana B. Tsogoeva13Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials, Friedrich-Alexander University of Erlangen-NürnbergOrganic Chemistry Chair I and Interdisciplinary Center for Molecular Materials, Friedrich-Alexander University of Erlangen-NürnbergOrganic Chemistry Chair I and Interdisciplinary Center for Molecular Materials, Friedrich-Alexander University of Erlangen-NürnbergOrganic Chemistry Chair I and Interdisciplinary Center for Molecular Materials, Friedrich-Alexander University of Erlangen-NürnbergPhysical Chemistry Chair I, Friedrich-Alexander University of Erlangen-NürnbergInstitute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-NürnbergInstitute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-NürnbergInstitute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-NürnbergKarlsruhe Institute of Technology, Institute of Microstructure TechnologyKarlsruhe Institute of Technology, Institute of Microstructure TechnologyKarlsruhe Institute of Technology, Institute of Microstructure TechnologyKarlsruhe Institute of Technology, Institute of Microstructure TechnologyInstitute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-NürnbergOrganic Chemistry Chair I and Interdisciplinary Center for Molecular Materials, Friedrich-Alexander University of Erlangen-NürnbergHeterocycles are ubiquitous in bioactive compounds and routes to different substitution patterns are important to access the full substrate space. Here the authors report a route to 4,5,7,8-substituted antiviral fluorescent quinazolines, to allow cellular uptake visualization without external marker.https://doi.org/10.1038/ncomms15071 |
| spellingShingle | Felix E. Held Anton A. Guryev Tony Fröhlich Frank Hampel Axel Kahnt Corina Hutterer Mirjam Steingruber Hanife Bahsi Clemens von Bojničić-Kninski Daniela S. Mattes Tobias C. Foertsch Alexander Nesterov-Mueller Manfred Marschall Svetlana B. Tsogoeva Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions Nature Communications |
| title | Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions |
| title_full | Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions |
| title_fullStr | Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions |
| title_full_unstemmed | Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions |
| title_short | Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions |
| title_sort | facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal free domino reactions |
| url | https://doi.org/10.1038/ncomms15071 |
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